INT117642

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 7.09
Pain Relevance 8.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
retina 2
brain 2
hippocampus 2
neural 2
eye 2
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 238 100.00 Very High Very High Very High
allodynia 14 100.00 Very High Very High Very High
chemokine 7 100.00 Very High Very High Very High
Peripheral nerve injury 7 100.00 Very High Very High Very High
glial activation 2 100.00 Very High Very High Very High
Pain 20 99.92 Very High Very High Very High
Neuronal excitability 9 99.88 Very High Very High Very High
Central nervous system 45 99.68 Very High Very High Very High
alcohol 22 99.24 Very High Very High Very High
Spinal cord 28 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 62 100.00 Very High Very High Very High
Neuropathic Pain 15 100.00 Very High Very High Very High
Nervous System Injury 7 100.00 Very High Very High Very High
Repression 201 98.96 Very High Very High Very High
Pain 57 98.00 Very High Very High Very High
Urological Neuroanatomy 57 95.92 Very High Very High Very High
Sprains And Strains 8 95.32 Very High Very High Very High
Drug Dependence 47 95.16 Very High Very High Very High
Cerebellar Diseases 3 94.96 High High
Congenital Anomalies 9 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of NR1 and the composition of the NR2 subunits are developmentally regulated.
Regulation (regulated) of Gene_expression (expression) of NR1
1) Confidence 0.53 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.57
Design and evaluation of small interfering RNAs that target expression of the N-methyl-D-aspartate receptor NR1 subunit gene in the spinal cord dorsal horn.
Regulation (target) of Gene_expression (expression) of NR1 in spinal cord dorsal horn associated with nmda receptor, dorsal horn and spinal cord
2) Confidence 0.42 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 17551091 Disease Relevance 0.34 Pain Relevance 0.59
NR1 expression and NR2A/B composition are altered in the rdta retina
Regulation (altered) of Gene_expression (expression) of NR1 in retina
3) Confidence 0.39 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.06 Pain Relevance 0.05
Alterations in synaptic NMDAR-mediated currents in PrP-null mice
Regulation (Alterations) of Gene_expression (currents) of NMDAR-mediated
4) Confidence 0.33 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.08 Pain Relevance 0.24
Thus, the morphological changes observed in dendritic spines may have been a result of the observed decreases in the expression of the NR1, PSD-95, p-CaMKII, and PAK families.
Regulation (result) of Gene_expression (expression) of NR1 in spines
5) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.66 Pain Relevance 0.19
The role of the N-methyl-D-aspartate receptor NR1 subunit in peripheral nerve injury-induced mechanical allodynia, glial activation and chemokine expression in the mouse.
Regulation (role) of Gene_expression (expression) of NR1 in peripheral nerve associated with chemokine, nervous system injury, allodynia, nmda receptor, glial activation and peripheral nerve injury
6) Confidence 0.27 Published 2004 Journal Neuroscience Section Title Doc Link 15051165 Disease Relevance 0.78 Pain Relevance 1.04
In conclusion, the present study was the first to demonstrate that PSD-93 deletion has distinct effects on synaptic NMDAR expression in the CNS.
Regulation (effects) of Gene_expression (expression) of NMDAR associated with central nervous system
7) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.78 Pain Relevance 1.28
The latter study supports the notion that neural activity is a regulating factor for NR1 expression.
Regulation (regulating) of Gene_expression (expression) of NR1 in neural
8) Confidence 0.23 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.19
NR1 expression is not altered in the dark-reared visual cortex [24,25] but contrarily, an intraocular injection of tetrodotoxin (TTX) does increase NR1-antibody binding in layer IV of the cortical column driven by the blocked eye [41].
Neg (not) Regulation (altered) of Gene_expression (expression) of NR1 in eye associated with tetrodotoxin
9) Confidence 0.23 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.10
The decrease in expression was not associated with any significant change in expression of NR1 or NR2B.
Regulation (change) of Gene_expression (expression) of NR1
10) Confidence 0.22 Published 2006 Journal Dev. Neurosci. Section Abstract Doc Link 16679770 Disease Relevance 0.33 Pain Relevance 0.52
Thus, these regulatory elements found in NR1 E21 are controlling an ensemble of exons whose splicing is modulated in excitable cells.
Regulation (controlling) of Gene_expression (found) of NR1
11) Confidence 0.21 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.39 Pain Relevance 0
These differences in the effects of aging on NMDA receptor expression in the synaptic pool versus the whole tissue are similar to those found in Fisher 344 rats, in which the basal surface expression of NMDA subunit proteins does not change between adult ages [71], but expression of both NR1 (?
Neg (not) Regulation (change) of Gene_expression (expression) of NR1 associated with aging and nmda receptor
12) Confidence 0.19 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0.38 Pain Relevance 0.32
As seen previously, and unlike the BK channel STREX exon or NR1 exon 5, the E21 3?
Regulation (exon) of Gene_expression (exon) of NR1
13) Confidence 0.19 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.36 Pain Relevance 0
As seen previously, and unlike the BK channel STREX exon or NR1 exon 5, the E21 3?
Regulation (unlike) of Gene_expression (exon) of NR1
14) Confidence 0.19 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0.41 Pain Relevance 0
Because PSD-93 deletion does not affect synaptic NMDAR expression and NMDAR-mediated postsynaptic functions in these two non-pain-related regions [17], PSD-93 deletion does not produce hippocampal and cerebellar dysfunctions, but does attenuate the development of persistent pain and morphine tolerance and physical dependence.
Neg (not) Regulation (affect) of Gene_expression (expression) of NMDAR associated with cerebellar diseases, pain, physical dependence, lasting pain, tolerance and morphine
15) Confidence 0.18 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 1.30 Pain Relevance 1.64
An important observation in the present study is that PSD-93 deficiency produces distinct effects on synaptic NMDAR expression in different regions of the CNS.
Regulation (effects) of Gene_expression (expression) of NMDAR associated with central nervous system
16) Confidence 0.16 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.46 Pain Relevance 0.75
It should be noted that Long-Evans rats do not show significant effects of aging on NR1 protein expression either by Western blotting of homogenates or immunofluorescence on tissue sections [72], so there appear to be some strain and species differences in the effects of aging on NMDA receptor expression in the hippocampus.
Neg (not) Regulation (effects) of Gene_expression (expression) of NR1 protein in hippocampus associated with aging, nmda receptor, hippocampus and sprains and strains
17) Confidence 0.13 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1919384 Disease Relevance 0.76 Pain Relevance 0.28
In addition, the effects of ethanol on the expression of NR1 isoforms might differ in each brain region.
Regulation (effects) of Gene_expression (expression) of NR1 in brain
18) Confidence 0.06 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0 Pain Relevance 0.19
Several reports have described the modulation of expression of specific NR1 isoforms by ethanol [54,57,71–77].
Regulation (modulation) of Gene_expression (expression) of NR1
19) Confidence 0.06 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872348 Disease Relevance 0 Pain Relevance 0.15

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