INT117675

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 46
Total Number 53
Disease Relevance 30.23
Pain Relevance 44.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 7
proximal 6
brains 4
nerves 4
cortex 4
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 1216 100.00 Very High Very High Very High
nav1.8 773 100.00 Very High Very High Very High
sodium channel 460 100.00 Very High Very High Very High
nav1.3 412 100.00 Very High Very High Very High
Nav1.2 134 100.00 Very High Very High Very High
Nav1.6 102 100.00 Very High Very High Very High
Nav1.1 102 100.00 Very High Very High Very High
Nav1.9 56 100.00 Very High Very High Very High
Pain 377 99.92 Very High Very High Very High
Eae 838 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 400 99.92 Very High Very High Very High
Inflammatory Pain 21 99.78 Very High Very High Very High
Injury 1438 99.76 Very High Very High Very High
Ganglion Cysts 977 99.68 Very High Very High Very High
Hypersensitivity 119 99.56 Very High Very High Very High
Cancer Pain 172 99.20 Very High Very High Very High
Nerve Compression Syndromes 651 98.92 Very High Very High Very High
Myocardial Infarction 7 98.32 Very High Very High Very High
Cancer 289 98.24 Very High Very High Very High
Carcinosarcoma 35 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization studies were performed on intact and CCI brains for detection of mRNA for neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 in the VPL.
Transcription (detection) of Nav1 in brains associated with nav1.3, nav1.1, eae, nav1.2, sodium channel and nav1.6
1) Confidence 0.72 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.54 Pain Relevance 1.14
In situ hybridization studies were performed on intact and CCI brains for detection of mRNA for neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 in the VPL.
Transcription (detection) of Nav1 in brains associated with nav1.3, nav1.1, eae, nav1.2, sodium channel and nav1.6
2) Confidence 0.72 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.54 Pain Relevance 1.08
In situ hybridization studies were performed on intact and CCI brains for detection of mRNA for neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 in the VPL.
Transcription (detection) of Nav1 in brains associated with nav1.3, nav1.1, eae, nav1.2, sodium channel and nav1.6
3) Confidence 0.72 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.54 Pain Relevance 1.13
In situ hybridization studies were performed on intact and CCI brains for detection of mRNA for neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 in the VPL.
Transcription (detection) of Nav1 in brains associated with nav1.3, nav1.1, eae, nav1.2, sodium channel and nav1.6
4) Confidence 0.72 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.54 Pain Relevance 1.14
In the WAG/Rij model of absence epilepsy, we identified a specific region of cortex, in layer II-IV neurons on the lateral convexity of the cortex in the facial somatosensory area, where mRNA and protein expression of sodium channel genes Nav1.1 and Nav1.6 are up-regulated.
Transcription (expression) of Nav1 in cortex associated with nav1.1, sodium channel, absence epilepsy and nav1.6
5) Confidence 0.69 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.32 Pain Relevance 0.97
In the WAG/Rij model of absence epilepsy, we identified a specific region of cortex, in layer II-IV neurons on the lateral convexity of the cortex in the facial somatosensory area, where mRNA and protein expression of sodium channel genes Nav1.1 and Nav1.6 are up-regulated.
Transcription (expression) of Nav1 in cortex associated with nav1.1, sodium channel, absence epilepsy and nav1.6
6) Confidence 0.69 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.32 Pain Relevance 0.97
Twelve micron transverse cryosections (n = 5 sections/animal) from each group were processed for detection of mRNA for the neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 as previously described [46,47], with incubation in 4% paraformaldehyde increased to 12 min and permeabilization with proteinase K reduced to 6 min.
Transcription (detection) of Nav1 in neuronal associated with nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
7) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.26 Pain Relevance 0.93
Twelve micron transverse cryosections (n = 5 sections/animal) from each group were processed for detection of mRNA for the neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 as previously described [46,47], with incubation in 4% paraformaldehyde increased to 12 min and permeabilization with proteinase K reduced to 6 min.
Transcription (detection) of Nav1 in neuronal associated with nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
8) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.26 Pain Relevance 0.93
Twelve micron transverse cryosections (n = 5 sections/animal) from each group were processed for detection of mRNA for the neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 as previously described [46,47], with incubation in 4% paraformaldehyde increased to 12 min and permeabilization with proteinase K reduced to 6 min.
Transcription (detection) of Nav1 in neuronal associated with nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
9) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.26 Pain Relevance 0.92
Twelve micron transverse cryosections (n = 5 sections/animal) from each group were processed for detection of mRNA for the neuronal sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.6 as previously described [46,47], with incubation in 4% paraformaldehyde increased to 12 min and permeabilization with proteinase K reduced to 6 min.
Transcription (detection) of Nav1 in neuronal associated with nav1.3, nav1.1, nav1.2, sodium channel and nav1.6
10) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.26 Pain Relevance 0.93
Neurons expressing Nav1.3 mRNA were localized to the VPL exclusively, and no signal was observed in the VPM, intralaminar, or adjacent thalamic nuclei.
Transcription (expressing) of Nav1 in Neurons associated with nav1.3
11) Confidence 0.69 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563449 Disease Relevance 0.51 Pain Relevance 1.12
Tetrodotoxin-resistant (TTX-R) sodium-channel Nav1.8 mRNA expression was significantly decreased and TTX-R sodium-channel Nav1.9 mRNA expression showed a tendency to decrease when compared with the mRNA expressions in the control groups.
Transcription (expression) of Nav1 associated with tetrodotoxin, nav1.8 and nav1.9
12) Confidence 0.68 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.46 Pain Relevance 1.07
However, tetrodotoxin-sensitive (TTX-S) sodium-channel Nav1.3 mRNA expression remained unaltered.
Transcription (expression) of Nav1 associated with nav1.3 and tetrodotoxin
13) Confidence 0.68 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.48 Pain Relevance 1.18
Tetrodotoxin-resistant (TTX-R) sodium-channel Nav1.8 mRNA expression was significantly decreased and TTX-R sodium-channel Nav1.9 mRNA expression showed a tendency to decrease when compared with the mRNA expressions in the control groups.
Transcription (expression) of Nav1 associated with tetrodotoxin, nav1.8 and nav1.9
14) Confidence 0.68 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.44 Pain Relevance 0.99
The primary antibodies used were: anti-Pan Nav channel antibody for the first labeling step, and a mouse monoclonal anti-smooth muscle ?
Transcription (antibody) of Nav in smooth muscle
15) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.16
We identified three mRNA transcripts: two neuronal TTXS isoforms (Nav 1.2 and Nav 1.3), and the cardiac TTXR isoform Nav1.5.
Transcription (transcripts) of Nav1 in neuronal
16) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.32
We identified three mRNA transcripts: two neuronal TTXS isoforms (Nav 1.2 and Nav 1.3), and the cardiac TTXR isoform Nav1.5.
Transcription (transcripts) of Nav in neuronal
17) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.32
We identified three mRNA transcripts: two neuronal TTXS isoforms (Nav 1.2 and Nav 1.3), and the cardiac TTXR isoform Nav1.5.
Transcription (transcripts) of Nav in neuronal
18) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.32
The immunohistochemical alteration of Nav1.8 protein expression was parallel to the results of the mRNA expression.
Transcription (expression) of Nav1 associated with nav1.8
19) Confidence 0.65 Published 2010 Journal J. Orthop. Res. Section Abstract Doc Link 19877286 Disease Relevance 0.51 Pain Relevance 1.21
However, we did not observe increased NaV1.5 mRNA expression in the DRG or the sciatic nerve after SNE.
Transcription (expression) of NaV1 in sciatic nerve associated with dorsal root ganglion, nerve compression syndromes and sciatic nerve
20) Confidence 0.55 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.91 Pain Relevance 0.83

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