INT117717

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.61
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 100.00 Very High Very High Very High
antagonist 8 99.74 Very High Very High Very High
ischemia 67 98.24 Very High Very High Very High
Nucleus accumbens 4 96.44 Very High Very High Very High
bDMF 24 91.28 High High
opioid receptor 1 69.44 Quite High
Opioid 1 59.36 Quite High
long-term potentiation 2 50.00 Quite Low
Anterior cingulate cortex 2 50.00 Quite Low
Hippocampus 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 59 98.24 Very High Very High Very High
Pain 1 65.24 Quite High
Cognitive Disorder 16 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Stroke 6 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Middle Cerebral Artery Infarction 3 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naltrexone pretreatment prevented both the morphine-induced pERK down-regulation and pAkt up-regulation.
Negative_regulation (prevented) of Regulation (regulation) of pERK associated with morphine
1) Confidence 0.41 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.21
The up-regulation in pERK and pCREB expressions could be blocked by pretreatment of PD98059.
Negative_regulation (blocked) of Regulation (regulation) of pERK
2) Confidence 0.30 Published 2009 Journal Neurosci Bull Section Body Doc Link 19784086 Disease Relevance 0.07 Pain Relevance 0
Furthermore, as shown in Fig. 6, additional work suggests that EDC and E2-BSA regulatory effects upon ERK, Akt and JNK activation after GCI are mediated by estrogen receptors, as pretreatment with the ER antagonist, ICI182,780 abolished EDC and E2-BSA modulation of ERK, Akt and JNK activation in the CA1 region at 10min reperfusion.


Negative_regulation (abolished) of Regulation (modulation) of ERK associated with antagonist and ischemia
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.55 Pain Relevance 0.41

General Comments

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