INT117794

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.15
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal 2
spinal cord 2
Hpcl1 (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 94 99.68 Very High Very High Very High
qutenza 164 98.54 Very High Very High Very High
Neuropeptide 2 88.40 High High
medulla 34 38.32 Quite Low
Root ganglion neuron 6 5.00 Very Low Very Low Very Low
ASIC 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Dorsal horn 4 5.00 Very Low Very Low Very Low
superficial lamina 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 10 75.00 Quite High
Pressure And Volume Under Development 8 24.96 Low Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Nociception 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Dyspepsia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The failure of gastric HCl challenge to induce c-fos expression in the spinal cord cannot be explained by the reported ability of vagal afferents to activate descending pathways and thereby inhibit afferent input to the spinal cord [44,45], because bilateral chronic vagotomy fails to reveal any increase in spinal c-fos mRNA induction due to gastric HCl challenge [5].
HCl Positive_regulation (induce) of Gene_expression (expression) of c-fos in spinal associated with spinal cord
1) Confidence 0.17 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0 Pain Relevance 1.04
Pretreatment with capsaicin or hexamethonium, combination of both pretreatments or vagotomy reduced HCl-induced c-Fos expression by 54%, 66%, 63% and 68%, respectively.
HCl Positive_regulation (induced) of Gene_expression (expression) of c-Fos associated with qutenza
2) Confidence 0.14 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15066018 Disease Relevance 0.07 Pain Relevance 0.30
Intragastric (IG) administration of 0.5 m HCl caused c-Fos expression in 12% of myenteric neurones, whereas IG saline failed to induce c-Fos.
HCl Positive_regulation (caused) of Gene_expression (expression) of c-Fos
3) Confidence 0.14 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 15066018 Disease Relevance 0.07 Pain Relevance 0.20
In agreement with previous findings [5], IG exposure to 0.5 M HCl failed to induce any expression of c-fos mRNA in the dorsal half of the caudal thoracic spinal cord.
HCl Neg (failed) Positive_regulation (induce) of Gene_expression (expression) of c-fos mRNA in spinal cord associated with spinal cord
4) Confidence 0.13 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0 Pain Relevance 0.43

General Comments

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