INT117849

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 8.75
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGFBP3) extracellular region (IGFBP3) nucleus (IGFBP3)
Anatomy Link Frequency
fibroblasts 4
blood 2
IGFBP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 99.36 Very High Very High Very High
cytokine 41 98.36 Very High Very High Very High
fibrosis 10 98.28 Very High Very High Very High
Inflammation 10 90.48 High High
Dynorphin 5 87.92 High High
alcohol 2 75.00 Quite High
medulla 10 72.64 Quite High
rheumatoid arthritis 77 71.44 Quite High
nMDA receptor 5 48.96 Quite Low
Hippocampus 5 27.44 Quite Low
Disease Link Frequency Relevance Heat
Cancer 24 100.00 Very High Very High Very High
Malignant Neoplastic Disease 11 100.00 Very High Very High Very High
Sleep Disorders 345 99.96 Very High Very High Very High
Apoptosis 68 99.72 Very High Very High Very High
Adhesions 381 99.68 Very High Very High Very High
Pancreatitis 3 99.36 Very High Very High Very High
Hyperglycemia 5 99.32 Very High Very High Very High
Congenital Anomalies 7 98.44 Very High Very High Very High
Fibrosis 11 98.28 Very High Very High Very High
Injury 52 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decrease in the levels of IGFBP-3 in the adhesion fibroblasts may promote adhesion development both by increasing proliferation and reducing apoptosis at the site of injury.
Negative_regulation (Decrease) of Gene_expression (levels) of IGFBP-3 in fibroblasts associated with injury, apoptosis and adhesions
1) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.36 Pain Relevance 0
Reduced levels of IGFBP3 mRNA are reported in the tumorigenic cells [38].
Negative_regulation (Reduced) of Gene_expression (levels) of IGFBP3 mRNA
2) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.19 Pain Relevance 0
It is apparent now that higher proliferative and reduced apoptotic nature of adhesion fibroblasts in human as reported earlier [5] could also derive from altered expression of hMet1-e, CSPG2, S100A10, CSPG2, IGFBP3, and the Bfl-1 that inhibits p53-induced apoptosis and is induced by cytokines TNF-?
Negative_regulation (inhibits) of Gene_expression (expression) of IGFBP3 in fibroblasts associated with apoptosis, adhesions and cytokine
3) Confidence 0.39 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC548295 Disease Relevance 1.86 Pain Relevance 0.15
For example, IGFBP3 expression in cancer cells and in the circulation is associated with less malignant growth and decreased cancer risk in breast [29], prostate [30] and other cancers [31].
Negative_regulation (decreased) of Gene_expression (expression) of IGFBP3 associated with malignant neoplastic disease and cancer
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.83 Pain Relevance 0
Although these effects could be indirectly mediated by minor endocrine abnormalities in these animals, for example hyperglycemia [33], the in vitro findings that IGFBP3 expression suppresses HCRT promotor activity (Fig. 3E) and that the functional IGFBP3 polymorphism rs2854744 is associated with reduced hypocretin transmission, observed as lower levels of Hcrt-1 in human CSF (Fig. 3F), makes this hypothesis unlikely.
Negative_regulation (suppresses) of Gene_expression (expression) of IGFBP3 associated with hyperglycemia and congenital anomalies
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.86 Pain Relevance 0.04
Evaluation of IGFBP3 levels, genotype, and IGFBP3 antibodies in blood and CSF of narcoleptic patients
Negative_regulation (blood) of Gene_expression (antibodies) of IGFBP3 in blood
6) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.50 Pain Relevance 0.04
Evaluation of hypocretin and IGFBP3 levels, antibodies and IGFBP3 genotyping
Negative_regulation (Evaluation) of Gene_expression (levels) of IGFBP3
7) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.13 Pain Relevance 0
Mean levels of IGFBP3 in age and sex matched narcolepsy patients (all with low CSF hypocretin-1) versus controls were 59.4±3.4 ng/ml (n?
Negative_regulation (matched) of Gene_expression (levels) of IGFBP3 associated with sleep disorders
8) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.60 Pain Relevance 0.04
Reduced serum concentrations of IGFBP-3 can result from a primary decrease in IGFBP-3 production, or secondarily, due to a reduction in IGF-I.
Negative_regulation (decrease) of Gene_expression (production) of IGFBP-3
9) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.52 Pain Relevance 0.13
Secondary outcome measures were reduction in serum IGF binding protein-3 (IGFBP-3), improvement of fatigue and sweating, and reduction in markers of bone metabolism and bone pain.
Negative_regulation (reduction) of Gene_expression (reduction) of IGFBP-3
10) Confidence 0.16 Published 2006 Journal J. Clin. Endocrinol. Metab. Section Body Doc Link 16720661 Disease Relevance 0.08 Pain Relevance 0
Secondary outcome measures were reduction in serum IGF binding protein-3 (IGFBP-3), improvement of fatigue and sweating, and reduction in markers of bone metabolism and bone pain.
Negative_regulation (reduction) of Gene_expression (reduction) of IGF binding protein-3
11) Confidence 0.16 Published 2006 Journal J. Clin. Endocrinol. Metab. Section Body Doc Link 16720661 Disease Relevance 0.08 Pain Relevance 0
The aim of this study was to evaluate the circulating levels of IL-6, MCP-1, TGF-beta1, IGF-1 and IGFBP-3 in patients with alcoholic chronic pancreatitis (CP).
Negative_regulation (evaluate) of Gene_expression (levels) of IGFBP-3 associated with chronic pancreatitis
12) Confidence 0.05 Published 2004 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 15074399 Disease Relevance 0.74 Pain Relevance 0.35

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