INT11773

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 56
Total Number 61
Disease Relevance 10.00
Pain Relevance 25.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 8
striatum 6
spinal 2
projection neurons 2
spinal cord 2
Tac1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 114 100.00 Very High Very High Very High
agonist 69 100.00 Very High Very High Very High
Enkephalin 64 100.00 Very High Very High Very High
Neuropeptide 59 100.00 Very High Very High Very High
antagonist 37 100.00 Very High Very High Very High
Dynorphin 25 100.00 Very High Very High Very High
Cholecystokinin 14 100.00 Very High Very High Very High
bradykinin 3 100.00 Very High Very High Very High
Opioid 8 99.90 Very High Very High Very High
Pain 60 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 29 99.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

2 99.82 Very High Very High Very High
Shock 6 99.78 Very High Very High Very High
Injury 21 99.60 Very High Very High Very High
Urological Neuroanatomy 8 99.52 Very High Very High Very High
Infection 2 99.26 Very High Very High Very High
Asthma 1 99.26 Very High Very High Very High
Bronchial Hyperreactivity 1 98.88 Very High Very High Very High
Causalgia 5 98.64 Very High Very High Very High
Nociception 71 98.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The level of PPT mRNA in the striatum was also decreased in response to ADX, but there were no significant diurnal changes in the expression of the PPT mRNA either in the intact or in the ADX animals.
Gene_expression (expression) of PPT mRNA in striatum
1) Confidence 0.77 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1645434 Disease Relevance 0.08 Pain Relevance 0.04
Altered tachykinin expression by dorsal root ganglion neurons in a rat model of neuropathic pain.
Gene_expression (expression) of tachykinin in neurons associated with ganglion cysts, pain, neuropathic pain and root ganglion neuron
2) Confidence 0.76 Published 1994 Journal Pain Section Title Doc Link 7816489 Disease Relevance 0.45 Pain Relevance 0.57
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Gene_expression (expression) of PPT mRNA in neurons associated with injury
3) Confidence 0.76 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.30
In particular, the induction of PPT gene expression by many of the large neurons undergoing degenerative changes may represent an important biochemical parameter which is associated with the development and persistence of experimental allodynia.
Gene_expression (expression) of PPT gene in neurons associated with allodynia
4) Confidence 0.76 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.53 Pain Relevance 0.40
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Gene_expression (expression) of PPT gene in neurons associated with injury
5) Confidence 0.76 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.37
Such elevation of the PPTA mRNA expression in the DRG was observed as early as 3 h after formalin injection.
Gene_expression (expression) of PPTA mRNA in DRG associated with dorsal root ganglion
6) Confidence 0.75 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.53 Pain Relevance 0.26
These results show that the expression of the PPTA gene is activated by chemogenic noxious stimuli.
Gene_expression (expression) of PPTA gene
7) Confidence 0.75 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.41 Pain Relevance 0.25
Four hours after a single injection of the serotonin 2A/2C receptor agonist, (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI; 1 mg/kg), PPT mRNA expression was significantly increased in DA-depleted rats across all dorsal subregions of the rostral and caudal striatum as compared to 6-OHDA-treated animals alone.
Gene_expression (expression) of PPT mRNA in dorsal associated with dopamine, agonist and serotonin
8) Confidence 0.71 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.55
Injury-induced changes in PPT mRNA expression by affected DRG neurons included: (1) at early postoperative times, generally increased levels of PPT mRNA associated with small and intermediate-size B cells exhibiting normal morphology, (2) at late postoperative times, markedly decreased levels of PPT mRNA associated with degenerating B cells, and (3) induction of PPT gene expression by large A cells which is highly correlated with degenerative morphological changes.
Gene_expression (expression) of PPT mRNA in neurons associated with injury
9) Confidence 0.66 Published 1994 Journal Pain Section Abstract Doc Link 7816489 Disease Relevance 0.47 Pain Relevance 0.37
These findings suggest that tachykinins acting on NK2 receptors play a role in the modulation of the spontaneous mechanical activity.
Gene_expression (acting) of tachykinin
10) Confidence 0.65 Published 2000 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 11012946 Disease Relevance 0 Pain Relevance 0.45
The data suggest that sigma receptor activity, directly or indirectly, affects proenkephalin and protachykinin mRNA expression in striatal neurons.
Gene_expression (expression) of protachykinin mRNA in neurons
11) Confidence 0.63 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1968844 Disease Relevance 0 Pain Relevance 0
The changes in PPT mRNA expression were prevented by concurrent local anesthesia of the sciatic nerve.
Gene_expression (expression) of PPT mRNA in sciatic nerve associated with anesthesia and sciatic nerve
12) Confidence 0.63 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 7970189 Disease Relevance 0.32 Pain Relevance 0.57
Although these results support previous studies suggesting an overall positive regulatory role of serotonin on striatal tachykinin biosynthesis, PPT and PPE gene regulation in certain striatal subregions may by differentially sensitive to lowered 5-HT neurotransmission.
Gene_expression (biosynthesis) of tachykinin associated with serotonin
13) Confidence 0.63 Published 1996 Journal Brain Res. Section Abstract Doc Link 8891265 Disease Relevance 0 Pain Relevance 0.20
The selectivity suggests that 5-HT2A receptor upregulation following DA depletion is capable of regulating tachykinin biosynthesis without influencing enkephalin expression in striatal output neurons.
Gene_expression (biosynthesis) of tachykinin in output neurons associated with dopamine and enkephalin
14) Confidence 0.62 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.59
Serotonin 2A receptor regulation of striatal neuropeptide gene expression is selective for tachykinin, but not enkephalin neurons following dopamine depletion.
Gene_expression (selective) of tachykinin in neurons associated with dopamine, neuropeptide, enkephalin and serotonin
15) Confidence 0.61 Published 2001 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.78
In the intact rat, DOI did not influence PPT mRNA levels in the rostral striatum, but did raise expression in the caudal striatum where 5-HT2A receptors are prominent.
Gene_expression (expression) of PPT mRNA in striatum
16) Confidence 0.61 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11483243 Disease Relevance 0 Pain Relevance 0.58
In this work, striatal expression of preprotachykinin (PPT) and preproenkephalin (PPE) mRNA was studied by in situ hybridization in rats killed 2 h after treadmill running (36 m/min for 20 min).
Gene_expression (expression) of PPT
17) Confidence 0.60 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10381545 Disease Relevance 0 Pain Relevance 0.20
We showed previously that lipopolysaccharide (LPS) induces noncholinergic airway hyperreactivity to capsaicin via an upregulation of tachykinin synthesis.
Gene_expression (synthesis) of tachykinin associated with asthma and qutenza
18) Confidence 0.58 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14613715 Disease Relevance 0.10 Pain Relevance 0.10
Analysis of hybridization signals in the emulsion autoradiography showed that the lumbar-5 DRG neurons expressing PPTA mRNAs were significantly increased in number and signal intensity on the formalin-injected side.
Gene_expression (expressing) of PPTA in DRG associated with dorsal root ganglion
19) Confidence 0.57 Published 1988 Journal Brain Res. Section Abstract Doc Link 3179743 Disease Relevance 0.45 Pain Relevance 0.27
The injection of METH did not significantly influence Tac1 expression on the lesioned side (?
Gene_expression (expression) of Tac1
20) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001483 Disease Relevance 0 Pain Relevance 0.18

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