INT11770

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Context Info
Confidence 0.48
First Reported 1989
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 3.57
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
pituitary 1
Autonomic 1
anterior pituitary 1
Lhb (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 99.74 Very High Very High Very High
agonist 15 98.40 Very High Very High Very High
narcan 6 98.24 Very High Very High Very High
Kinase C 272 96.72 Very High Very High Very High
Pain 1 85.52 High High
Serotonin 4 78.80 Quite High
Dopamine 2 76.56 Quite High
tail-flick 1 76.32 Quite High
Inflammation 7 76.16 Quite High
analgesia 1 75.04 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 24 99.60 Very High Very High Very High
Disease 64 99.04 Very High Very High Very High
Hypopituitarism 2 97.56 Very High Very High Very High
Glioma 1 94.04 High High
Brain Tumor 1 93.40 High High
Aging 20 92.64 High High
Renal Cancer 1 90.56 High High
Congenital Anomalies 6 86.44 High High
Pain 1 85.52 High High
Diuresis 1 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lymphocytic hypophysitis(LH) is a rare but increasingly recognized autoimmune endocrine condition that causes partial or total hypopituitarism and is often associated with peripartum young women.
LH Binding (recognized) of associated with hypopituitarism
1) Confidence 0.48 Published 2009 Journal Beijing Da Xue Xue Bao Section Abstract Doc Link 19377639 Disease Relevance 0.30 Pain Relevance 0.14
However, if LH pulses are eliminated by GnRH analogue, the frequency of flushing is not altered, which confirms that LH is merely associated with the flush rather than being causative.
LH Binding (associated) of associated with increased venous pressure under development
2) Confidence 0.42 Published 2008 Journal Maturitas Section Abstract Doc Link 18384981 Disease Relevance 0.76 Pain Relevance 0.22
A link with gonadotrophins is demonstrated by a temporal association of flushes with the pulsatile release of luteinising hormone (LH).
LH Binding (association) of
3) Confidence 0.42 Published 2008 Journal Maturitas Section Abstract Doc Link 18384981 Disease Relevance 0.93 Pain Relevance 0.20
Autonomic and limbic information is integrated within the lateral hypothalamus (LH), and excitability of LH neurons is important in the control of feeding and behavioral arousal.
LH Binding (excitability) of in Autonomic
4) Confidence 0.36 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12077176 Disease Relevance 0 Pain Relevance 0.15
Notably, one powerful endogenous mitogen, luteinizing hormone

(LH), a gonadotropin most often associated with reproduction, is

LH Binding (endogenous mitogen) of
5) Confidence 0.33 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559918 Disease Relevance 1.12 Pain Relevance 0.03
The results indicate that the behavioral effects of the LH-RH agonist can be antagonized by pretreatments with a potent LH-RH antagonist designed to block pituitary LH-RH receptors, with the exception of the suppression of apomorphine-induced cage-climbing, where special type of receptors and/or mechanisms might be involved.
LH-RH Neg (block) Binding (block) of in pituitary associated with antagonist and agonist
6) Confidence 0.22 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1594632 Disease Relevance 0 Pain Relevance 0.48
A rebound in LH and testosterone was seen about the 50th day after the microcapsule administration.
LH Binding (rebound) of
7) Confidence 0.19 Published 1989 Journal Prostate Section Abstract Doc Link 2526325 Disease Relevance 0.46 Pain Relevance 0.15
The association between GnRH and LH pulses during the follicular and luteal phases of the monkey menstrual cycle is less clearly defined.
LH Binding (association) of
8) Confidence 0.12 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8828858 Disease Relevance 0 Pain Relevance 0
mol in combination with LH, the values on P4 accumulation became intermediate between those observe for basal and LH alone (Fig. 6); and the stimulatory effect of LH was completely eliminated by 1000 ?
LH Binding (basal) of
9) Confidence 0.11 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0
mol in combination with LH, the values on P4 accumulation became intermediate between those observe for basal and LH alone (Fig. 6); and the stimulatory effect of LH was completely eliminated by 1000 ?
LH Binding (combination) of
10) Confidence 0.11 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0
Ovarian cycling, controlled by anterior pituitary follicle-stimulating hormone (FSH), luteinizing hormone (LH), and their hypothalamic releasing hormones, was identical in bIGF1RKO+/?
LH Binding (anterior) of in anterior pituitary
11) Confidence 0.11 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2573928 Disease Relevance 0 Pain Relevance 0
, or a combination of LH and PGF2?
LH Binding (combination) of
12) Confidence 0.09 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.16
(1000 ng/ml), or a combination of LH and PGF2?
LH Binding (combination) of
13) Confidence 0.09 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2041951 Disease Relevance 0 Pain Relevance 0.12
There was a significant period x day interaction for LH (p < 0.03) and PRL (p < 0.015).
LH Binding (interaction) of
14) Confidence 0.09 Published 1996 Journal Biol. Reprod. Section Abstract Doc Link 8828835 Disease Relevance 0 Pain Relevance 0.27

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