INT117687

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.63
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSD1) extracellular region (TPSD1)
Anatomy Link Frequency
lamina 1
mast cells 1
TPSD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 25 99.34 Very High Very High Very High
Inflammatory response 2 88.28 High High
tetrodotoxin 1 84.72 Quite High
substance P 17 81.76 Quite High
cINOD 2 78.72 Quite High
Inflammation 115 78.52 Quite High
pruritus 1 73.84 Quite High
Pain 4 59.76 Quite High
Inflammatory mediators 3 54.96 Quite High
cytokine 9 28.80 Quite Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 96 99.48 Very High Very High Very High
Disease 36 99.34 Very High Very High Very High
Clostridium Difficile Infection 2 89.28 High High
Systemic Mastocytosis 5 88.80 High High
INFLAMMATION 114 87.92 High High
Hyperplasia 4 82.12 Quite High
Mastocytosis 5 79.20 Quite High
Cutaneous Mastocytosis 5 77.56 Quite High
Pruritus 1 73.84 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

9 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A specific inhibitor of aminopeptidase, amastatin, had no effect on anti-IgE induced tryptase and histamine release and was used as control.
Positive_regulation (induced) of tryptase
1) Confidence 0.44 Published 2004 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 15783133 Disease Relevance 0 Pain Relevance 0.08
A similar degree of inhibition of calcium ionophore A23187 (CI) induced tryptase release was also observed with these two inhibitors.
Positive_regulation (induced) of tryptase
2) Confidence 0.44 Published 2004 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 15783133 Disease Relevance 0 Pain Relevance 0
RESULTS: When tryptase was added to the basolateral (not mucosal) side of normal rectal biopsy tissues, permeability appeared to be proportional to the increase in tryptase concentration (P < 0.05) and was abolished by the addition of tryptase inhibitor (100 ?
Positive_regulation (increase) of tryptase
3) Confidence 0.16 Published 2010 Journal Dig. Dis. Sci. Section Body Doc Link 20087660 Disease Relevance 0 Pain Relevance 0
In the colorectal mucosa from patients with CD and UC, the amount of mast cell tryptase is significantly increased as is the number of mast cells in the lamina propria and submucosa [65].
Positive_regulation (increased) of tryptase in lamina associated with inflammatory bowel disease and crohn's disease
4) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2909178 Disease Relevance 1.04 Pain Relevance 0.29
Four minor criteria include the presence of elevated serum alpha-tryptase levels > 20 ng/mL, the expression of CD2 and CD25 surface markers in c-kit-positive mast cells from bone marrow or other organs, the presence of a c-kit mutations on bone marrow and/or other tissues mast cells, and the presence of > 25% abnormal spindle-shaped mast cells in bone marrow and/or tissues.
Positive_regulation (elevated) of alpha-tryptase in mast cells
5) Confidence 0.00 Published 2004 Journal Allergy Asthma Proc Section Abstract Doc Link 15055560 Disease Relevance 1.52 Pain Relevance 0.10

General Comments

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