INT117827

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PHEX) protein modification process (PHEX) Golgi apparatus (PHEX)
endoplasmic reticulum (PHEX) plasma membrane (PHEX) cell-cell signaling (PHEX)
Anatomy Link Frequency
cleavage 1
PHEX (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 84.32 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 106 100.00 Very High Very High Very High
Familial Hypophosphatemia 3 97.76 Very High Very High Very High
Hypophosphatemia 14 97.68 Very High Very High Very High
Disease 25 95.32 Very High Very High Very High
Stomatognathic Diseases /

Tooth Disease

7 93.32 High High
Bone Cancer 1 73.36 Quite High
Growth Problems 2 23.32 Low Low
Cancer 13 5.00 Very Low Very Low Very Low
Kidney Stones 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
XLH is the most common form of FHR and results from a mutation in the PHEX gene.
Positive_regulation (results) of XLH associated with rickets
1) Confidence 0.41 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2694264 Disease Relevance 0.55 Pain Relevance 0
This is followed by endopeptidases and/or exopeptidases mediated cleavage of the oligopeptides which, in turn, produces a multiplicity of short peptides differing by one or more amino acid residues.
Positive_regulation (mediated) of endopeptidases in cleavage
2) Confidence 0.30 Published 2004 Journal J. Dairy Res. Section Abstract Doc Link 15068070 Disease Relevance 0 Pain Relevance 0.08
Although FGF23 concentrations are not invariably increased in XLH, an inverse relationship between FGF23 and the degree of hypophosphataemia has been found [25].
Neg (not) Positive_regulation (increased) of XLH associated with rickets and hypophosphatemia
3) Confidence 0.03 Published 2008 Journal Eur J Pediatr Section Body Doc Link PMC2668657 Disease Relevance 0.95 Pain Relevance 0

General Comments

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