INT117735

Context Info Confidence 0.44 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.93 Pain Relevance 0.91

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1) nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)

Nfkb1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 18 98.72 COX2 2 97.80 cOX1 2 97.80 Analgesic 3 96.36 Rheumatism 1 92.12 Earache 1 91.24 Arthritis 1 66.60 abdominal pain 1 66.16 Crohn's disease 1 57.04 cytokine 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 99.28 Hemophilus Infection 89 99.18 INFLAMMATION 16 98.72 Death 1 96.52 Rheumatic Diseases 1 92.12 Fever 4 91.64 Earache 1 91.24 Disease 5 91.20 Infection 12 89.40 Targeted Disruption 10 75.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-alpha and iNOS expression, which is mediated by NF-kappaB regulation, in RAW264.7 cells.

Positive_regulation (mediated) of Regulation (regulation) of NF-kappaB associated with cox1

1) Confidence 0.44 Published 2009 Journal J Ethnopharmacol Section Title Doc Link 19393729 Disease Relevance 0.46 Pain Relevance 0.74

NTHi induced phosphorylation of p38 MAPK and up-regulated DNA binding activity of NF-kappa B.

Positive_regulation (up) of Regulation (regulated) of NF-kappa B associated with hemophilus infection

2) Confidence 0.20 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 1.14 Pain Relevance 0

These molecules mediate the regulation of nuclear factor-kappa B (NF-kappa B) activation, cell apoptosis, and interleukin-1 beta secretion through cross-regulated and, sometimes, common signaling pathways.

Positive_regulation (mediate) of Regulation (regulation) of NF-kappa B associated with apoptosis

3) Confidence 0.11 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15059033 Disease Relevance 1.34 Pain Relevance 0.18

General Comments

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