INT117912

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1, MAPK1) mitochondrion (CREB1, MAPK1) signal transduction (CREB1, MAPK1)
nucleus (CREB1, MAPK1) transcription factor binding (CREB1, MAPK1) Golgi apparatus (MAPK1)
CREB1 (Homo sapiens)
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 91.64 High High
cINOD 1 84.64 Quite High
Disease Link Frequency Relevance Heat
Colon Cancer 5 86.52 High High
INFLAMMATION 1 84.40 Quite High
Apoptosis 5 78.40 Quite High
Stress 1 69.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies with pharmacological inhibitors revealed that cAMP-dependent phosphorylation of CREB required activation of ERK1/2 and p38 MAPK but was largely independent of protein kinase A.
CREB Positive_regulation (required) of Positive_regulation (activation) of ERK1/2
1) Confidence 0.04 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.89 Pain Relevance 0.13

General Comments

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