INT117674

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 11.50
Pain Relevance 22.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 11
nociceptors 4
nerves 2
nodes 2
spinal cord 2
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.3 263 100.00 Very High Very High Very High
sodium channel 261 100.00 Very High Very High Very High
Nav1.6 218 100.00 Very High Very High Very High
nav1.8 202 100.00 Very High Very High Very High
Nav1.2 138 100.00 Very High Very High Very High
Nav1.1 57 100.00 Very High Very High Very High
beta nociceptor 4 99.96 Very High Very High Very High
unmyelinated 14 99.84 Very High Very High Very High
Lasting pain 34 99.76 Very High Very High Very High
nociceptor 25 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 169 99.76 Very High Very High Very High
Nociception 110 99.74 Very High Very High Very High
Convulsion 4 99.68 Very High Very High Very High
Ganglion Cysts 116 98.80 Very High Very High Very High
Neuropathic Pain 89 98.60 Very High Very High Very High
Cancer Pain 50 98.60 Very High Very High Very High
Injury 433 98.08 Very High Very High Very High
Hyperalgesia 48 98.04 Very High Very High Very High
Nervous System Injury 91 97.76 Very High Very High Very High
Cancer 83 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in the expression of Nav1.1 and Nav1.6 parallel age-dependent increases in seizure frequency and duration.
Regulation (Changes) of Gene_expression (expression) of Nav1 associated with convulsion, nav1.1 and nav1.6
1) Confidence 0.62 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.41 Pain Relevance 0.91
Furthermore, as revealed by immunofluorescence, only the expression of Nav1.8 protein in small neurons down regulated significantly in bilateral DRG of cancer pain rats.
Regulation (regulated) of Gene_expression (expression) of Nav1 in neurons
2) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link 20482896 Disease Relevance 0 Pain Relevance 0
No changes in expression of Nav1.3 were observed in other thalamic nuclei, such as the intralaminar nuclei [22], which is important in processing affective components of pain.
Neg (No) Regulation (changes) of Gene_expression (expression) of Nav1 associated with pain and nav1.3
3) Confidence 0.62 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.86 Pain Relevance 1.47
Changes in the expression, trafficking, and redistribution of Nav1.8 in chronic pain models are considered to account for abnormal firing and the generation of ectopic activity in afferent nerves [11].
Regulation (Changes) of Gene_expression (expression) of Nav1 in nerves associated with lasting pain, ectopic activity and nav1.8
4) Confidence 0.62 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 1.12 Pain Relevance 2.45
These findings suggest that in Aalpha/beta nociceptors, influences of NGF on expression levels of Nav1.8 are related to, and perhaps limited by, expression levels of trkA.
Regulation (influences) of Gene_expression (expression) of Nav1 in nociceptors associated with nav1.8 and beta nociceptor
5) Confidence 0.57 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15888662 Disease Relevance 0.20 Pain Relevance 1.47
Changes in the expression of Nav1.1 and Nav1.6 parallel age-dependent increases in seizure frequency and duration.
Regulation (Changes) of Gene_expression (expression) of Nav1 associated with convulsion, nav1.1 and nav1.6
6) Confidence 0.45 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.41 Pain Relevance 0.91
Third, while the up-regulated expression of Nav1.3 within DRG neurons following axotomy appears to be due in part to deprivation from peripheral pools of neurotrophic factors [29-31], the signals that trigger Nav1.3 upregulation within third-order neurons have not been identified.
Regulation (regulated) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3
7) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.33 Pain Relevance 0.97
Up-regulation of Nav1.3 expression in DRG neurons is associated with allodynia and hyperalgesia [8].
Regulation (regulation) of Gene_expression (expression) of Nav1 in neurons associated with nav1.3, hyperalgesia and allodynia
8) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.95 Pain Relevance 2.00
The fiber area ROI was then applied to the thresholded Nav1.6 image and the "Analyze Particles" function under the "Analyze" menu was employed to determine the total count and average size of accumulations that were ?
Regulation (thresholded) of Gene_expression (image) of Nav1.6 associated with nav1.6
9) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.59
The immunohistochemical alteration of Nav1.8 protein expression was parallel to the results of the mRNA expression.
Regulation (alteration) of Gene_expression (expression) of Nav1 associated with nav1.8
10) Confidence 0.43 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.50 Pain Relevance 1.19
trkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1.8 expression in rapidly conducting nociceptors.
Regulation (influences) of Gene_expression (expression) of Nav1 in nociceptors associated with nociception, nociceptor, neuropeptide and nav1.8
11) Confidence 0.42 Published 2005 Journal J. Neurosci. Section Title Doc Link 15888662 Disease Relevance 0.62 Pain Relevance 0.85
In sum, our findings demonstrate changes in excitability and expression of Nav1.3, but not other neuronal sodium channels (Nav1.1, Nav1.2, Nav1.6), within contralateral VPL neurons following CCI.
Regulation (changes) of in neurons Gene_expression (expression) of Nav1 in neuronal associated with nav1.3, nav1.1, eae, nav1.2, sodium channel and nav1.6
12) Confidence 0.27 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 1.16 Pain Relevance 2.24
Ten days after CCI, when allodynia and hyperalgesia were evident, in situ hybridization and immunocytochemical analysis revealed up-regulation of Nav1.3 mRNA, but no changes in expression of Nav1.1, Nav1.2, or Nav1.6 in VPL neurons, and unit recordings demonstrated increased background firing, which persisted after spinal cord transection, and evoked hyperresponsiveness to peripheral stimuli.
Neg (no) Regulation (changes) of Gene_expression (expression) of Nav1 in spinal cord associated with nav1.3, hyperalgesia, nav1.1, allodynia, eae, nav1.2, nav1.6 and spinal cord
13) Confidence 0.27 Published 2006 Journal Mol Pain Section Abstract Doc Link PMC1563449 Disease Relevance 1.10 Pain Relevance 1.48
Together with our earlier results on dorsal root ganglion [8] and dorsal horn neurons [9], these results provide evidence suggesting that dysregulated Nav1.3 expression at both spinal and supraspinal levels after peripheral nerve injury contributes to altered processing of somatosensory information and chronic neuropathic pain.


Regulation (dysregulated) of Gene_expression (expression) of Nav1 in dorsal root ganglion associated with ganglion cysts, nav1.3, dorsal root ganglion, nervous system injury, neuropathic pain, dorsal horn neuron and peripheral nerve injury
14) Confidence 0.27 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 1.15 Pain Relevance 1.96
Naturally, possible changes in the expression of Nav1.6 in unmyelinated fibers would be important to evaluate in the future since altered activity after inflammatory and axotomy lesions most likely involves contributions from both myelinated and unmyelinated axons.
Spec (possible) Regulation (changes) of Gene_expression (expression) of Nav1.6 associated with inflammation, unmyelinated and nav1.6
15) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0.31 Pain Relevance 0.91
Furthermore, as revealed by immunofluorescence, only the expression of Nav1.8 protein in small neurons down regulated significantly in bilateral DRG of cancer pain rats.
Regulation (regulated) of Gene_expression (expression) of Nav1 in neurons associated with cancer pain and nav1.8
16) Confidence 0.27 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2894792 Disease Relevance 1.32 Pain Relevance 1.51
We have hypothesized that altered local expression of NaV1.8 in the peripheral axons of DRG neurons could facilitate nociceptive signal generation and propagation after neuropathic injury.


Regulation (altered) of Gene_expression (expression) of NaV1 in neurons associated with nociception, dorsal root ganglion, injury and neuropathic pain
17) Confidence 0.21 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2667430 Disease Relevance 1.06 Pain Relevance 0.82
It also possible that a ménage à trois between ankyrin G, Nav channels, and CK2 is involved in the sorting of these components to the AIS and nodes of Ranvier.
Regulation (involved) of Gene_expression (channels) of Nav in nodes
18) Confidence 0.20 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2600743 Disease Relevance 0 Pain Relevance 0.29

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