INT117633

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Context Info
Confidence 0.79
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.23
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
peripheral nerve 1
Trpm8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 6 99.76 Very High Very High Very High
dorsal root ganglion 5 99.76 Very High Very High Very High
TRP channel 6 99.62 Very High Very High Very High
Rostral ventromedial medulla 16 96.08 Very High Very High Very High
qutenza 48 96.04 Very High Very High Very High
Periaqueductal grey 32 95.92 Very High Very High Very High
Antinociceptive 15 95.36 Very High Very High Very High
analgesia 17 93.40 High High
addiction 2 92.68 High High
Hyperalgesia 11 91.48 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.76 Very High Very High Very High
Nociception 22 97.00 Very High Very High Very High
Urological Neuroanatomy 32 95.92 Very High Very High Very High
Hyperalgesia 22 91.48 High High
Fever 10 75.60 Quite High
Pain 50 63.60 Quite High
Neuropathic Pain 40 50.00 Quite Low
Targeted Disruption 3 36.12 Quite Low
Central Nervous System Disease 1 34.40 Quite Low
INFLAMMATION 24 32.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Icilin, the peripheral cold channel agonist, activates TRPM8 and TRPA1, localized on dorsal root ganglia and trigeminal neurons in rats.
Localization (localized) of TRPM8 in neurons associated with agonist
1) Confidence 0.79 Published 2006 Journal Amino Acids Section Abstract Doc Link 16622598 Disease Relevance 0 Pain Relevance 0.29
This colocalization of TRPV1 and TRPM8 in a DRG neuron may be the basis for the paradoxical cold sensation.
Localization (colocalization) of TRPM8 in neuron associated with dorsal root ganglion
2) Confidence 0.79 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15050705 Disease Relevance 0.46 Pain Relevance 0.37
We propose a scheme in which Group II/III mGluRs would respond to glutamate released from TRPM8-containing afferents to exert an inhibitory gate control over nociceptive inputs.
Localization (released) of TRPM8-containing
3) Confidence 0.75 Published 2006 Journal Curr. Biol. Section Body Doc Link 16920620 Disease Relevance 0.06 Pain Relevance 0
Indeed, TRPM8 acted as a coincidence detector of icilin and calcium in that a rise in intracellular calcium, either through influx via TRPM8 or release from intracellular stores, was required for icilin-induced TRPM8 currents.
Localization (release) of TRPM8
4) Confidence 0.50 Published 2005 Journal Mol Pain Section Body Doc Link PMC1087877 Disease Relevance 0 Pain Relevance 0.40
Thus, TRPV1 receptor (and hopefully other TRP channels such as TRPA1 and TRPM8 which often co-localize with TRPV1 on peripheral nerve terminals) may offer a suitable target for enhancing the activity of the endogenous antinociceptive descending pathway and producing analgesia.
Localization (localize) of TRPM8 in peripheral nerve associated with trp channel, antinociceptive and analgesia
5) Confidence 0.23 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.71 Pain Relevance 1.36

General Comments

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