INT117715

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 3.23
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
myocardium 2
cardiomyocyte 2
muscle 2
hearts 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 69 100.00 Very High Very High Very High
imagery 19 99.60 Very High Very High Very High
fibrosis 14 99.58 Very High Very High Very High
Morphine 25 99.12 Very High Very High Very High
opioid receptor 133 98.00 Very High Very High Very High
ischemia 48 96.04 Very High Very High Very High
agonist 47 94.88 High High
antagonist 55 93.28 High High
Nucleus accumbens 8 86.84 High High
Enkephalin 6 86.28 High High
Disease Link Frequency Relevance Heat
Fibrosis 12 99.58 Very High Very High Very High
Aging 40 99.20 Very High Very High Very High
Apoptosis 76 99.06 Very High Very High Very High
Hypertrophy 15 98.84 Very High Very High Very High
Myocardial Infarction 90 98.16 Very High Very High Very High
Cv Unclassified Under Development 46 96.04 Very High Very High Very High
Diabetes Mellitus 284 92.48 High High
Coronary Heart Disease 13 82.80 Quite High
Obesity 5 69.00 Quite High
Frailty 5 67.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although alterations in Akt abundance and phosphorylation have been shown in aging muscle [5], [6], little is known about whether or not aging affects Akt kinase function.
Regulation (alterations) of Phosphorylation (phosphorylation) of Akt in muscle associated with aging
1) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.63 Pain Relevance 0.09
To confirm the validity of these data obtained in the MCT immortalized cells, we studied the effects of high glucose on the phosphorylation of Akt and tuberin and on OGG1 protein expression in RPTE cells.
Regulation (effects) of Phosphorylation (phosphorylation) of Akt
2) Confidence 0.51 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
To investigate the role of high glucose in Akt and tuberin phosphorylation, MCT cells were incubated for the indicated time periods in serum-free medium containing either normal glucose or high glucose.
Spec (investigate) Regulation (role) of Phosphorylation (phosphorylation) of Akt
3) Confidence 0.51 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.44 Pain Relevance 0
In vivo regulation of extracellular signal-regulated protein kinase (ERK) and protein kinase B (Akt) phosphorylation by acute and chronic morphine.
Regulation (regulation) of Phosphorylation (phosphorylation) of Akt associated with morphine
4) Confidence 0.45 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.72
In vivo regulation of extracellular signal-regulated protein kinase (ERK) and protein kinase B (Akt) phosphorylation by acute and chronic morphine.
Regulation (regulation) of Phosphorylation (phosphorylation) of protein kinase B associated with morphine
5) Confidence 0.45 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15056728 Disease Relevance 0 Pain Relevance 0.72
Collectively, our data indicate that ROS are signaling molecules responsible for Akt phosphorylation initiated by high glucose leading to tuberin phosphorylation and OGG1 protein downregulation.
Regulation (responsible) of Phosphorylation (phosphorylation) of Akt
6) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.17 Pain Relevance 0
These data demonstrate that phosphorylation of Akt and tuberin and downregulation of OGG1 are redox sensitive in MCT cells.


Regulation (sensitive) of Phosphorylation (phosphorylation) of Akt
7) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
The fact that oxidant-induced effects on Akt and tuberin phosphorylation correlate well with those of high glucose suggests that ROS may mediate the action of high glucose on Akt, tuberin, and OGG1.
Regulation (effects) of Phosphorylation (phosphorylation) of Akt
8) Confidence 0.37 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
Furthermore, in order to explore the potential of pre-ischemic effluent administrations ability to modulate Akt phosphorylation at reperfusion, a separate group for WB only were administered effluent for 10 min prior to index ischemia and the tissue harvested after these hearts had been reperfused for 15 min (EffPre+Rep).
Regulation (modulate) of Phosphorylation (phosphorylation) of Akt in hearts associated with ischemia
9) Confidence 0.36 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC3012213 Disease Relevance 0.10 Pain Relevance 0.05
Interestingly, while a trend towards a fall in phosphorylation of AKT residue Ser473 was observed, it failed to reach statistical significance (P?
Regulation (fall) of Phosphorylation (phosphorylation) of AKT
10) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Effect of H2S on AKT phosphorylation
Regulation (Effect) of Phosphorylation (phosphorylation) of AKT
11) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.48
In agreement with our imaging data (Fig. 3), the effect of dopamine administration on the phosphorylation of Akt was evident after 15 minutes (Fig.
Regulation (effect) of Phosphorylation (phosphorylation) of Akt associated with dopamine and imagery
12) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.05 Pain Relevance 0.59
In particular we wanted to investigate whether MI-induced cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis was associated with changes in Akt - FOXO3a phosphorylation, Sirt1 - p53 deacetylation and p38 MAPK phosphorylation.


Regulation (changes) of Phosphorylation (phosphorylation) of Akt in cardiomyocyte associated with fibrosis, hypertrophy, apoptosis and myocardial infarction
13) Confidence 0.22 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.49 Pain Relevance 0.12
However, LPS-induced endotoxaemia did not appear to have any significant effect on the phosphorylation state of residue Ser473 of AKT in the myocardium (Fig. 4B) nor on p70 S6K protein levels (Fig. 4C).
Regulation (effect) of Phosphorylation (phosphorylation) of AKT in myocardium
14) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
Furthermore, the absence of any effect on phosphorylation levels of other signaling kinases, including AKT, demonstrates that the effects of HN are independent of hypo thalamic insulin signaling.
Regulation (effect) of Phosphorylation (phosphorylation) of AKT
15) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709436 Disease Relevance 0.35 Pain Relevance 0
In contrast, B2 saponin extract increased Akt phosphorylation without affecting that of ERK1/2.
Neg (without) Regulation (affecting) of Phosphorylation (phosphorylation) of Akt
16) Confidence 0.04 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0 Pain Relevance 0

General Comments

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