INT117878

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.35
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nos2) signal transduction (Nos2) extracellular space (Nos2)
aging (Nos2) peroxisome (Nos2) nucleus (Nos2)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 2 91.92 High High
cINOD 2 85.64 High High
withdrawal 1 6.28 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
narcan 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 1 99.56 Very High Very High Very High
Urological Neuroanatomy 2 99.08 Very High Very High Very High
Adenocarcinoma 9 94.44 High High
INFLAMMATION 6 85.08 High High
Colon Cancer 4 85.08 High High
Functional Bowel Disorder 3 80.24 Quite High
Adenoma 3 79.36 Quite High
Duodenogastric Reflux 3 79.04 Quite High
Targeted Disruption 2 77.80 Quite High
Metaplasia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, PGE2 mediates up-regulation of iNOS in murine breast cancer cell line through EP4 receptors activation (26).
Positive_regulation (mediates) of Regulation (regulation) of iNOS associated with breast cancer
1) Confidence 0.41 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808576 Disease Relevance 0.88 Pain Relevance 0.04
Enhancedlevel of marrow RNS resulted from the up-regulation of iNOS increased 3.5, times, compared to control, while the cNOS completely suppressed.
Positive_regulation (increased) of Regulation (regulation) of iNOS
2) Confidence 0.33 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.08 Pain Relevance 0
The development of intestinal lesions as induced by indomethacin was accompanied by increases in intestinal motility, enterobacterial invasion, and myeloperoxidase (MPO) as well as inducible nitric oxide synthase (iNOS) activity, together with the up-regulation of COX-2 and iNOS mRNA expression.
Positive_regulation (up) of Regulation (regulation) of iNOS associated with urological neuroanatomy
3) Confidence 0.15 Published 2003 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15075458 Disease Relevance 0.39 Pain Relevance 0.21

General Comments

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