INT117828

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.80
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcb1b) mitochondrion (Abcb1b) ATPase activity (Abcb1b)
transmembrane transport (Abcb1b)
Anatomy Link Frequency
intestine 4
NIH-3T3 2
lung 1
kidney 1
Abcb1b (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 37 100.00 Very High Very High Very High
Analgesic 6 99.48 Very High Very High Very High
Cancer pain 3 91.24 High High
Opioid 4 90.52 High High
analgesia 3 78.88 Quite High
Central nervous system 3 48.32 Quite Low
Pain 1 25.00 Low Low
anesthesia 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
vincristine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 83 99.32 Very High Very High Very High
Cancer Pain 3 91.24 High High
Infection 25 72.88 Quite High
Falciparum Malaria 1 62.56 Quite High
Malaria 8 50.00 Quite Low
Congenital Anomalies 3 47.28 Quite Low
Pressure And Volume Under Development 3 46.56 Quite Low
Hyperplasia 3 45.24 Quite Low
Hydrothorax 6 37.96 Quite Low
Leukemoid Reaction 3 25.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of short-term morphine exposure on P-glycoprotein expression and activity in cancer cell lines.
Regulation (Effect) of Gene_expression (expression) of P-glycoprotein associated with cancer and morphine
1) Confidence 0.60 Published 2004 Journal Oncol. Rep. Section Title Doc Link 15069552 Disease Relevance 0.42 Pain Relevance 0.84
The effect of morphine on P-glycoprotein expression and activity in the mouse fibroblast NIH-3T3 cell was assessed to establish whether morphine effects are species specific.
Regulation (effect) of Gene_expression (expression) of P-glycoprotein in NIH-3T3 associated with morphine
2) Confidence 0.60 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.41 Pain Relevance 0.98
We previously found that morphine and fentanyl showed higher analgesic potencies in P-gp-deficient mice compared with those in wild-type mice, suggesting that their analgesic effects are considerably dependent on P-gp expression.
Regulation (dependent) of Gene_expression (expression) of P-gp associated with analgesic and morphine
3) Confidence 0.60 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18071274 Disease Relevance 0 Pain Relevance 1.10
Using Western blot analysis and cytotoxicity assays respectively, we have investigated the effects of short-term (72 h) morphine treatment on P-glycoprotein expression in a panel of human cancer cell lines, and its effects on cellular resistance to the known P-glycoprotein substrates, vinblastine and colchicine.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of P-glycoprotein associated with cancer and morphine
4) Confidence 0.44 Published 2004 Journal Oncol. Rep. Section Abstract Doc Link 15069552 Disease Relevance 0.41 Pain Relevance 0.84
Either of these outcomes could perturb the overall regulation of mdr1 mRNA and protein expression.
Regulation (regulation) of Gene_expression (expression) of mdr1
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904698 Disease Relevance 0.14 Pain Relevance 0
On Day 7 after BMT, expression of human MDR1 and P-gp could be detected in kidney, lung and intestine of mice in group A and C (Figure 4).
Regulation (detected) of Gene_expression (expression) of MDR1 in intestine
6) Confidence 0.34 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.14 Pain Relevance 0
On Day 7 after BMT, expression of human MDR1 and P-gp could be detected in kidney, lung and intestine of mice in group A and C (Figure 4).
Regulation (detected) of in kidney Gene_expression (expression) of MDR1 in intestine
7) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.14 Pain Relevance 0
On Day 7 after BMT, expression of human MDR1 and P-gp could be detected in kidney, lung and intestine of mice in group A and C (Figure 4).
Regulation (detected) of in lung Gene_expression (expression) of MDR1 in intestine
8) Confidence 0.11 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2819043 Disease Relevance 0.14 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox