INT117773

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 0.89
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ptk2) nucleolus (Ptk2) cytoskeleton (Ptk2)
nucleus (Ptk2) extracellular matrix organization (Ptk2) microtubule organizing center (Ptk2)
Anatomy Link Frequency
neuronal 2
nucleus 2
band 2
hippocampus 2
Ptk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 38 99.98 Very High Very High Very High
Hippocampus 2 99.52 Very High Very High Very High
tetrodotoxin 2 99.08 Very High Very High Very High
Kinase C 6 96.12 Very High Very High Very High
anesthesia 3 94.48 High High
antagonist 2 87.68 High High
opioid receptor 4 80.20 Quite High
qutenza 5 75.00 Quite High
dorsal root ganglion 14 5.00 Very Low Very Low Very Low
analgesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 14 100.00 Very High Very High Very High
Death 4 96.84 Very High Very High Very High
Ganglion Cysts 14 5.00 Very Low Very Low Very Low
Sleep Disorders 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low
Diuresis 1 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that lidocaine increases the phosphorylation of focal adhesion kinase (FAK, a nonreceptor tyrosine kinase playing a role in neuronal plasticity and cell death).
Positive_regulation (increases) of Phosphorylation (phosphorylation) of FAK in neuronal associated with lidocaine, death and adhesions
1) Confidence 0.69 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.20 Pain Relevance 0.59
Lidocaine induced a concentration-related increase in FAK phosphorylation while the bupivacaine effect was biphasic.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of FAK associated with lidocaine
2) Confidence 0.69 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.16 Pain Relevance 0.87
RESULTS: Dexmedetomidine produced a dose-related increase in FAK phosphorylation (187 +/- 4%, mean +/- SD, from basal level, EC50 = 0.2 microm; 95% confidence interval, 0.09-0.5 microm).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of FAK
3) Confidence 0.68 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
We conclude that lidocaine increases phosphorylation of the tyrosine kinase PP125FAK in the rat hippocampus by a tetrotoxin (TTX)-insensitive mechanism which involves activation of PKC.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of kinase PP125FAK in hippocampus associated with kinase c, hippocampus and lidocaine
4) Confidence 0.60 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063155 Disease Relevance 0.14 Pain Relevance 0.63
FAK phosphorylation and caspase-3 activation were examined by immunoblotting.
Spec (examined) Positive_regulation (activation) of Phosphorylation (phosphorylation) of FAK
5) Confidence 0.49 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
Lidocaine induced a concentration-related increase in FAK phosphorylation while the bupivacaine effect was biphasic.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of FAK associated with lidocaine
6) Confidence 0.46 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17179255 Disease Relevance 0.16 Pain Relevance 0.87
Lidocaine induced a concentration-related increase in tyrosine phosphorylation of the 125-kDa band corresponding to PP125FAK phosphorylation (EC50 value=0.39+/-0.09 microM, maximal effect=169+/-28% of control, P<0.001).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of PP125FAK in band associated with lidocaine
7) Confidence 0.46 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15063155 Disease Relevance 0.17 Pain Relevance 0.57
Increase in phosphorylation of FAK via stimulation of alpha2 adrenoceptors and decrease in cleaved caspase-3 expression correlate with dexmedetomidine-induced cell survival.


Positive_regulation (Increase) of Phosphorylation (phosphorylation) of FAK
8) Confidence 0.46 Published 2005 Journal Anesthesiology Section Body Doc Link 16249671 Disease Relevance 0 Pain Relevance 0
Dual action of epidermal growth factor: extracellular signal-stimulated nuclear–cytoplasmic export and coordinated translation of selected messenger RNA

EGF triggers dephosphorylation of the mRNA-binding protein Grb7 in the nucleus, leading to its export, and it also stimulates FAK, which rephosphorylates Grb7 in the cytoplasm to release its mRNA cargo for translation.


Positive_regulation (triggers) of Phosphorylation (dephosphorylation) of FAK in nucleus
9) Confidence 0.34 Published 2010 Journal The Journal of Cell Biology Section Title Doc Link PMC2819679 Disease Relevance 0.06 Pain Relevance 0.04
Importantly, capsiate suppressed VEGF-induced activation of Src kinase and phosphorylation of its downstream substrates, such as p125(FAK) and VE-cadherin, without affecting autophosphorylation of the VEGF receptor KDR/Flk-1.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of FAK
10) Confidence 0.07 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18172315 Disease Relevance 0 Pain Relevance 0.14

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