INT117662

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Context Info
Confidence 0.69
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 18.76
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ABL1) protein modification process (ABL1) mitochondrion (ABL1)
nucleolus (ABL1) nucleus (ABL1) DNA binding (ABL1)
Anatomy Link Frequency
plasma 1
myeloid progenitor cells 1
reproductive system 1
Muscle 1
Blast cells 1
ABL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 5 77.80 Quite High
Pain 20 77.04 Quite High
Demyelination 5 69.92 Quite High
antagonist 7 68.80 Quite High
Spinal cord 5 55.44 Quite High
palliative 5 51.20 Quite High
Inflammation 21 43.92 Quite Low
metalloproteinase 4 43.00 Quite Low
cytokine 24 34.00 Quite Low
qutenza 1 22.76 Low Low
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 148 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 7 100.00 Very High Very High Very High
Cancer 286 99.98 Very High Very High Very High
Leukemia 109 99.98 Very High Very High Very High
Myeloid Leukemia 207 99.96 Very High Very High Very High
Ovarian Cancer 102 99.74 Very High Very High Very High
Apoptosis 192 99.32 Very High Very High Very High
Philadelphia Chromosome 12 99.22 Very High Very High Very High
Gastrointestinal Stromal Tumor 3 99.20 Very High Very High Very High
Myelodysplastic Syndromes 138 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At oral doses of 200-600 mg, the majority of patients with chronic myeloid leukaemia, Philadelphia chromosome-positive acute lymphoblastic leukemia expressing the BCR-ABL fusion protein and gastrointestinal stromal tumours (GIST) achieve a bio-molecular and clinical response, frequently complete, associated with limited toxicity.
Gene_expression (expressing) of ABL associated with toxicity, leukemia, philadelphia chromosome and gastrointestinal stromal tumor
1) Confidence 0.69 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 16767900 Disease Relevance 1.34 Pain Relevance 0.05
Patients with Ph Chromosome/BCR-ABL1 positive CML at any stage of the disease were eligible for enrolment in GIPAP irrespective of prior therapy.
Gene_expression (positive) of BCR-ABL1 associated with myeloid leukemia and disease
2) Confidence 0.61 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC3017013 Disease Relevance 0.99 Pain Relevance 0
Quantitative BCR/ABL by FISH repeated after 6 months showed partial cytogenetic response, but repeat analysis showed lack of response.
Gene_expression (/) of ABL
3) Confidence 0.61 Published 2010 Journal BMC Blood Disord Section Body Doc Link PMC3017013 Disease Relevance 0 Pain Relevance 0
Blast cells were lacking surface immunoglobulin expression and bcr/abl rearrangements were not detected.
Neg (not) Gene_expression (detected) of bcr/abl in Blast cells
4) Confidence 0.58 Published 2003 Journal J. Exp. Clin. Cancer Res. Section Abstract Doc Link 15053308 Disease Relevance 0.56 Pain Relevance 0.08
Muscle involvement in ABL affecting both striated and smooth muscle has been reported in some patients, and furthermore was the cause of premature death cases among a few ABL patients [28-30].
Gene_expression (affecting) of ABL in Muscle associated with death
5) Confidence 0.48 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.84 Pain Relevance 0.03
In 1993, the region on chromosome 4q22-24 that encodes the large subunit of MTP was cloned and sequenced, and human MTP mutations in ABL patients were reported [5].
Gene_expression (mutations) of ABL
6) Confidence 0.48 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.58 Pain Relevance 0
It is of interest that reproductive system manifestations seem to be rather minimal in ABL, indicating that in the absence of LDL, there is sufficient capacity for synthesis and secretion of steroid hormones, including sex steroids, provided by HDL.
Gene_expression (minimal) of ABL in reproductive system associated with disorder of lipid metabolism
7) Confidence 0.48 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 1.10 Pain Relevance 0
Regarding prognosis based upon age at diagnosis, many ABL patients present in the 2nd to 4th decades, while a few others present in the 1st and 6th decades.
Gene_expression (present) of ABL
8) Confidence 0.48 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.33 Pain Relevance 0
While obligate heterozygote parents of HHBL patients have half-normal plasma levels of apo B and LDL-cholesterol, obligate heterozygote parents of ABL patients have normal plasma lipoprotein profiles.
Gene_expression (levels) of ABL in plasma
9) Confidence 0.48 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2467409 Disease Relevance 0.77 Pain Relevance 0.03
By contrast, in the pre-ARF period no significant correlations were observed between Pto/Cro and BCrC, BUC, FeNa and FeK.


Gene_expression (/) of BCrC associated with acute renal failure and disorders of creatine metabolism
10) Confidence 0.42 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.49 Pain Relevance 0
In addition to BCR-ABL1 gene amplification resulting in overexpression of BCR-ABL1 protein, or point mutations that prevent the binding of the inhibitor to the kinase domain [8, 9], several groups have demonstrated other forms of BCR-ABL1-independent imatinib resistance [10–12].
Gene_expression (overexpression) of BCR-ABL1
11) Confidence 0.42 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.88 Pain Relevance 0
Since gene expression quantification using RT-qPCR requires a steady reference gene, we selected three genes frequently used for normalization of the data, ABL1, RPLP0, and HPRT1.
Gene_expression (expression) of ABL1
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004942 Disease Relevance 0.54 Pain Relevance 0
The subsequent RT reaction was verified by a PCR reaction amplifying the ubiquitously expressed ABL transcript.
Gene_expression (expressed) of ABL
13) Confidence 0.38 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2861168 Disease Relevance 1.05 Pain Relevance 0
Recent studies indicate that HDACi are capable of attenuating the expression of BCR-ABL and of inducing apoptosis in both imatinib sensitive and resistant cell lines [64–69].
Gene_expression (expression) of BCR-ABL associated with apoptosis
14) Confidence 0.36 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.53 Pain Relevance 0
Chronic Myeloid Leukemia (CML) is a MPN of myeloid progenitor cells characterised by the expression of a 210-KDa fusion oncoprotein, BCR-ABL, resulting from the juxtapositioning of chromosomes 9 and 22 [the Philadelphia chromosome translocation, t(9;22)].
Gene_expression (expression) of BCR-ABL in myeloid progenitor cells associated with myeloproliferative disorder, myeloid leukemia, philadelphia chromosome and chronic myeloid leukemia
15) Confidence 0.32 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.99 Pain Relevance 0
They consist of eight families with the major ones including SRC, JAK, ABL, FAK (Levitzki 1999).


Gene_expression (ones) of ABL
16) Confidence 0.29 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 0.34 Pain Relevance 0
This translocation generates a fusion protein called BCR-ABL which
Gene_expression (generates) of BCR-ABL
17) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.34 Pain Relevance 0.03
These Hsp90 clients comprise kinases such as ERBB2, EGFR, CDK4, RAF, AKT, cMET and BCR-ABL, and transcription factors such as HIF-1?
Gene_expression (kinases) of BCR-ABL
18) Confidence 0.15 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.75 Pain Relevance 0
Hence the standard care for treating CML is to target Bcr Abl tyrosine kinase by the pharmacological inhibitors Imatinib or more potent Dasatinib and Nilotinib [17].
Gene_expression (tyrosine kinase) of Abl associated with myeloid leukemia
19) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 1.02 Pain Relevance 0
These agents are active against cells expressing a variety of BCR-ABL mutations, including T135I.
Gene_expression (expressing) of BCR-ABL
20) Confidence 0.10 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC3000369 Disease Relevance 0.70 Pain Relevance 0

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