INT11771

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Context Info
Confidence 0.38
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.98
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Mbp) nucleus (Mbp) cytoplasm (Mbp)
Anatomy Link Frequency
perirhinal cortex 1
filaments 1
spinal cord 1
oligodendrocyte 1
Mbp (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 32 99.98 Very High Very High Very High
Spinal cord 23 97.70 Very High Very High Very High
Multiple sclerosis 140 93.92 High High
Demyelination 25 91.72 High High
imagery 27 86.80 High High
Neuritis 11 86.76 High High
cytokine 24 82.72 Quite High
chemokine 5 81.36 Quite High
Central nervous system 36 80.64 Quite High
Inflammation 49 67.04 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 320 98.28 Very High Very High Very High
General Immunology 1 95.20 Very High Very High Very High
Demyelinating Disease 31 91.72 High High
Transverse Myelitis 3 90.96 High High
Optic Neuritis 10 86.76 High High
Adhesions 5 80.40 Quite High
Neurodegenerative Disease 19 69.76 Quite High
Urological Neuroanatomy 3 67.52 Quite High
INFLAMMATION 52 67.04 Quite High
Disease 125 57.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(25–35)-injected mice receiving vehicle, and administration of Kihi-to resulted in an increase in MBP expression levels in the perirhinal cortex (Figures 6 and 7).


Positive_regulation (increase) of MBP in perirhinal cortex
1) Confidence 0.38 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.07 Pain Relevance 0
Immunologic studies focused on myelin protein specific immune responses including those directed against myelin basic protein (MBP), proteolipid protein (PLP) and myelin oligodendrocyte protein (MOG).
Positive_regulation (directed) of myelin basic protein in oligodendrocyte
2) Confidence 0.35 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.62 Pain Relevance 0.51
The cultures were co-stained for MBP and PGP9.5 and nuclei were visualized with DAPI (4?
Positive_regulation (stained) of MBP
3) Confidence 0.24 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.09 Pain Relevance 0.09
Recombinant MBP-tomosyn was incubated with syntaxin-1 lacking the transmembrane domain (referred to as syntaxin-1 hereafter), SNAP-25, and VAMP-2 lacking the transmembrane (referred to as VAMP-2 hereafter) for 12 h under reducing conditions.
Positive_regulation (incubated) of Recombinant MBP-tomosyn
4) Confidence 0.21 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
In the present study, we demonstrate that Olig1 deficiency, or reduced expression of MOG, MBP and MAG caused by Olig1 deficiency, delayed the onset of EAE.
Positive_regulation (caused) of MBP associated with multiple sclerosis
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947525 Disease Relevance 0.87 Pain Relevance 0.29
Our observations show the variability of spinal cord deficit and the fact that there can be a good prognosis, despite severe initial neurological deficits and massive elevation of basic myelin protein in children with ATM.
Positive_regulation (elevation) of basic myelin protein in spinal cord associated with spinal cord
6) Confidence 0.07 Published 1992 Journal Schweiz. Rundsch. Med. Prax. Section Abstract Doc Link 1594852 Disease Relevance 0.34 Pain Relevance 0.14
Moreover, in a manner similar to the effects of leptin in this study, the structural dendritic changes induced by integrins occur rapidly (within 30 min), involve reorganization of actin filaments and require NMDA receptor activation (Shi and Ethell, 2006).
Positive_regulation (activation) of Shi in filaments associated with nmda receptor
7) Confidence 0.04 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.08

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