INT117636

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Context Info
Confidence 0.23
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnfrsf11b) extracellular region (Tnfrsf11b) proteinaceous extracellular matrix (Tnfrsf11b)
extracellular matrix organization (Tnfrsf11b)
Anatomy Link Frequency
osteoclast 1
Tnfrsf11b (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 97.84 Very High Very High Very High
fibrosis 2 95.88 Very High Very High Very High
cytokine 2 68.32 Quite High
palliative 1 65.04 Quite High
Disease Link Frequency Relevance Heat
Osteosclerosis 3 99.58 Very High Very High Very High
Hypercalcemia 1 99.48 Very High Very High Very High
Spontaneous Fractures 1 98.72 Very High Very High Very High
Pain 1 97.84 Very High Very High Very High
Fibrosis 2 95.88 Very High Very High Very High
Malignant Neoplastic Disease 1 94.80 High High
Multiple Myeloma 1 93.68 High High
Myelofibrosis 7 81.08 Quite High
Disease 1 78.20 Quite High
Bone Cancer 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 12 weeks of treatment, bortezomib also impaired osteosclerosis development through osteoprotegerin inhibition.
Negative_regulation (inhibition) of osteoprotegerin associated with osteosclerosis
1) Confidence 0.23 Published 2007 Journal Blood Section Abstract Doc Link 17374740 Disease Relevance 0.94 Pain Relevance 0.21
Osteoprotegerin (OPG) is a potent inhibitor of osteoclast differentiation and activation, but is limited as a therapeutic agent due to its short circulating half-life.
Negative_regulation (limited) of Osteoprotegerin in osteoclast
2) Confidence 0.20 Published 2004 Journal Exp. Hematol. Section Abstract Doc Link 15050745 Disease Relevance 0.63 Pain Relevance 0.10

General Comments

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