INT117676

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Context Info
Confidence 0.53
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.37
Pain Relevance 7.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cortex 6
peripheral nerve 4
sciatic nerve 2
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 112 100.00 Very High Very High Very High
sodium channel 57 100.00 Very High Very High Very High
Nav1.6 12 100.00 Very High Very High Very High
Nav1.1 12 100.00 Very High Very High Very High
Eae 76 99.98 Very High Very High Very High
dorsal root ganglion 170 99.68 Very High Very High Very High
Nav1.2 3 99.52 Very High Very High Very High
Sciatic nerve 221 99.24 Very High Very High Very High
tetrodotoxin 19 99.20 Very High Very High Very High
ectopic activity 1 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Inflammatory Pain 3 99.98 Very High Very High Very High
Nerve Compression Syndromes 124 99.96 Very High Very High Very High
Ganglion Cysts 170 99.68 Very High Very High Very High
Absence Epilepsy 6 96.72 Very High Very High Very High
Injury 165 95.08 Very High Very High Very High
Pain 41 93.76 High High
Convulsion 6 92.48 High High
Epilepsy 3 86.92 High High
Nervous System Injury 38 79.60 Quite High
Wallerian Degeneration 4 77.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we did not observe increased NaV1.5 mRNA expression in the DRG or the sciatic nerve after SNE.
Neg (not) Positive_regulation (increased) of Transcription (expression) of NaV1 in sciatic nerve associated with dorsal root ganglion, nerve compression syndromes and sciatic nerve
1) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.91 Pain Relevance 0.83
In the WAG/Rij model of absence epilepsy, we identified a specific region of cortex, in layer II-IV neurons on the lateral convexity of the cortex in the facial somatosensory area, where mRNA and protein expression of sodium channel genes Nav1.1 and Nav1.6 are up-regulated.
Positive_regulation (up-regulated) of Transcription (expression) of Nav1 in cortex associated with nav1.1, sodium channel, absence epilepsy and nav1.6
2) Confidence 0.50 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.33 Pain Relevance 0.97
In the WAG/Rij model of absence epilepsy, we identified a specific region of cortex, in layer II-IV neurons on the lateral convexity of the cortex in the facial somatosensory area, where mRNA and protein expression of sodium channel genes Nav1.1 and Nav1.6 are up-regulated.
Positive_regulation (up-regulated) of Transcription (expression) of Nav1 in cortex associated with nav1.1, sodium channel, absence epilepsy and nav1.6
3) Confidence 0.50 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.33 Pain Relevance 0.97
SWDs increased with age in WAG/Rij rats. mRNA levels for sodium channels Nav1.1 and Nav1.6, but not Nav1.2, were found to be up-regulated selectively within the facial somatosensory cortex (at AP +0.0, ML +6.0 mm).
Positive_regulation (increased) of Transcription (levels) of Nav1 in cortex associated with somatosensory cortex, nav1.1, nav1.2, sodium channel and nav1.6
4) Confidence 0.47 Published 2004 Journal Brain Res. Section Abstract Doc Link 15053958 Disease Relevance 0.23 Pain Relevance 0.78
Carrageenan-induced inflammatory pain increases Nav1.8 mRNA expression and the density of TTX-R currents [12].
Positive_regulation (increases) of Transcription (expression) of Nav1 associated with tetrodotoxin, eae and nav1.8
5) Confidence 0.47 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894792 Disease Relevance 0.97 Pain Relevance 2.40
Selectivity of peripheral nerve NaV1.8 mRNA up-regulation after SNE
Positive_regulation (after) of Transcription (Selectivity) of NaV1 in peripheral nerve associated with nerve compression syndromes
6) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.54 Pain Relevance 0.64
Selectivity of peripheral nerve NaV1.8 mRNA up-regulation after SNE
Positive_regulation (after) of Transcription (peripheral nerve) of NaV1 in peripheral nerve associated with nerve compression syndromes
7) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.53 Pain Relevance 0.64
Ipsilateral NaV1.6 mRNA expression was increased by 3.48-fold, but this difference did not reach statistical significance (p > 0.05, Mann-Whitney).
Positive_regulation (increased) of Transcription (expression) of NaV1
8) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.54 Pain Relevance 0.53

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