INT1177

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 6.11
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
plasma 28
ventricle 2
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 2 99.48 Very High Very High Very High
anesthesia 25 99.42 Very High Very High Very High
Serotonin 8 99.10 Very High Very High Very High
Versed 2 99.02 Very High Very High Very High
ischemia 9 98.30 Very High Very High Very High
Dopamine 2 97.64 Very High Very High Very High
beta blocker 2 97.36 Very High Very High Very High
halothane 8 96.78 Very High Very High Very High
Pain 2 85.92 High High
opiate 1 82.40 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 92 100.00 Very High Very High Very High
Stress 11 100.00 Very High Very High Very High
Hemorrhage 6 99.90 Very High Very High Very High
Hypotension 3 99.72 Very High Very High Very High
Renal Failure 3 99.62 Very High Very High Very High
Stroke 9 98.76 Very High Very High Very High
Heart Rate Under Development 10 98.60 Very High Very High Very High
Hypertension 26 98.44 Very High Very High Very High
Coronary Artery Disease 9 98.30 Very High Very High Very High
Natriuresis 3 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of renin in normal plasma could also be induced at pH 7.4 by the addition of plasma from nephrectomized rats which had previously been dialyzed to pH 3.3.
Positive_regulation (induced) of Positive_regulation (Activation) of renin in plasma
1) Confidence 0.70 Published 1981 Journal Endocrinology Section Abstract Doc Link 7007027 Disease Relevance 0.06 Pain Relevance 0.15
These results indicate that the activation of renin by acid dialysis is not directly mediated by acid conditions and confirm the existence of an endogenous plasma factor which, after acid dialysis, is capable of converting inactive to active renin.
Neg (not) Positive_regulation (mediated) of Positive_regulation (activation) of renin in plasma
2) Confidence 0.70 Published 1981 Journal Endocrinology Section Abstract Doc Link 7007027 Disease Relevance 0 Pain Relevance 0.05
Prazosine induces only a slight increase plasma renin activity.
Positive_regulation (induces) of Positive_regulation (increase) of renin in plasma
3) Confidence 0.68 Published 1978 Journal Nouv Presse Med Section Abstract Doc Link 370766 Disease Relevance 0.43 Pain Relevance 0.10
The administration of the antianxiety drugs chlordiazepoxide (10 mg/kg i.p.) or midazolam (0.125-2 mg/kg i.p.) blocked the stress-induced increase in prolactin levels but not the stress-induced rise in plasma renin activity.
Positive_regulation (increase) of Positive_regulation (rise) of plasma renin in plasma associated with stress and versed
4) Confidence 0.48 Published 1985 Journal Brain Res. Section Abstract Doc Link 2994844 Disease Relevance 0.99 Pain Relevance 0.30
Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection.
Positive_regulation (increase) of Positive_regulation (induced) of renin in plasma associated with serotonin and fluoxetine
5) Confidence 0.47 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.29
Pretreatment with either of the blockers of serotonin uptake, fluoxetine or indalpine blocked the increase in plasma renin activity induced by fenfluramine at 30 min, but did not affect the decrease at 4 hr after injection.
Positive_regulation (induced) of Positive_regulation (increase) of renin in plasma associated with serotonin and fluoxetine
6) Confidence 0.47 Published 1985 Journal Neuropharmacology Section Abstract Doc Link 3160963 Disease Relevance 0 Pain Relevance 0.29
After 10 min of immobilization, plasma renin activity was increased and VIP in plasma was unchanged.
Positive_regulation (After) of Positive_regulation (increased) of plasma renin in plasma
7) Confidence 0.47 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.17
In anaesthetized rats, SQ 20.88) has an additional hypotensive effect which augments the increase in plasma renin.
Positive_regulation (augments) of Positive_regulation (increase) of plasma renin in plasma associated with hypotension
8) Confidence 0.41 Published 1975 Journal Acta Pathol Microbiol Scand A Section Abstract Doc Link 170788 Disease Relevance 0.49 Pain Relevance 0
After 30 min of tilting, plasma renin activity was also increased and VIP in plasma was unchanged.
Positive_regulation (After) of Positive_regulation (increased) of plasma renin in plasma
9) Confidence 0.41 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3072488 Disease Relevance 0 Pain Relevance 0.23
PGI2 induced an increase of plasma renin activity in anaesthetized rats with doses of 0.1, 1.0 and 10.0 micrograms/kg.
Positive_regulation (induced) of Positive_regulation (increase) of plasma renin in plasma
10) Confidence 0.34 Published 1978 Journal Prostaglandins Med Section Abstract Doc Link 364507 Disease Relevance 0.34 Pain Relevance 0
Spironolactone induced a significant reduction of plasma volume (42.1 +/- 5.5 to 36.1 +/- 6.6 mL/kg body weight, P < .01) and of the concentration of alpha-atrial natriuretic peptide (alpha-ANP) (39.8 +/- 22 to 27.7 +/- 20 pg/mL, P < .01); in addition, a pronounced increase in plasma renin activity (PRA) (1.1 +/- 0.9 to 7.5 +/- 3.4 ng/mL/h, P < .001) was induced by the treatment.
Positive_regulation (induced) of Positive_regulation (increase) of renin in plasma associated with natriuresis and body weight
11) Confidence 0.17 Published 1996 Journal Hepatology Section Abstract Doc Link 8621132 Disease Relevance 0.48 Pain Relevance 0.12
Halothane plus nitrous oxide produced an increase in plasma renin activity, which then subsided to normal by 210 minutes following anesthesia; breathing room air did not result in increases in plasma renin activity.
Neg (not) Positive_regulation (result) of Positive_regulation (increases) of renin in plasma associated with anesthesia and halothane
12) Confidence 0.10 Published 1979 Journal Lab. Anim. Sci. Section Abstract Doc Link 459413 Disease Relevance 0.09 Pain Relevance 0.98
Acute hypertension can result in an increase in afterload to the left ventricle, which may cause a reduction in the stroke volume, an elevation in the left ventricular filling pressure, and pulmonary congestion.13 The risk of myocardial ischemia, heart failure, stroke, neurocognitive dysfunction, renal failure, and bleeding are increased in patients with perioperative hypertension.14 In addition, adrenergic stimulation (occurring before, during, and after the operation) and activation of stress hormones and the renin┬ľangiotensin system in both previously hypertensive and nonhypertensive patients may increase the risk of postoperative crises.8

Acute management of hypertensive emergencies and urgencies

Positive_regulation (increased) of Positive_regulation (activation) of renin in ventricle associated with stress, heart rate under development, pressure and volume under development, coronary artery disease, renal failure, stroke, ischemia, hemorrhage, emergencies and hypertension
13) Confidence 0.08 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922306 Disease Relevance 2.38 Pain Relevance 0.05
Compared with control subjects, on admission patients showed increased plasma levels of ANP, as well as increased plasma renin activity (PRA), aldosterone, norepinephrine, epinephrine, dopamine, and antidiuretic hormone (ADH).
Positive_regulation (increased) of Positive_regulation (increased) of renin in plasma associated with dopamine
14) Confidence 0.07 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1829681 Disease Relevance 0.77 Pain Relevance 0.19
Activation of the renin-angiotensin system (RAS) or administration of angiotensin II (AII) will induce water intake.
Positive_regulation (induce) of Positive_regulation (Activation) of renin-angiotensin system
15) Confidence 0.06 Published 1980 Journal Am. J. Physiol. Section Abstract Doc Link 7377376 Disease Relevance 0 Pain Relevance 0
Captopril antihypertensive effect and captopril-induced plasma renin increase were almost totally abolished by a short-term administration of indomethacin (50 mg t.i.d.).
Positive_regulation (captopril-induced) of Positive_regulation (increase) of renin in plasma
16) Confidence 0.04 Published 1984 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6432714 Disease Relevance 0.10 Pain Relevance 0.08

General Comments

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