INT117721

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 6.26
Pain Relevance 6.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
dorsal horn 10
neurons 4
neuronal 2
myocardium 2
nucleus accumbens 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn 19 100.00 Very High Very High Very High
Nucleus accumbens 4 100.00 Very High Very High Very High
Hippocampus 3 99.52 Very High Very High Very High
Morphine 12 99.36 Very High Very High Very High
agonist 101 99.26 Very High Very High Very High
spinal dorsal horn 6 99.24 Very High Very High Very High
nMDA receptor 8 99.12 Very High Very High Very High
antagonist 56 98.10 Very High Very High Very High
depression 8 97.76 Very High Very High Very High
nociceptor 6 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 8 97.76 Very High Very High Very High
Neuroblastoma 6 96.88 Very High Very High Very High
Urological Neuroanatomy 5 96.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 39 96.36 Very High Very High Very High
Diabetes Mellitus 142 96.32 Very High Very High Very High
INFLAMMATION 6 95.76 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 95.44 Very High Very High Very High
Nociception 26 94.92 High High
Obesity 2 94.72 High High
Hypertrophy 1 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylated Akt levels in the nucleus accumbens were significantly increased after a single morphine injection.
Positive_regulation (increased) of Gene_expression (levels) of Akt in nucleus accumbens associated with nucleus accumbens and morphine
1) Confidence 0.69 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15056728 Disease Relevance 0 Pain Relevance 1.12
In this study, we show that in naive animals almost all cells express Akt but only a subset of small-diameter neurons expresses a high level of phospho-Akt (p-Akt Ser 473).
Positive_regulation (level) of Gene_expression (expresses) of Akt in neurons
2) Confidence 0.49 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869474 Disease Relevance 0.48 Pain Relevance 0.51
Moreover, levels of Akt and phospho-Akt in all experimental groups remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (levels) of Akt
3) Confidence 0.46 Published 2009 Journal Pharmacol Rep Section Abstract Doc Link 19815943 Disease Relevance 0.82 Pain Relevance 0.46
Meanwhile, L5 SNL also induced an increased expression of p-PKB/Akt in ipsilateral L5 spinal dorsal horn.
Positive_regulation (increased) of Gene_expression (expression) of Akt in dorsal horn associated with spinal dorsal horn
4) Confidence 0.46 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17628541 Disease Relevance 0.57 Pain Relevance 0.85
In this study, we show that in naive animals almost all cells express Akt but only a subset of small-diameter neurons expresses a high level of phospho-Akt (p-Akt Ser 473).
Positive_regulation (level) of Gene_expression (expresses) of p-Akt Ser 473 in neurons
5) Confidence 0.43 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869474 Disease Relevance 0.48 Pain Relevance 0.51
The concept that the PI 3-kinase/Akt pathway regulates tuberin is supported by other observations that the expression of a constitutively active PI 3-kinase or active Akt, including Akt1 or Akt2, induce tuberin phosphorylation (27).
Positive_regulation (induce) of Gene_expression (expression) of Akt1
6) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.32 Pain Relevance 0
The concept that the PI 3-kinase/Akt pathway regulates tuberin is supported by other observations that the expression of a constitutively active PI 3-kinase or active Akt, including Akt1 or Akt2, induce tuberin phosphorylation (27).
Positive_regulation (induce) of Gene_expression (expression) of Akt
7) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.32 Pain Relevance 0
Focused ultrasound treatment in the presence of ultrasound contrast agent, increases PI3 kinase/Akt signaling activity, while the activity of MAPK signaling pathways remains unaffected
Positive_regulation (increases) of Gene_expression (/) of Akt
8) Confidence 0.40 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
It can be envisioned from these results that Akt-mediated downregulation of these genes of neuronal function is relevant to the diminished manifestation of neuronal phenotype in cells overexpressing Akt.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Akt in neuronal
9) Confidence 0.38 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0.35 Pain Relevance 0.03
As stated above, our experiments were based on two Akt-manipulated PC12 sublines that turned out to have quite different neurite outgrowth phenotypes from each other; cells overexpressing Akt do not differentiate well but the other cells that express the dominant-negative form of Akt make neurites quite well.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Akt in neurites
10) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2844376 Disease Relevance 0 Pain Relevance 0
Activities of a number of kinases can be modulated by PP2A both in vitro and in vivo, particularly the ERK/MAPKs, the calmodulin-dependent kinases, PKA PKB, PKC, p70S6 kinase, the I?
Positive_regulation (particularly) of Gene_expression (/) of PKB
11) Confidence 0.26 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0.23 Pain Relevance 0.11
Apropos of this fact, a plausible link between cAMP and Akt might be PP2A, a phosphatase which can be activated by PKA and is responsible for the dephosphorylation of Akt [10], [37].
Positive_regulation (activated) of Gene_expression (Apropos) of Akt
12) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.03
To explore this possibility, we performed experiments in which 5-HT and dopamine receptor agonists and antagonists were added sequentially in different combinations to the same culture and their cumulative effects on mitochondrial movements were observed over time using time-lapse fluorescence microscopy (Figs. 9A, C) and by Western blot analysis to detect activated Akt levels under the same conditions (Figs. 9B, D).
Positive_regulation (activated) of Gene_expression (levels) of Akt associated with antagonist, dopamine receptor and agonist
13) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.51
When compared with vehicle solution, intracolonic mustard oil sensitized the NMDA receptor NR2B subunit-dependent reflex activity and increased expression levels of phosphorylated Akt (pAkt) and phosphorylated NR2B (pNR2B) in dorsal horn.
Positive_regulation (increased) of Gene_expression (expression) of phosphorylated Akt in dorsal horn associated with nmda receptor and dorsal horn
14) Confidence 0.23 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20067569 Disease Relevance 0.25 Pain Relevance 0.26
When compared with vehicle solution, intracolonic mustard oil sensitized the NMDA receptor NR2B subunit-dependent reflex activity and increased expression levels of phosphorylated Akt (pAkt) and phosphorylated NR2B (pNR2B) in dorsal horn.
Positive_regulation (increased) of Gene_expression (expression) of pAkt in dorsal horn associated with nmda receptor and dorsal horn
15) Confidence 0.23 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20067569 Disease Relevance 0.25 Pain Relevance 0.26
Facilitation of reflex sensitization and increases in protein expressions of pAkt and pNR2B in dorsal horn were induced after pre-treatment with a subcutaneous injection of 17beta-estradiol (5 microg/kg), 6 h ahead of time, when compared with vehicle solution.
Positive_regulation (increases) of Gene_expression (expressions) of pAkt in dorsal horn associated with dorsal horn
16) Confidence 0.22 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20067569 Disease Relevance 0.24 Pain Relevance 0.27
Facilitation of reflex sensitization and increases in protein expressions of pAkt and pNR2B in dorsal horn were induced after pre-treatment with a subcutaneous injection of 17beta-estradiol (5 microg/kg), 6 h ahead of time, when compared with vehicle solution.
Positive_regulation (induced) of Gene_expression (expressions) of pAkt in dorsal horn associated with dorsal horn
17) Confidence 0.22 Published 2010 Journal J. Neurochem. Section Abstract Doc Link 20067569 Disease Relevance 0.24 Pain Relevance 0.27
, 3-NT and COX-2 expression and increases in Bcl-2 and AKT expression.
Positive_regulation (increases) of Gene_expression (expression) of AKT
18) Confidence 0.21 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635644 Disease Relevance 0.84 Pain Relevance 0.04
Conversely, treatment with the D2R antagonist, haloperidol (10 µM; Fig. 6C, lane 3), or the D1R agonist, SKF38393 (33 µM; Fig. 7C, lane 4), increased levels of both pAkt and pGSK3?
Positive_regulation (increased) of Gene_expression (levels) of pAkt associated with antagonist and agonist
19) Confidence 0.21 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.52
This increase in NCS1 corresponds with a significant increase in phospho-Akt levels (Figure 4C–4D, 4G–4H).
Positive_regulation (increase) of Gene_expression (levels) of Akt
20) Confidence 0.21 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2889931 Disease Relevance 0.10 Pain Relevance 0

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