INT117718

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 112
Total Number 118
Disease Relevance 39.26
Pain Relevance 24.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
muscle 10
hearts 8
adipose tissue 8
brain 4
renal cortex 4
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 1712 100.00 Very High Very High Very High
qutenza 20 100.00 Very High Very High Very High
Nucleus accumbens 5 100.00 Very High Very High Very High
antagonist 526 99.80 Very High Very High Very High
Paracetamol 780 99.56 Very High Very High Very High
ischemia 554 99.56 Very High Very High Very High
dorsal root ganglion 13 99.52 Very High Very High Very High
Morphine 68 99.36 Very High Very High Very High
Dopamine 140 98.64 Very High Very High Very High
agonist 248 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1456 99.98 Very High Very High Very High
Myocardial Infarction 458 99.98 Very High Very High Very High
Hyperglycemia 254 99.98 Very High Very High Very High
Stroke 84 99.96 Very High Very High Very High
Bordatella Infection 2 99.92 Very High Very High Very High
Cv Unclassified Under Development 432 99.56 Very High Very High Very High
Aging 497 99.54 Very High Very High Very High
Ganglion Cysts 13 99.52 Very High Very High Very High
Stress 392 99.32 Very High Very High Very High
Insulin Resistance 156 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated Akt levels in the nucleus accumbens were significantly increased after a single morphine injection.
Positive_regulation (increased) of Phosphorylation (Phosphorylated) of Akt in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.12
Paradoxically, this increased Akt phosphorylation is associated with lower Akt kinase activity, diminished response to insulin, higher levels of myocyte apoptosis, lower abundance of contractile proteins myosin and actin, and a smaller muscle fiber cross-sectional area (atrophy).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt in muscle fiber associated with frailty and apoptosis
2) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.45 Pain Relevance 0.30
Paradoxically, these increases in Akt phosphorylation were associated with diminished mammalian target of rapamycin (mTOR) phosphorylation, along with decreased levels of insulin receptor beta (IR-?)
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Akt
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.24 Pain Relevance 0.17
Interestingly, this decrease in activity occurs even though the amount of Akt phosphorylation (Ser473 and Thr308) is actually increased in the aged muscle.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt in muscle
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.22 Pain Relevance 0.08
Using an ex vivo approach resulted in a similar conclusion as the aged control muscles required higher levels of Akt phosphorylation (both Ser474 and Thr308) to phosphorylate similar amounts of GSK3?
Positive_regulation (levels) of Phosphorylation (phosphorylation) of Akt in muscles
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.17 Pain Relevance 0.09
Additionally, we demonstrated that exposure of bilateral renal denervated or of renal chronic capsaicin-treated rats to a similar experimental protocol results in a fast and high rise in rectal temperature response, and this is associated with a significant increase in the basal serine phosphorylation and protein levels of Akt and protein levels of UCP1.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Akt
6) Confidence 0.59 Published 2008 Journal Nephrol. Dial. Transplant. Section Body Doc Link 18593740 Disease Relevance 0 Pain Relevance 0
High glucose caused a rapid increase in Akt and tuberin phosphorylation in a time-dependent manner, with effects that peaked at 2.5–5 min and subsided by 60 min (Fig. 3A and B).
Positive_regulation (caused) of Phosphorylation (phosphorylation) of Akt
7) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.35 Pain Relevance 0
High glucose induces Akt and tuberin phosphorylation, increases 8-oxodG, and downregulates OGG1 in MCT cells.
Positive_regulation (induces) of Phosphorylation (phosphorylation) of Akt
8) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.53 Pain Relevance 0
High glucose increases Akt and tuberin phosphorylation and downregulates OGG1 in primary proximal tubular epithelial cells.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Akt in epithelial cells
9) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
In a number of cells, high glucose promotes an increase in Akt phosphorylation (43,44).
Positive_regulation (promotes) of Phosphorylation (phosphorylation) of Akt
10) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.77 Pain Relevance 0
PI 3-kinase/Akt pathways mediate high glucose–induced Akt phosphorylation and OGG1 protein downregulation in MCT cells.
Positive_regulation (mediate) of Phosphorylation (phosphorylation) of Akt
11) Confidence 0.57 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0 Pain Relevance 0
The DADLE-dependent increases in Akt and ERK1/2 phosphorylation were abolished by either MPI or AG1478, confirming a signaling through the EGFR pathway.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of Akt
12) Confidence 0.55 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.27 Pain Relevance 0.41
In rabbit, this protection leads to phosphorylation of the pro-survival kinases Akt and extracellular signal-regulated kinase (ERK) and is dependent on transactivation of the epidermal growth factor receptor (EGFR).
Positive_regulation (leads) of Phosphorylation (phosphorylation) of Akt
13) Confidence 0.55 Published 2007 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 17545478 Disease Relevance 0.27 Pain Relevance 0.38
The increased phosphorylation of Akt and GSK3?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt
14) Confidence 0.55 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
However, increased phosphorylation of Akt is also evident 24 hours after sonication, the time window that the tight junction proteins are re-assembled and the BBB function is restored.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt
15) Confidence 0.55 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.22 Pain Relevance 0.03
Ultrasound-mediated disruption of the BBB is associated with increased phosphorylation of Akt and its downstream signaling molecule GSK3?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt
16) Confidence 0.55 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
We show that phosphorylation of Akt at both serine (S473) and threonine (T308) residues is increased in the sonicated brain, while the total Akt protein level remains unchanged (Figure 4A).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Akt in brain
17) Confidence 0.55 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
PI3K/Akt inhibitor LY294002 blocked roflumilast-induced Akt phosphorylation and protective effect.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Akt
18) Confidence 0.51 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18276108 Disease Relevance 0.55 Pain Relevance 0.03
Capsaicin also markedly induced the phosphorylation of Akt.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Akt associated with qutenza
19) Confidence 0.50 Published 2008 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 19011674 Disease Relevance 0.73 Pain Relevance 0.59
Our data confirm these observations and show an early and sustained increase in Akt phosphorylation after exposure of the cells to high glucose.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Akt
20) Confidence 0.50 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.65 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox