INT117808

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.12
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Itgal)
Anatomy Link Frequency
endothelial cells 2
monocyte 2
T cells 2
Itgal (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 2 97.20 Very High Very High Very High
rheumatoid arthritis 1 69.52 Quite High
chemokine 15 66.88 Quite High
Inflammation 3 58.12 Quite High
imagery 10 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 6 99.78 Very High Very High Very High
Systemic Lupus Erythematosus 25 98.04 Very High Very High Very High
Disease 4 97.60 Very High Very High Very High
Cv General 3 Under Development 2 97.20 Very High Very High Very High
Adhesions 9 86.80 High High
Rheumatoid Arthritis 1 69.52 Quite High
Syndrome 8 67.00 Quite High
Infection 3 58.32 Quite High
INFLAMMATION 3 58.12 Quite High
Hepatitis 17 56.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of CD1d-reactive T cells in the liver has been shown to require LFA-1 expression on liver cells other than NKT cells [15], which implicates hematopoietic cells such as Kupffer cells in capture of NKT cells since endothelial cells do not express LFA-1.
Positive_regulation (require) of Gene_expression (expression) of LFA-1 in endothelial cells
1) Confidence 0.10 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1073691 Disease Relevance 0.45 Pain Relevance 0.07
Autoreactivity correlated with over-expression at a transcriptional level of lymphocyte function-associated antigen-1 (LFA-1) [73], and T cells overexpressing this molecule become auto-reactive and caused a lupus-like disease in syngeneic mice [74] as it did in mice injected with syngeneic normal murine T cells treated with demethylating drugs [75,76].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of LFA-1 in T cells associated with disease and systemic lupus erythematosus
2) Confidence 0.06 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.78 Pain Relevance 0.06
In the AMI group the expression of monocyte CD11a was significantly increased after 6 hours, and CD18 and ICAM-1 expression were also significantly increased after 12 hours, whereas that of monocyte L-selectin was increased after 72 hours.
Positive_regulation (increased) of Gene_expression (expression) of CD11a in monocyte associated with myocardial infarction
3) Confidence 0.05 Published 2004 Journal J. Atheroscler. Thromb. Section Abstract Doc Link 15067196 Disease Relevance 0.90 Pain Relevance 0.10

General Comments

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