INT117719

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) plasma membrane (Ephb1)
cytoplasm (Ephb1)
Anatomy Link Frequency
neurons 1
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 11 99.02 Very High Very High Very High
Nucleus accumbens 4 92.40 High High
Opioid 1 70.08 Quite High
Glutamate receptor 1 61.60 Quite High
opioid receptor 1 61.36 Quite High
gABA 3 58.00 Quite High
long-term potentiation 7 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 55.68 Quite High
Amnesia 4 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although reductions in pERK levels were evident after 6 days of morphine administration, no differences were observed in pERK levels after 10 days.
Transcription (levels) of pERK associated with morphine
1) Confidence 0.44 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.19
Kozinn and co-workers demonstrated that lower concentrations of propofol inhibits N-methyl-D-aspartate (NMDA) receptor activation of MAPK/ERK pathway and c-Fos transcription in hippocampal neurons[14].
Transcription (transcription) of ERK in neurons
2) Confidence 0.09 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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