INT117661

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.69
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd22) plasma membrane (Cd22)
Anatomy Link Frequency
B-cells 5
mature B-cells 1
marginal zone 1
blast cells 1
Cd22 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 31 98.60 Very High Very High Very High
Pain 3 91.40 High High
rheumatoid arthritis 10 88.28 High High
abdominal pain 4 86.88 High High
vincristine 4 77.60 Quite High
cva 13 72.20 Quite High
iatrogenic 2 19.04 Low Low
ischemia 1 12.84 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
abatacept 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 119 99.58 Very High Very High Very High
Chronic Lymphoid Leukemia 24 98.60 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.52 Very High Very High Very High
Hyperplasia 4 96.80 Very High Very High Very High
Systemic Lupus Erythematosus 134 95.84 Very High Very High Very High
Splenomegaly 8 95.56 Very High Very High Very High
Thrombocytopenia 3 93.04 High High
Leukopenia 1 92.20 High High
Anaemia 2 91.72 High High
Arthralgia 4 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Neg (negative) Gene_expression (negative) of CD22 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
1) Confidence 0.30 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.15 Pain Relevance 0
CD22 is expressed on pro-B-cells, pre-B-cells, and mature B-cells, and unlike CD20, delivers and modifies intracellular signalling.
Gene_expression (expressed) of CD22 in B-cells
2) Confidence 0.21 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.75 Pain Relevance 0.08
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, CD10(dim), surface IgG, HLA-DR and CD43, but negative for CD5, CD34, and tdT.
Neg (negative) Gene_expression (expressing) of CD22 in B cell
3) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.04 Pain Relevance 0.07
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, HLA-DR and kappa, but negative for CD5, CD10, CD23, and CD34, and tdT.
Neg (negative) Gene_expression (expressing) of CD22 in B cell
4) Confidence 0.11 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.03 Pain Relevance 0.19
CD22 is expressed on pro-B-cells, pre-B-cells, and mature B-cells, and unlike CD20, delivers and modifies intracellular signalling.
Gene_expression (expressed) of CD22 in mature B-cells
5) Confidence 0.07 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2943198 Disease Relevance 0.75 Pain Relevance 0.08
B-cells expressed CD5, CD19, CD20, CD21 (partial), CD22, CD23, CD11c (partial) and CD52, consistent with CLL.
Gene_expression (expressed) of CD22 in B-cells associated with chronic lymphoid leukemia
6) Confidence 0.07 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2923171 Disease Relevance 0.35 Pain Relevance 0.04
The examination of a bone marrow aspirate revealed the predominance of blast cells (97%) with FAB L1 morphology, immunopheno-typically positive for CD19 (95%), CD10 (95%), CD22 (95%), CD13 (82%), CD34 (95%) and CD38 (72%), with dim expression of CD45 and of the intracellular antigen terminal deoxynucleotidyl transferase (Tdt).
Gene_expression (expression) of CD22 in blast cells
7) Confidence 0.07 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 15053308 Disease Relevance 0.60 Pain Relevance 0.09
Anne Krug found that PDCs synergistically enhance activation and cytokine production of human peripheral blood B cells that were stimulated by B-cell receptor ligation (anti-Ig) and a microbial molecular (CpG) [36].
Gene_expression (ligation) of B-cell receptor in B-cell associated with cytokine
8) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0 Pain Relevance 0.08

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