INT117622

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 4.84
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B1) protein folding (HSP90B1) cytosol (HSP90B1)
endoplasmic reticulum (HSP90B1) RNA binding (HSP90B1) response to stress (HSP90B1)
Anatomy Link Frequency
ileum 1
reticulum 1
HSP90B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 204 100.00 Very High Very High Very High
Inflammation 29 99.42 Very High Very High Very High
tolerance 2 79.56 Quite High
chemokine 9 78.84 Quite High
Paracetamol 1 75.20 Quite High
Nerve growth factor 1 55.52 Quite High
Central nervous system 21 53.80 Quite High
rheumatoid arthritis 4 51.44 Quite High
Multiple sclerosis 1 36.96 Quite Low
abdominal pain 4 17.28 Low Low
Disease Link Frequency Relevance Heat
Disease 229 100.00 Very High Very High Very High
Stress 79 100.00 Very High Very High Very High
INFLAMMATION 28 99.42 Very High Very High Very High
Lymphatic System Cancer 4 97.36 Very High Very High Very High
Inflammatory Bowel Disease 48 92.56 High High
Sprains And Strains 109 91.40 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 89.80 High High
Targeted Disruption 10 89.40 High High
Toxicity 1 84.92 Quite High
Adhesions 27 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of the endoplasmic reticulum stress proteins GRP78, GRP94, calreticulin and protein disulfide isomerase was assessed by immunoblotting.
Positive_regulation (Induction) of GRP94 in reticulum associated with stress
1) Confidence 0.43 Published 2004 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 15049342 Disease Relevance 0.59 Pain Relevance 0.11
The Gp96 expression level in the ileum from patients in the quiescent phase of CD was still increased compared with that in the ileum from controls.
Positive_regulation (increased) of Gp96 in ileum associated with crohn's disease
2) Confidence 0.30 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.70 Pain Relevance 0.35
specific to the gp96 mRNA and 5?
Positive_regulation (specific) of gp96
3) Confidence 0.21 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.46 Pain Relevance 0.03
The ability of LF82 OMVs to promote invasion involves OmpA and Gp96
Positive_regulation (involves) of Gp96
4) Confidence 0.21 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.52 Pain Relevance 0
The increased expression of the ER stress response chaperone Gp96 in CD could be either a primary cause or a consequence of intestinal inflammation, since it was reported that Gp96 is transcriptionally upregulated in IFN?
Positive_regulation (upregulated) of Gp96 associated with stress, inflammation and crohn's disease
5) Confidence 0.20 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 1.93 Pain Relevance 0.34
In a separate investigation by the same group, HIVgp120 was observed to trigger in HBMEC the activation of signal transducer and activator of transcription (STAT)-1 and the release of interleukin (IL)-6 and IL-8 [111].
Positive_regulation (activation) of HBMEC
6) Confidence 0.01 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 0.64 Pain Relevance 0.18

General Comments

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