INT11764

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.61
First Reported 1983
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 78
Total Number 82
Disease Relevance 27.65
Pain Relevance 33.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENG) cell motility (ENG) cell adhesion (ENG)
nucleolus (ENG) nucleus (ENG) cytoplasm (ENG)
Anatomy Link Frequency
plasma 16
CSF 2
brain 2
Pit 2
neuronal 2
ENG (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 219 100.00 Very High Very High Very High
Enkephalin 68 100.00 Very High Very High Very High
Dopamine 49 100.00 Very High Very High Very High
Pain threshold 44 100.00 Very High Very High Very High
opiate 23 100.00 Very High Very High Very High
electroacupuncture 88 99.98 Very High Very High Very High
Morphine 73 99.98 Very High Very High Very High
noradrenaline 20 99.98 Very High Very High Very High
Clonidine 4 99.98 Very High Very High Very High
rheumatoid arthritis 141 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 253 100.00 Very High Very High Very High
Fibromyalgia 6 100.00 Very High Very High Very High
Stress 132 99.98 Very High Very High Very High
Death 95 99.98 Very High Very High Very High
Nervous System Injury 3 99.98 Very High Very High Very High
Rheumatoid Arthritis 142 99.84 Very High Very High Very High
Pre-eclampsia 200 99.76 Very High Very High Very High
Disease 163 99.76 Very High Very High Very High
Injury 33 99.68 Very High Very High Very High
INFLAMMATION 278 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, compared to a no EPI control group the EPI group had a significantly reduced i beta END response to the stressor, as evaluated by comparison of plasma levels at individual time points, maximal increases in plasma i beta END levels, and areas under the time-response curve.
Positive_regulation (increases) of END in EPI
1) Confidence 0.61 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2527244 Disease Relevance 0.31 Pain Relevance 0.08
Increases in soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) contribute to the pathogenesis of pre-eclampsia.
Positive_regulation (Increases) of sEng associated with fibromyalgia and eclampsia
2) Confidence 0.46 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.35 Pain Relevance 0.06
Activation of serotonin 5-HT1A receptors has been shown to increase plasma beta-endorphin (beta-END) levels in animal studies and in healthy humans.
Positive_regulation (increase) of beta-END in plasma associated with serotonin
3) Confidence 0.42 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18725263 Disease Relevance 0.10 Pain Relevance 0.31
Increases in soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) contribute to the pathogenesis of pre-eclampsia.
Positive_regulation (Increases) of soluble endoglin associated with fibromyalgia and eclampsia
4) Confidence 0.40 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.35 Pain Relevance 0.06
Tissue samples from patients with lung cancer were examined by immunohistochemistry to identify the components of the opioid network: beta-endorphin (END); its precursor, proopiomelanocortin (POMC); the key processing enzymes prohormone convertase 1 and 2; carboxypeptidase E; and END's corresponding opioid receptor, the mu-opioid receptor (MOR).
Positive_regulation (enzymes) of END in lung associated with lung cancer, opioid receptor and opioid
5) Confidence 0.39 Published 2010 Journal Pharmacol Rep Section Abstract Doc Link 20360624 Disease Relevance 0.26 Pain Relevance 0.87
In contrast, patients with acute pain showed significantly increased levels of beta-End in plasma.
Positive_regulation (increased) of beta-End in plasma associated with acute pain
6) Confidence 0.37 Published 1988 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 2972025 Disease Relevance 0.28 Pain Relevance 0.36
The results suggest that the increase in plasma levels of beta-End was a consequence of the stress produced by acute pain.
Positive_regulation (increase) of beta-End in plasma associated with stress and acute pain
7) Confidence 0.37 Published 1988 Journal Rev. Esp. Fisiol. Section Abstract Doc Link 2972025 Disease Relevance 0.45 Pain Relevance 0.35
METHODS: The beta-END response to the 5-HT1A receptor agonist, buspirone (30 mg), was measured in 30 patients with major depression and in 30 age- and sex-matched healthy controls before and after an 8-week treatment with citalopram.
Positive_regulation (response) of beta-END
8) Confidence 0.30 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Body Doc Link 18725263 Disease Relevance 0 Pain Relevance 0
Recent data suggests that such a regulatory role also exists for the endogenous opiate, beta-endorphin (beta-END).
Positive_regulation (exists) of beta-END associated with opiate
9) Confidence 0.30 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15191559 Disease Relevance 0 Pain Relevance 0.41
A promising discovery in terms of predicting the condition was that levels of sEng are elevated several weeks before the development of clinical symptoms in women who developed preeclampsia; furthermore, in patients who developed preterm preeclampsia, the serum sEng levels are elevated (approximately twofold) as early as gestational weeks 17-20 (Levine et al. 2006).
Positive_regulation (elevated) of sEng associated with pre-eclampsia
10) Confidence 0.28 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 0.76 Pain Relevance 0
Rana et al. (2007) found that although levels of sEng and sFLT-1 were found to be elevated in the serum of preeclamptic women at 17-20 weeks gestation when compared to controls, the levels at 11-13 weeks were similar between cases and controls.
Positive_regulation (elevated) of sEng
11) Confidence 0.28 Published 2008 Journal Trends Cardiovasc Med Section Body Doc Link PMC2577131 Disease Relevance 0.67 Pain Relevance 0
Three hours after incision, the level of end-tidal CO2 was elevated to 55 mmHg.
Positive_regulation (elevated) of end-tidal
12) Confidence 0.23 Published 2008 Journal J Anesth Section Abstract Doc Link 19011791 Disease Relevance 0.58 Pain Relevance 0.17
The endoglin ligand (transforming growth factor beta 1), however, is upregulated on RA synovial endothelial cells compared with OA and normal endothelial cells [83].
Positive_regulation (upregulated) of endoglin in endothelial cells associated with rheumatoid arthritis and osteoarthritis
13) Confidence 0.20 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 1.15 Pain Relevance 0.44
In the other 5 patients, at the outset of the study, a mild reduction in spirometric variables and restrictive impairment was seen, which increased until the end of the study (FVC range between 47% and 55%).
Positive_regulation (increased) of end
14) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2377332 Disease Relevance 0.69 Pain Relevance 0
Endoglin is an accessory TGF-?
Positive_regulation (accessory) of Endoglin
15) Confidence 0.19 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.51 Pain Relevance 0
This is important, as genistein can therapeutically compensate for endoglin loss, which occurs in prostate cancer progression.
Positive_regulation (compensate) of endoglin associated with reprotox - general 1
16) Confidence 0.19 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.50 Pain Relevance 0
m section that contained lesions of interest was prepared to hematoxylin and eosin-staining and CD31 and CD105 immunohistochemistry staining for analysis.
Positive_regulation (staining) of CD105
17) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267739 Disease Relevance 0.11 Pain Relevance 0.05
The effects of beta-endorphin(beta-End), an endogenous opioid, were tested in vitro on shape changes in polymorphonuclear leukocytes (PMNs).
Positive_regulation (effects) of beta-End in polymorphonuclear leukocytes associated with endogenous opioid
18) Confidence 0.16 Published 1985 Journal Immunobiology Section Abstract Doc Link 4043991 Disease Relevance 0 Pain Relevance 0.30
CRH increased levels of beta-END IRM, beta-END(1-31) and beta-LPH IRM.
Positive_regulation (increased) of beta-END IRM
19) Confidence 0.15 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16534240 Disease Relevance 0.61 Pain Relevance 1.03
CRH increased levels of beta-END IRM, beta-END(1-31) and beta-LPH IRM.
Positive_regulation (increased) of beta-END
20) Confidence 0.15 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 16534240 Disease Relevance 0.61 Pain Relevance 1.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox