INT117720

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 2.33
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
neurons 4
nucleus accumbens 2
neurite 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 5 100.00 Very High Very High Very High
Morphine 11 99.96 Very High Very High Very High
Dopamine 241 99.68 Very High Very High Very High
antagonist 36 97.72 Very High Very High Very High
agonist 63 97.08 Very High Very High Very High
cva 24 96.66 Very High Very High Very High
imagery 40 96.48 Very High Very High Very High
Inflammatory response 3 91.24 High High
Nerve growth factor 17 90.80 High High
Inflammation 19 81.76 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 17 99.78 Very High Very High Very High
Lactic Acidosis 1 98.40 Very High Very High Very High
Hypothermia 138 97.34 Very High Very High Very High
Hemorrhage 46 96.66 Very High Very High Very High
INFLAMMATION 25 90.88 High High
Vascular System Injuries 4 90.08 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 38 88.48 High High
Cv General 2 Under Development 18 85.36 High High
Reprotox - General 1 3 80.40 Quite High
Postoperative Complications 1 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the up-regulation seen after acute morphine, pAkt levels in the nucleus accumbens were significantly decreased after chronic morphine administration.
Negative_regulation (decreased) of Gene_expression (levels) of pAkt in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.37 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.21
In vitro studies suggest that hypoinsulinemia may regulate the actions of AMPH by inhibiting the insulin downstream effectors phosphotidylinositol 3-kinase (PI3K) and protein kinase B (PKB, or Akt), which we have previously shown are able to fine-tune DAT cell-surface expression.
Negative_regulation (inhibiting) of Gene_expression (expression) of protein kinase B
2) Confidence 0.35 Published 2007 Journal PLoS Biology Section Abstract Doc Link PMC2020502 Disease Relevance 0 Pain Relevance 0.27
An overall decrease in COX-2, EGFR, Akt, androgen receptor, and cyclin D1 expression was found associated with tumor growth inhibition.
Negative_regulation (decrease) of Gene_expression (expression) of Akt
3) Confidence 0.32 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.06 Pain Relevance 0
A strong inhibition of total and phosphorylated form of EGFR (Tyr(992) and Tyr(845)) and Akt (Ser(473)) was significant in rats given with these agents in combination.
Negative_regulation (inhibition) of Gene_expression (form) of Akt
4) Confidence 0.31 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.05 Pain Relevance 0
Immunohistochemical and Western blot analysis were done to determine COX-2, epidermal growth factor receptor (EGFR), Akt, androgen receptor, and cyclin D1 expression.
Spec (determine) Negative_regulation (determine) of Gene_expression (expression) of Akt
5) Confidence 0.31 Published 2007 Journal Clin. Cancer Res. Section Body Doc Link 17908994 Disease Relevance 0.08 Pain Relevance 0
These data indicate the levels of phospho-Akt are elevated in neurons with overexpressed NCS1 and blockade of Akt production reduces neurite sprouting in these neurons.
Negative_regulation (blockade) of Gene_expression (production) of Akt in neurite
6) Confidence 0.28 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.09 Pain Relevance 0
0.092) towards reduced phosphorylation of AKT residue Ser473 was detected (Fig. 4B). 24 h LPS infusion had no effect on the protein level or phosphorylation state of residues Thr421 and Ser424 of p70 S6K (Fig. 4C & 4D), nor on the phosphorylation state of Thr37 and Thr46 of 4E-BP1 (Fig. 4E), where both p70 S6K and 4E-BP1 are located downstream of AKT.
Negative_regulation (reduced) of Gene_expression (residue) of AKT
7) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0.03
A potent and specific inhibitor of Akt (AKTi-1/2; naphthyridinone) and the Gsk3?
Negative_regulation (inhibitor) of Gene_expression (naphthyridinone) of Akt
8) Confidence 0.23 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.06 Pain Relevance 0.16
When neurons were treated with dopamine alone (30 nM), levels of activated Akt (pAkt) decreased by 50% (Fig. 7A, B).
Negative_regulation (decreased) of Gene_expression (levels) of Akt in neurons associated with dopamine
9) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.06 Pain Relevance 0.59
When neurons were treated with dopamine alone (30 nM), levels of activated Akt (pAkt) decreased by 50% (Fig. 7A, B).
Negative_regulation (decreased) of Gene_expression (levels) of pAkt in neurons associated with dopamine
10) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0.06 Pain Relevance 0.59
In a small animal model of lethal hemorrhage treated with profound hypothermia, our team has demonstrated decreased lactic acidosis and improved survival along with a significant decrease in apoptotic proteins, preserved phosphorylated Akt levels, and increased prosurvival intermediates such as Bcl-2 and ?
Negative_regulation (preserved) of Gene_expression (levels) of Akt associated with hypothermia, lactic acidosis, cva and apoptosis
11) Confidence 0.09 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 1.87 Pain Relevance 0.24
1 completely abolished ERK1/2 response and diminished that of Akt after either 6 or 21 h incubation (Fig. 2C and D).
Negative_regulation (abolished) of Gene_expression (response) of Akt
12) Confidence 0.03 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0 Pain Relevance 0

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