INT11769

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Context Info
Confidence 0.60
First Reported 1985
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 6.38
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuroblast 1
MPTP 1
Mptp1 (Mus musculus)
Pain Link Frequency Relevance Heat
monoamine 8 100.00 Very High Very High Very High
Paracetamol 1 100.00 Very High Very High Very High
Dopamine 21 99.84 Very High Very High Very High
Morphine 43 99.58 Very High Very High Very High
fluoxetine 2 99.02 Very High Very High Very High
Desipramine 2 98.40 Very High Very High Very High
Neuropeptide 2 98.20 Very High Very High Very High
Enkephalin 11 97.92 Very High Very High Very High
tail-flick 2 95.24 Very High Very High Very High
opioid receptor 4 82.48 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 92 100.00 Very High Very High Very High
Apoptosis 13 100.00 Very High Very High Very High
Toxicity 10 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 7 100.00 Very High Very High Very High
Disease 110 97.40 Very High Very High Very High
Nociception 5 93.24 High High
Body Weight 1 91.28 High High
Death 9 84.76 Quite High
Hyperalgesia 1 79.12 Quite High
Cv Unclassified Under Development 23 78.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vice versa, inhibition of the mKCa channel with paxilline did not block protection induced by inhibition of the mPTP with cyclosporine A (CsA).8 Whether cardiac preconditioning by morphine is also mediated by regulation of the mPTP due to mKCa channel activation is yet unknown.
Spec (Whether) Regulation (regulation) of mPTP associated with morphine
1) Confidence 0.60 Published 2010 Journal Can J Anaesth Section Body Doc Link PMC2899019 Disease Relevance 0.08 Pain Relevance 0.43
MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters.
Neg (not) Regulation (regulated) of MPTP in neuroblast associated with parkinson's disease, dopamine, apoptosis and monoamine
2) Confidence 0.36 Published 2009 Journal Neurotoxicology Section Title Doc Link 19616025 Disease Relevance 0.99 Pain Relevance 0.35
Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP.
Neg (no) Regulation (effect) of MPTP associated with parkinson's disease, desipramine, drug induced neurotoxicity and fluoxetine
3) Confidence 0.24 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3876943 Disease Relevance 0.63 Pain Relevance 0.22
No significant effects of MPTP were found in the increasing temperature hot plate test.
Neg (No) Regulation (effects) of MPTP associated with parkinson's disease
4) Confidence 0.24 Published 1992 Journal Pharmacol. Toxicol. Section Abstract Doc Link 1594532 Disease Relevance 0.99 Pain Relevance 0.26
The aim of this study was to evaluate the effect of MPTP (2 x 45 mg/kg s.c., 20 h apart) on striatal neuropeptide Y-like immunoreactivity (NPY-LI) in C57BL/6 mice.
Regulation (effect) of MPTP associated with parkinson's disease and neuropeptide
5) Confidence 0.23 Published 2003 Journal J Neural Transm Section Abstract Doc Link 14666410 Disease Relevance 0.44 Pain Relevance 0.30
[Effects of monoamine oxidase B inhibitor and MPTP (1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine) on enkephalin levels in mice].
Regulation (Effects) of MPTP associated with parkinson's disease, enkephalin and monoamine
6) Confidence 0.17 Published 1990 Journal Zhonghua Shen Jing Jing Shen Ke Za Zhi Section Title Doc Link 2118063 Disease Relevance 0.53 Pain Relevance 0.96
This recovery potential in young mice allows for modeling of recovery [84].Various techniques can be used to modulate the action of MPTP to induce the pathological findings needed to reach the desired PD model.
Regulation (modulate) of MPTP associated with parkinson's disease and disease
7) Confidence 0.09 Published 2010 Journal Neurology Research International Section Body Doc Link PMC2989867 Disease Relevance 1.49 Pain Relevance 0.06
Experimental evidence point to peroxynitrite participation in the toxicity of doxorubicin, paraquat, acetaminophen and MPTP (N-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine).
Regulation (participation) of MPTP associated with parkinson's disease, toxicity and paracetamol
8) Confidence 0.02 Published 2005 Journal Toxicology Section Abstract Doc Link 15691591 Disease Relevance 0.60 Pain Relevance 0.10
These results suggest that the neuroprotective properties of CsA are mediated through modulation of the MPTP and maintenance of mitochondria homeostasis.
Regulation (modulation) of MPTP in MPTP associated with parkinson's disease
9) Confidence 0.01 Published 1999 Journal Exp. Neurol. Section Abstract Doc Link 10630207 Disease Relevance 0.63 Pain Relevance 0

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