INT11787

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Context Info
Confidence 0.21
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.97
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
sensory neurons 2
blood 2
neurons 2
brain 2
skeletal muscle 2
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 4 99.96 Very High Very High Very High
fibrosis 6 99.90 Very High Very High Very High
tetrodotoxin 11 99.40 Very High Very High Very High
sodium channel 39 98.32 Very High Very High Very High
chemokine 20 98.30 Very High Very High Very High
antagonist 2 97.92 Very High Very High Very High
opiate 6 97.48 Very High Very High Very High
narcan 3 97.04 Very High Very High Very High
lidocaine 11 97.00 Very High Very High Very High
agonist 10 96.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 31 99.96 Very High Very High Very High
Cystic Fibrosis 6 99.90 Very High Very High Very High
Polyuria 1 99.18 Very High Very High Very High
Multiple System Atrophy 5 98.80 Very High Very High Very High
INFLAMMATION 93 91.16 High High
Sepsis 4 91.12 High High
Nervous System Injury 6 90.48 High High
Ganglion Cysts 4 89.64 High High
Heart Rate Under Development 11 89.36 High High
Diuresis 14 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ileal BBMVs, loperamide stimulated intravesicular accumulation of Na+ in the presence of Cl- and vice versa.
Positive_regulation (stimulated) of Positive_regulation (accumulation) of Na
1) Confidence 0.21 Published 1988 Journal Gastroenterology Section Abstract Doc Link 2836258 Disease Relevance 0 Pain Relevance 0.08
These results demonstrated that 10% HS administration did not cause an abnormal accumulation of Na+ in the brain tissue.
Neg (not) Positive_regulation (cause) of Positive_regulation (accumulation) of Na in brain
2) Confidence 0.13 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3004923 Disease Relevance 0.24 Pain Relevance 0
Carbachol (0.5 or 2.0 nmol) induced an increase in Na+ and K+ excretion, water intake and blood pressure and reduced the urinary volume.
Positive_regulation (induced) of Positive_regulation (increase) of Na in blood
3) Confidence 0.12 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1596737 Disease Relevance 0.50 Pain Relevance 0.64
In preliminary experiments with the profile migration method, we confirmed many of the results of Crespo et al17: the elevated permeability of Pcat to Na+ and K+ and the lack of effect of many transport inhibitors (ouabain, amiloride, bumetanide, furosemide, tetrodotoxin, chlorpromazine, trifluoroperazine, oligomycin, mepacrine, and tetracaine).
Positive_regulation (elevated) of Positive_regulation (permeability) of Na associated with tetrodotoxin
4) Confidence 0.11 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0 Pain Relevance 0.10
Thus, the diuretic effect is not related to an osmotic type of mechanism.[12] Furthermore, osmotic diuretics are orally inactive and usually given intravenously.[22] The diuretic effect of BTI is also unlikely to be due to an impairment of the action of antidiuretic hormone because such an impairment causes polyuria with low osmolarity.[23] Loop diuretics causes increase in urinary Na+ and Cl?
Positive_regulation (causes) of Positive_regulation (increase) of Na associated with polyuria
5) Confidence 0.09 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2992138 Disease Relevance 0.32 Pain Relevance 0
At standardized pH conditions, the increase in cellular Na+, as induced by NaCl at 10 mM, was coupled by the two sodium channel-modulating agents lidocaine hydrochloride at 1 ?
Positive_regulation (induced) of Positive_regulation (increase) of Na associated with sodium channel and lidocaine
6) Confidence 0.08 Published 2004 Journal Biol Proced Online Section Abstract Doc Link PMC443562 Disease Relevance 0 Pain Relevance 0.15
There are reports that PTX opens an H+ conductive pathway which results in activation of the Na+/H+ exchanger [116, 117].
Positive_regulation (results) of Positive_regulation (activation) of Na
7) Confidence 0.05 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525493 Disease Relevance 0 Pain Relevance 0.08
A continuous Na+ influx was demonstrated by both the Na+-dependent leakage current and tetrodotoxin-sensitive Na+ current, which resulted in the continuous activation of the Na/K pump.
Positive_regulation (resulted) of Positive_regulation (activation) of Na associated with tetrodotoxin
8) Confidence 0.05 Published 1998 Journal Brain Res. Section Abstract Doc Link 9685682 Disease Relevance 0 Pain Relevance 0.13
In isolated congenital CFTR dysfunction (cystic fibrosis) an increase in sodium transport by an increase in apical ENaC and basolateral Na/K ATPase activity in the airways can compensate for a reduction in alveolar chloride and sodium transport.
Positive_regulation (increase) of Positive_regulation (increase) of Na associated with fibrosis and cystic fibrosis
9) Confidence 0.05 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1562419 Disease Relevance 0.99 Pain Relevance 0.13
Activation of Na+/H+ exchange is required for regulatory volume decrease after modest "physiological" volume increases in jejunal villus epithelial cells.
Positive_regulation (required) of Positive_regulation (Activation) of Na in villus
10) Confidence 0.02 Published 1996 Journal J. Biol. Chem. Section Title Doc Link 8798507 Disease Relevance 0 Pain Relevance 0.08
An induction of RNA synthesis was obtained, without previous activation of the nicotinic receptors, by incubating the ganglia at rest in conditions which entail the generation of an hyperpolarization resulting from the activation of the Na(+)-K- pump, i.e. low external KCl as well as application of TTX following an aconitine treatment.
Positive_regulation (resulting) of Positive_regulation (activation) of Na in external associated with tetrodotoxin
11) Confidence 0.02 Published 1988-1989 Journal J. Physiol. (Paris) Section Abstract Doc Link 2483173 Disease Relevance 0 Pain Relevance 0.22
In this study we found that overnight incubation with GRO/KC (CXCL1), a chemokine that is rapidly upregulated in the DRG in several different models of chronic pain, caused increased excitability and marked upregulation of Na+ current amplitudes in acutely isolated small diameter DRG neurons in short-term culture.
Positive_regulation (caused) of Positive_regulation (upregulation) of Na in neurons associated with chemokine and lasting pain
12) Confidence 0.02 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0.32 Pain Relevance 0.37
We report that GRO/KC incubation (1.5 nM, overnight) caused marked upregulation of Na+ currents in acutely isolated small diameter rat (adult) sensory neurons in vitro.
Positive_regulation (caused) of Positive_regulation (upregulation) of Na in sensory neurons
13) Confidence 0.02 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2562993 Disease Relevance 0.52 Pain Relevance 0.37
Administration of insulin to preparations of skeletal muscle causes an increase in Na(+)-K+ pump activity within 15-30 min.
Positive_regulation (causes) of Positive_regulation (increase) of Na in skeletal muscle
14) Confidence 0.01 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8166238 Disease Relevance 0.06 Pain Relevance 0.11

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