INT11766

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.27
Pain Relevance 12.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (H2-Ab1) plasma membrane (H2-Ab1) intracellular (H2-Ab1)
transcription factor binding (H2-Ab1)
Anatomy Link Frequency
neurons 1
nerve 1
plaque 1
skin 1
Mere 1
H2-Ab1 (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 31 100.00 Very High Very High Very High
c fibre 17 100.00 Very High Very High Very High
antagonist 9 100.00 Very High Very High Very High
mu opioid receptor 3 100.00 Very High Very High Very High
Adelta 11 99.92 Very High Very High Very High
Antinociceptive 5 99.74 Very High Very High Very High
Spinal nerve ligature 1 99.64 Very High Very High Very High
induced neuropathy 2 99.60 Very High Very High Very High
local anesthetic 1 99.56 Very High Very High Very High
Morphine 12 99.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 99.60 Very High Very High Very High
Hyperalgesia 8 99.36 Very High Very High Very High
Urological Neuroanatomy 5 98.44 Very High Very High Very High
Pain 16 96.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 96.88 Very High Very High Very High
Amyloid Plaque 3 95.52 Very High Very High Very High
Targeted Disruption 1 94.08 High High
INFLAMMATION 2 88.28 High High
Ganglion Cysts 1 87.96 High High
Nociception 7 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Impaired Abeta and C sensory function also extends into areas of skin that are not perceived as affected by pain.
Negative_regulation (Impaired) of Abeta in skin associated with pain and abeta
1) Confidence 0.43 Published 2007 Journal J Pain Section Abstract Doc Link 17175202 Disease Relevance 0.75 Pain Relevance 0.93
(D-Thr(6), D-Trp(8, 9), 15-ol)-galanin (1-15) applied alone (0.3-30 nmol/50 microl) to a separate population of neurones inhibited Abeta responses but enhanced post-discharge and wind-up in a similar pattern to galanin.
Negative_regulation (inhibited) of Abeta associated with abeta
2) Confidence 0.42 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11078928 Disease Relevance 0.08 Pain Relevance 0.70
In mature substantia gelatinosa neurons, C- and Adelta-afferent inputs were increased in number (to 84% and 86%, respectively), while Abeta-inputs were decreased to 9%.
Negative_regulation (decreased) of Abeta in substantia gelatinosa associated with adelta, substantia gelatinosa neuron and abeta
3) Confidence 0.37 Published 2000 Journal Neuroscience Section Abstract Doc Link 11029546 Disease Relevance 0.09 Pain Relevance 0.81
These data indicate that bortezomib-induced neuropathy is associated with deficits in Abeta, Adelta, and C caliber primary afferent fibers.
Negative_regulation (deficits) of Abeta associated with primary afferent fibers, adelta, induced neuropathy, neuropathic pain and abeta
4) Confidence 0.37 Published 2007 Journal J Pain Section Abstract Doc Link 17175202 Disease Relevance 0.70 Pain Relevance 0.97
Following chronic administration of clenbuterol (5 mg/kg daily for 14 days), a procedure resulting in down-regulation of central beta-adrenoceptors, a larger dose of clenbuterol was necessary to enhance the quipazine-induced hyperactivity, suggesting that the mechanism of enhancement involved central post-synaptic beta-adrenoceptors.
Negative_regulation (down-regulation) of beta-adrenoceptors associated with attention deficit hyperactivity disorder
5) Confidence 0.34 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6225031 Disease Relevance 0.26 Pain Relevance 0.30
Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration.
Negative_regulation (removal) of Abeta in plaque associated with abeta
6) Confidence 0.33 Published 2004 Journal Neurobiol. Dis. Section Title Doc Link 14751766 Disease Relevance 0.51 Pain Relevance 0.49
Considering the proposed model, wind-up in hyperalgesic states might leave out in three different ways: (1) blocking the NMDA receptors by increasing extracellular Mg2+, 2) blocking the receptors and channels that contribute to Ca2+ inward current, and 3) blocking the Abeta fibers by local anesthetics.
Negative_regulation (blocking) of Abeta associated with hyperalgesia, nmda receptor, local anesthetic and abeta
7) Confidence 0.16 Published 2006 Journal Med. Hypotheses Section Abstract Doc Link 16563645 Disease Relevance 0.58 Pain Relevance 0.60
The antinociceptive activity of beta-lactotensin was blocked by treatment with the neurotensin NT2 receptor antisense ODN, while treatment with the NT1 receptor antisense ODN had no effect.
Negative_regulation (blocked) of beta-lactotensin associated with antinociceptive
8) Confidence 0.12 Published 2003 Journal Life Sci. Section Abstract Doc Link 12899917 Disease Relevance 0 Pain Relevance 0.68
Mere confrontation with a non-aggressive opponent failed to induce analgesia and was associated in C57BL/6 mice with a significant reduction in the beta-ELIR content of both the pituitary and the PAG.
Negative_regulation (reduction) of beta-ELIR in Mere associated with periaqueductal grey and analgesia
9) Confidence 0.11 Published 1988 Journal Brain Res. Section Abstract Doc Link 3401713 Disease Relevance 0.88 Pain Relevance 0.79
Lignocaine produced dose-dependent inhibitions of the C-, A-delta and A-beta evoked responses of the cells which became more selective for the noxious evoked responses as the dose increased.
Negative_regulation (inhibitions) of A-beta
10) Confidence 0.07 Published 1992 Journal Pain Section Abstract Doc Link 1594281 Disease Relevance 0.16 Pain Relevance 0.76
Local bath application of 2.0 mg/ml WIN significantly reduced PDC activity (3+/-1% control, P<0.01), C-fiber evoked activity (58+/-9% control, P<0.01), and Abeta evoked activity (57+/-10% control, P<0.01) in WDR neurons.
Negative_regulation (reduced) of Abeta in neurons associated with c fibre, wide dynamic range and abeta
11) Confidence 0.05 Published 2004 Journal Pain Section Abstract Doc Link 14736589 Disease Relevance 0.22 Pain Relevance 1.39
Continuous exposure to DAMGO also significantly increased DBI mRNA expression, which was completely abolished by a selective antagonist of mu-opioid receptors, beta-funaltrexamine (beta-FNA).
Negative_regulation (antagonist) of beta-FNA associated with antagonist and mu opioid receptor
12) Confidence 0.05 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17638297 Disease Relevance 0 Pain Relevance 1.04
The increased CREB activation associated with thermal hyperalgesia was accompanied by significant decreases in the content of both calcineurin Aalpha and Abeta.
Negative_regulation (decreases) of Abeta associated with thermal hyperalgesia and abeta
13) Confidence 0.04 Published 2002 Journal Pain Section Abstract Doc Link 12406525 Disease Relevance 0.93 Pain Relevance 1.08
Following either sham surgery, or spinal nerve ligation, spinal muscimol inhibited Abeta-, Adelta- and C-fibre evoked responses of spinal neurones to a similar extent, however significant inhibitory effects on the post-discharge response were not observed in nerve injured rats.
Negative_regulation (inhibited) of Abeta in nerve associated with c fibre, adelta, spinal nerve ligature and abeta
14) Confidence 0.03 Published 2003 Journal Brain Res. Section Abstract Doc Link 12543472 Disease Relevance 0.11 Pain Relevance 1.27
However, depletion of beta-arrestins almost totally blocked both internalization and AC desensitization of DTS.
Negative_regulation (depletion) of beta-arrestins
15) Confidence 0.01 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17565992 Disease Relevance 0 Pain Relevance 0.52

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