INT117909

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Mastl, Mapk1) nucleus (Mastl, Mapk1) cytoskeleton (Mastl, Mapk1)
cell cycle (Mastl, Mapk1) kinase activity (Mastl, Mapk1) nucleoplasm (Mapk1)
Anatomy Link Frequency
striatum 2
Mastl (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 6 100.00 Very High Very High Very High
cocaine 4 99.30 Very High Very High Very High
addiction 2 94.00 High High
Morphine 2 67.52 Quite High
Nicotine 2 66.72 Quite High
antidepressant 4 59.84 Quite High
Nucleus accumbens 2 47.44 Quite Low
amygdala 4 41.68 Quite Low
Dopamine 2 37.12 Quite Low
cerebral cortex 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cocaine and delta-9-tetrahydrocannabinol (THC) activate extracellular signal-regulated kinase (ERK) in the striatum and blockade of the ERK pathway prevents establishment of conditioned place preference to these drugs.
THC Positive_regulation (activate) of ERK in striatum associated with delta-9-tetrahydrocannabinol and cocaine
1) Confidence 0.04 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078556 Disease Relevance 0 Pain Relevance 0.39
Cocaine and delta-9-tetrahydrocannabinol (THC) activate extracellular signal-regulated kinase (ERK) in the striatum and blockade of the ERK pathway prevents establishment of conditioned place preference to these drugs.
THC Positive_regulation (activate) of extracellular signal-regulated kinase in striatum associated with delta-9-tetrahydrocannabinol and cocaine
2) Confidence 0.04 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15078556 Disease Relevance 0 Pain Relevance 0.39

General Comments

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