INT1179

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 2
Speculated 6
Reported most in Abstract
Documents 157
Total Number 163
Disease Relevance 67.03
Pain Relevance 30.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
heart 14
blood 7
plasma 6
brain 4
Hip 2
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 232 100.00 Very High Very High Very High
Enkephalin 46 100.00 Very High Very High Very High
amygdala 6 100.00 Very High Very High Very High
antagonist 269 99.92 Very High Very High Very High
Pain 24 99.90 Very High Very High Very High
rheumatoid arthritis 50 99.84 Very High Very High Very High
Inflammation 282 99.82 Very High Very High Very High
substance P 33 99.76 Very High Very High Very High
Calcium channel 42 99.72 Very High Very High Very High
dexamethasone 12 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 1246 100.00 Very High Very High Very High
Coronary Stenosis 5 99.92 Very High Very High Very High
Pain 14 99.90 Very High Very High Very High
Rheumatoid Arthritis 50 99.84 Very High Very High Very High
Hypertrophy 124 99.82 Very High Very High Very High
Heart Rate Under Development 97 99.76 Very High Very High Very High
Cough 74 99.74 Very High Very High Very High
Pathologic Constriction 7 99.62 Very High Very High Very High
Renal Disease 117 99.52 Very High Very High Very High
Injury 109 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that the antihypertensive action could be attributed to a vascular-relaxing mechanism that would occur in vivo independently of angiotensin I-converting enzyme (ACE) inhibition, because neither these peptides nor their main digestion fragments, except for the dipeptide YR, acted as ACE inhibitors in vitro.
Negative_regulation (inhibition) of ACE
1) Confidence 0.59 Published 2007 Journal J. Agric. Food Chem. Section Abstract Doc Link 18047278 Disease Relevance 0.09 Pain Relevance 0.13
Our results suggest that the antihypertensive action could be attributed to a vascular-relaxing mechanism that would occur in vivo independently of angiotensin I-converting enzyme (ACE) inhibition, because neither these peptides nor their main digestion fragments, except for the dipeptide YR, acted as ACE inhibitors in vitro.
Negative_regulation (inhibition) of angiotensin I-converting enzyme
2) Confidence 0.59 Published 2007 Journal J. Agric. Food Chem. Section Abstract Doc Link 18047278 Disease Relevance 0.09 Pain Relevance 0.13
These findings suggest that Bulbus Fritillaria extracts have a hypotensive effect in rats via the inhibition of ACE activity and direct release of NO/cGMP in the vascular tissue.
Negative_regulation (inhibition) of ACE associated with hypotension
3) Confidence 0.58 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 12020927 Disease Relevance 0.24 Pain Relevance 0
The results from this study support those advocating ACE inhibition in managing appropriate patients with peripheral arterial insufficiency.
Negative_regulation (inhibition) of ACE associated with cva and increased venous pressure under development
4) Confidence 0.58 Published 1994 Journal J Clin Pharmacol Section Abstract Doc Link 8006202 Disease Relevance 0.25 Pain Relevance 0.20
Antihypertensive therapy in nephrectomized donors should include an ACE inhibitor or an angiotensin-II antagonist.
Negative_regulation (inhibitor) of ACE associated with antagonist
5) Confidence 0.58 Published 1995 Journal Ther Umsch Section Abstract Doc Link 7502264 Disease Relevance 0.43 Pain Relevance 0.17
ACE inhibition did not affect body weight, blood pressure, or heart rate of the rats during exercise.
Negative_regulation (inhibition) of ACE in blood associated with body weight
6) Confidence 0.58 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8397181 Disease Relevance 0.10 Pain Relevance 0.12
These results indicate that collateral-dependent BF was improved by ACE inhibition.
Negative_regulation (inhibition) of ACE
7) Confidence 0.58 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8397181 Disease Relevance 0.08 Pain Relevance 0.08
The angiotensin-converting enzyme (ACE) activities were inhibited significantly by the addition of berberine in a dose-dependent manner of which the IC50 value of berberine for ACE was 42 micrograms/ml (125 microM).
Negative_regulation (inhibited) of ACE
8) Confidence 0.57 Published 2002 Journal Vascul. Pharmacol. Section Abstract Doc Link 14567065 Disease Relevance 0 Pain Relevance 0
These data indicate that SCH 31846 is a potent and specific non-sulfhydryl ACE inhibitor.
Negative_regulation (inhibitor) of ACE
9) Confidence 0.57 Published 1983 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6193364 Disease Relevance 0 Pain Relevance 0.13
Inhibition of the angiotensin I converting enzyme with SQ 20.881 results in a 2 to 35 fold increase in plasma renin concentration in normal rats and in spontaneously hypertensive rats.
Negative_regulation (Inhibition) of angiotensin I converting enzyme in plasma associated with hypertension
10) Confidence 0.57 Published 1975 Journal Acta Pathol Microbiol Scand A Section Abstract Doc Link 170788 Disease Relevance 0.23 Pain Relevance 0
To determine if peptidase inhibition potentiates C-fiber activation, we challenged pulmonary C-fibers in rats with capsaicin or bradykinin before and after inhibition of neutral endopeptidase (NEP) or angiotensin converting enzyme (ACE).
Negative_regulation (inhibition) of ACE associated with c fibre, qutenza and bradykinin
11) Confidence 0.57 Published 1997 Journal Respir Physiol Section Abstract Doc Link 9108624 Disease Relevance 0 Pain Relevance 1.36
Therefore, inhibition of NEP or ACE may potentiate airway obstructive mechanisms initiated by C-fiber stimulation.
Negative_regulation (inhibition) of ACE associated with c fibre
12) Confidence 0.57 Published 1997 Journal Respir Physiol Section Abstract Doc Link 9108624 Disease Relevance 0 Pain Relevance 1.36
Idrapril and captopril reduced the blood pressure and potentiated substance P-induced bronchoconstriction in the guinea pig to the same extent, suggesting a similar degree of ACE inhibition in the circulation.
Negative_regulation (inhibition) of ACE in blood associated with substance p
13) Confidence 0.56 Published 1992 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1383623 Disease Relevance 0.35 Pain Relevance 0.19
Inhibition of the ACE reverses the torasemide-induced increase in apparent Na pump density in principal cells and seems to shift the relationship between hypertrophy and hyperplasia noted in DCT and CCD after chronic torasemide in favor of hyperplasia.
Negative_regulation (Inhibition) of ACE in CCD associated with hypertrophy and hyperplasia
14) Confidence 0.56 Published 1997 Journal Kidney Int. Section Abstract Doc Link 8995715 Disease Relevance 0.35 Pain Relevance 0
Thus, in contrast to its salutary effects at later ages, ACE inhibition can worsen injury to the partially obstructed kidney during renal maturation even after the completion of nephrogenesis.
Negative_regulation (inhibition) of ACE in kidney associated with injury
15) Confidence 0.56 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17107943 Disease Relevance 0.70 Pain Relevance 0.06
In a subset analysis, 366 patients who were not receiving ACE inhibitors were randomly assigned to either valsartan or placebo.
Neg (not) Negative_regulation (inhibitors) of ACE
16) Confidence 0.56 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.66 Pain Relevance 0.03
The ACE activity was decreased two-fold in thalamo-hypothalamic region of ethanol-preferring rats.
Negative_regulation (decreased) of ACE
17) Confidence 0.55 Published 1991 Journal Vopr. Med. Khim. Section Abstract Doc Link 1661050 Disease Relevance 0 Pain Relevance 0.25
Attenuation of heart failure due to coronary stenosis by ACE inhibitor and angiotensin receptor blocker.
Negative_regulation (inhibitor) of ACE in heart associated with coronary stenosis, anesthesia and myocardial infarction
18) Confidence 0.55 Published 2003 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 12649073 Disease Relevance 0.90 Pain Relevance 0.13
When given alone, neither phosphoramidon, an inhibitor of NEP, nor captopril, an inhibitor of ACE, completely reversed this effect of dexamethasone, but when the two drugs were administered together, adherent neutrophils were as numerous in the dexamethasone-pretreated rats (112 +/- 9 neutrophils/mm2) as in controls (109 +/- 10 neutrophils/mm2).
Negative_regulation (inhibitor) of ACE in neutrophils associated with dexamethasone
19) Confidence 0.52 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8460720 Disease Relevance 0.27 Pain Relevance 0.59
Effects of inhibition of angiotensin converting enzyme (ACE, EC 3.4.15.1) in brain on psychomotor, exploratory, stereotyped and cognitive behaviour in rats were investigated.
Negative_regulation (inhibition) of ACE in brain associated with cognitive disorder
20) Confidence 0.51 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2279685 Disease Relevance 0.17 Pain Relevance 0

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