INT117714

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.44
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
caudate putamen 3
bone marrow 2
nucleus accumbens 1
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 8 99.68 Very High Very High Very High
opioid receptor 133 98.68 Very High Very High Very High
Morphine 25 97.04 Very High Very High Very High
Serotonin 2 75.00 Quite High
antagonist 37 73.48 Quite High
fluoxetine 2 67.48 Quite High
agonist 13 54.84 Quite High
analgesia 20 50.00 Quite Low
Visceral pain 15 40.80 Quite Low
Opioid 14 36.48 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerosis 35 97.96 Very High Very High Very High
Stress 9 91.44 High High
Diabetes Mellitus 45 86.80 High High
Cardiovascular Disease 7 50.00 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

15 40.80 Quite Low
Brain Hemorrhage 2 35.48 Quite Low
Aging 1 26.72 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

32 5.00 Very Low Very Low Very Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examined the regulation of ERK and Akt activation in the nucleus accumbens and caudate putamen following acute and chronic morphine administration in the rat.
Spec (examined) Regulation (regulation) of Spec (examined) Positive_regulation (activation) of Akt in caudate putamen associated with nucleus accumbens and morphine
1) Confidence 0.61 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.53
We next studied whether glucose-stimulated Akt is involved in OGG1 downregulation.
Spec (whether) Regulation (involved) of Spec (whether) Positive_regulation (stimulated) of Akt
2) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
Transamidation of RhoA leads to RhoA activation and enhanced proteasomal degradation, which in turn is responsible for Akt activation and contraction inhibition.
Regulation (responsible) of Positive_regulation (activation) of Akt
3) Confidence 0.31 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.16
These findings are consistent with the observation that activation and internalization of a GPCR can be regulated by activation of the PI3K/AKT pathway [43].
Regulation (regulated) of Positive_regulation (activation) of AKT
4) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.39
This effect seems to involve the stimulation of PI3K-Akt in the bone marrow, which improves microvessel function and subsequent EPC release (Dimmeler et al 2001).
Spec (seems) Regulation (involve) of Positive_regulation (stimulation) of Akt in bone marrow
5) Confidence 0.26 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721378 Disease Relevance 0.26 Pain Relevance 0
Both in vivo and in vitro studies suggest that the increased Akt activity is involved in hyperpermeability of the BBB [16,17,23].
Regulation (involved) of Positive_regulation (increased) of Akt
6) Confidence 0.22 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.18 Pain Relevance 0
The present study examined the regulation of ERK and Akt activation in the nucleus accumbens and caudate putamen following acute and chronic morphine administration in the rat.
Spec (examined) Regulation (regulation) of in nucleus accumbens Spec (examined) Positive_regulation (activation) of Akt in caudate putamen associated with nucleus accumbens and morphine
7) Confidence 0.21 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.53

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