INT117683

Context Info Confidence 0.50 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.31 Pain Relevance 0.58

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)

Anatomy Link Frequency neurons 2 primary sensory neurons 2 GSTM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 6 99.74 mu opioid receptor 1 95.76 Antihyperalgesic 5 91.12 magnetoencephalography 6 84.72 Electroencephalography 17 83.40 MU agonist 3 75.00 Hyperalgesia 1 54.56 Pain 4 39.20 tail-flick 1 26.64 Acute pain 1 25.04

Disease Link Frequency Relevance Heat Sprains And Strains 40 99.98 INFLAMMATION 5 99.74 Nicotine Addiction 4 93.48 Severe Combined Immunodeficiency 6 81.92 Hyperalgesia 1 54.56 Pain 5 39.20 Ataxia 1 25.00 Multiple Chemical Sensitivity 20 5.00 Disease 11 5.00 Hypersensitivity 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Table 3 shows the distribution of NAT2, GSTM1, GSTT1, and GSTP1 genotypes by self-reported chemical-related sensitivity score (?

Positive_regulation (shows) of Gene_expression (distribution) of GSTM1

1) Confidence 0.50 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.18 Pain Relevance 0

Peripheral inflammation leads to an increase in mu receptor present on the peripheral terminals of primary sensory neurons.

Positive_regulation (increase) of Gene_expression (present) of mu in primary sensory neurons associated with inflammation

2) Confidence 0.10 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15054116 Disease Relevance 0.21 Pain Relevance 0.41

The mu rhythm results from the spontaneous firing of the sensorimotor neurons in synchrony around the ?

Positive_regulation (results) of Gene_expression (rhythm) of mu in neurons

3) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2361218 Disease Relevance 0 Pain Relevance 0.17

Inter-strain variation in GTM profiles

Positive_regulation (variation) of Gene_expression (profiles) of GTM associated with sprains and strains

4) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2798964 Disease Relevance 0.92 Pain Relevance 0

General Comments

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