INT117735

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Context Info
Confidence 0.44
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.93
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 98.72 Very High Very High Very High
COX2 2 97.80 Very High Very High Very High
cOX1 2 97.80 Very High Very High Very High
Analgesic 3 96.36 Very High Very High Very High
Rheumatism 1 92.12 High High
Earache 1 91.24 High High
Arthritis 1 66.60 Quite High
abdominal pain 1 66.16 Quite High
Crohn's disease 1 57.04 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 99.28 Very High Very High Very High
Hemophilus Infection 89 99.18 Very High Very High Very High
INFLAMMATION 16 98.72 Very High Very High Very High
Death 1 96.52 Very High Very High Very High
Rheumatic Diseases 1 92.12 High High
Fever 4 91.64 High High
Earache 1 91.24 High High
Disease 5 91.20 High High
Infection 12 89.40 High High
Targeted Disruption 10 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardiospermum halicacabum ethanol extract inhibits LPS induced COX-2, TNF-alpha and iNOS expression, which is mediated by NF-kappaB regulation, in RAW264.7 cells.
Positive_regulation (mediated) of Regulation (regulation) of NF-kappaB associated with cox1
1) Confidence 0.44 Published 2009 Journal J Ethnopharmacol Section Title Doc Link 19393729 Disease Relevance 0.46 Pain Relevance 0.74
NTHi induced phosphorylation of p38 MAPK and up-regulated DNA binding activity of NF-kappa B.
Positive_regulation (up) of Regulation (regulated) of NF-kappa B associated with hemophilus infection
2) Confidence 0.20 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 1.14 Pain Relevance 0
These molecules mediate the regulation of nuclear factor-kappa B (NF-kappa B) activation, cell apoptosis, and interleukin-1 beta secretion through cross-regulated and, sometimes, common signaling pathways.
Positive_regulation (mediate) of Regulation (regulation) of NF-kappa B associated with apoptosis
3) Confidence 0.11 Published 2004 Journal Am J Pharmacogenomics Section Abstract Doc Link 15059033 Disease Relevance 1.34 Pain Relevance 0.18

General Comments

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