INT117632

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 99
Total Number 102
Disease Relevance 29.41
Pain Relevance 30.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 31
DRG 11
sensory neurons 6
nerve 5
Internal 4
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 333 100.00 Very High Very High Very High
nociceptor 84 100.00 Very High Very High Very High
dorsal root ganglion 337 99.96 Very High Very High Very High
c fibre 76 99.82 Very High Very High Very High
Hippocampus 40 99.56 Very High Very High Very High
Calcitonin gene-related peptide 36 99.44 Very High Very High Very High
Cold hyperalgesia 22 99.40 Very High Very High Very High
Lasting pain 13 99.32 Very High Very High Very High
trigeminal ganglion 60 99.08 Very High Very High Very High
Inflammation 119 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 890 99.96 Very High Very High Very High
Nociception 342 99.80 Very High Very High Very High
Hyperalgesia 45 99.40 Very High Very High Very High
Overactive Bladder 68 99.36 Very High Very High Very High
Pain 313 99.32 Very High Very High Very High
Bladder Disease 80 99.32 Very High Very High Very High
Disease 25 99.32 Very High Very High Very High
INFLAMMATION 122 99.04 Very High Very High Very High
Nervous System Injury 27 98.92 Very High Very High Very High
Asthma 200 98.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPM8 expression was increased in a subset of sensory neurons after nerve injury.
Gene_expression (expression) of TRPM8 in nerve
1) Confidence 0.78 Published 2006 Journal Curr. Biol. Section Body Doc Link 16920620 Disease Relevance 0.08 Pain Relevance 0
By retrograde labeling afferent neurons that target hindlimb skin, we showed that the skin neurons expressed TRPM8 receptors, that the percentage of menthol-sensitive/cold-sensitive/capsaicin-sensitive neurons increased, and that the menthol- and cold-evoked responses were significantly enhanced in capsaicin-sensitive neurons after CCI.
Gene_expression (expressed) of TRPM8 in neurons associated with nervous system injury and qutenza
2) Confidence 0.78 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077679 Disease Relevance 0.95 Pain Relevance 0.68
Chemical and cold sensitivity of two distinct populations of TRPM8-expressing somatosensory neurons.
Gene_expression (expressing) of TRPM8 in neurons associated with qutenza
3) Confidence 0.78 Published 2006 Journal J. Neurophysiol. Section Title Doc Link 16424459 Disease Relevance 0.44 Pain Relevance 0.75
Using acutely dissociated rat dorsal root ganglion (DRG) neurons without culture, we show that TRPM8 receptors are expressed on two distinct classes of somatosensory neurons.
Gene_expression (expressed) of TRPM8 in DRG associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.78 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16424459 Disease Relevance 0.35 Pain Relevance 0.40
TRPM8 current density shows significant higher in MS/CIS neurons than in MS/CS neurons, suggesting different expression levels of TRPM8 receptors between the two neuron populations, and this difference may provide a mean of selective activation of MS/CIS neurons at low stimulation intensity.
Gene_expression (expression) of TRPM8 in neurons
5) Confidence 0.78 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16424459 Disease Relevance 0.22 Pain Relevance 0.35
We observed a high degree of functional co-expression of TRPM8, the receptors for the inflammatory agents bradykinin, prostaglandin E2 and histamine, and TRPA1 in cultured sensory neurones.
Gene_expression (co-expression) of TRPM8 associated with inflammation and bradykinin
6) Confidence 0.77 Published 2007 Journal Exp Brain Res Section Abstract Doc Link 17006682 Disease Relevance 0.58 Pain Relevance 0.38
It may also be interesting to examine species that experience substantial variations (short- or long-term) in environmental temperature, as there may be corresponding changes in TRPM8 expression and/or function that allow for optimal temperature detection under such circumstances.
Gene_expression (expression) of TRPM8
7) Confidence 0.77 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2683941 Disease Relevance 0 Pain Relevance 0.04
Single cell reverse transcription-PCR and immunohistochemistry revealed expression of TRPV1, TRPM8, and TRPA1 in subsets of such neurons.
Gene_expression (expression) of TRPM8 in neurons
8) Confidence 0.77 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16595689 Disease Relevance 0.16 Pain Relevance 0.52
In the earlier studies, TRPM8 receptors were reported to be only expressed on a subpopulation of dorsal root ganglion and trigeminal ganglion neurons in normal animals [12,13].
Gene_expression (expressed) of TRPM8 in neurons associated with ganglion cysts, dorsal root ganglion and trigeminal ganglion neurons
9) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 0.31 Pain Relevance 0.14
If TRPM8 is involved in cold-induced asthma and asthma exacerbation, it would be interesting to know whether TRPM8 receptor expression is up-regulated in those people who are susceptible to asthma such that they are more sensitive to cold than normal subjects.
Spec (whether) Gene_expression (expression) of TRPM8 receptor associated with asthma
10) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 1.18 Pain Relevance 0.04
The presence of TRPM8 receptors on neurons whose peripheral nerve endings innervate bronchopulmonary tissues predicts the expression of TRPM8 receptors on these nerve endings.
Gene_expression (expression) of TRPM8 in nerve
11) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 0.22 Pain Relevance 0.12
It is possible that TRPM8 receptors are mainly expressed on upper airway trees where these receptors serve as a sensor of cold temperatures to mediate reflexive responses.
Gene_expression (expressed) of TRPM8 in upper
12) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 0.67 Pain Relevance 0.05
The expression of TRPM8 receptors on autonomic afferent nerves innervating bronchopulmonary system has not been reported previously.
Gene_expression (expression) of TRPM8 in autonomic
13) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 0.31 Pain Relevance 0.13
We next determined whether TRPM8 proteins were expressed on VG neurons by immunostaining sections of ganglions using a TRPM8 antibody.
Gene_expression (expressed) of TRPM8 in neurons associated with ganglion cysts
14) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 0.70 Pain Relevance 0.08
Thus, TRPM8 receptors may be widely expressed on afferent fibers innervating visceral organs and to be involved in reflexive responses.
Gene_expression (expressed) of TRPM8 in visceral organs
15) Confidence 0.76 Published 2008 Journal Mol Pain Section Body Doc Link PMC2430548 Disease Relevance 0.26 Pain Relevance 0.08
Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors.
Gene_expression (expression) of TRPM8 in afferent neurons associated with c fibre and adelta
16) Confidence 0.75 Published 2005 Journal J. Comp. Neurol. Section Title Doc Link 16304633 Disease Relevance 0.41 Pain Relevance 0.51
Both A-fiber and C-fiber neurons expressed TRPM8, whereas TRPV1 was almost exclusively seen in C-fiber neurons.
Gene_expression (expressed) of TRPM8 in neurons associated with c fibre
17) Confidence 0.75 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16304633 Disease Relevance 0.61 Pain Relevance 0.66
Our data suggest heterogeneity of TRPM8 and TRPA1 expression by subpopulations of primary afferent neurons, which may result in the difference of cold-sensitive primary afferent neurons in sensitivity to chemicals such as menthol and capsaicin and nerve growth factor.
Gene_expression (expression) of TRPM8 in nerve associated with nerve growth factor and qutenza
18) Confidence 0.75 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16304633 Disease Relevance 0.56 Pain Relevance 0.74
Increased TRPA1, TRPM8, and TRPV2 expression in dorsal root ganglia by nerve injury.
Gene_expression (expression) of TRPM8 in dorsal root ganglia associated with nervous system injury
19) Confidence 0.75 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 17517374 Disease Relevance 0.47 Pain Relevance 0.37
Units in superficial Vc receive convergent input from primary afferents that express TRPM8, TRPA1, and/or TRPV1 channels, either directly or indirectly via intersubnuclear pathways.
Gene_expression (express) of TRPM8
20) Confidence 0.75 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17151223 Disease Relevance 0 Pain Relevance 0.19

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