INT117915

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Context Info
Confidence 0.63
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 6.74
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BIRC2) intracellular (BIRC2) cytoplasm (BIRC2)
Anatomy Link Frequency
colon 1
T84 1
NK cell 1
skin 1
BIRC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 98.56 Very High Very High Very High
fibrosis 6 97.04 Very High Very High Very High
cINOD 3 95.60 Very High Very High Very High
Chronic pancreatitis 14 95.52 Very High Very High Very High
cytokine 13 86.36 High High
Inflammation 11 47.96 Quite Low
melanocortin 1 receptor 3 45.84 Quite Low
dexamethasone 46 5.00 Very Low Very Low Very Low
peripheral neuropathy 12 5.00 Very Low Very Low Very Low
cva 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 439 100.00 Very High Very High Very High
Colon Cancer 15 99.84 Very High Very High Very High
Death 26 98.00 Very High Very High Very High
Fibrosis 8 97.04 Very High Very High Very High
Pancreatitis 14 95.52 Very High Very High Very High
INFLAMMATION 14 95.36 Very High Very High Very High
Shigella Infection 9 93.92 High High
Cytomegalovirus Infection 1 92.96 High High
Stress 6 91.56 High High
Cancer 31 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They also neo-express NFkappaB subunits, survivin, and cIAP1.
Gene_expression (express) of cIAP1
1) Confidence 0.63 Published 2006 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 17867593 Disease Relevance 0.91 Pain Relevance 0.55
We conclude that cAMP can induce c-IAP2 expression in colon cancer cells through CREB phosphorylation and CRE-dependent transcription in a manner that involves activation of ERK1/2 and p38 MAPK.
Gene_expression (expression) of c-IAP2 in colon associated with colon cancer
2) Confidence 0.54 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.85 Pain Relevance 0.09
In this study, we used T84 human colon cancer cells to define the pathway by which increases in cAMP induce c-IAP2 expression.
Gene_expression (expression) of c-IAP2 in T84 associated with colon cancer
3) Confidence 0.54 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.78 Pain Relevance 0.14
Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.
Gene_expression (expression) of c-IAP2 associated with agonist
4) Confidence 0.54 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.80 Pain Relevance 0.14
The NFkappaB regulated proteins IkappaBalpha, survivin, and cIAP1 were found in corresponding sites, again, at highest levels in islets surrounded by fibrosis.
Gene_expression (found) of cIAP1 associated with fibrosis
5) Confidence 0.49 Published 2006 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 17867593 Disease Relevance 1.14 Pain Relevance 0.59
Also in support of this hypothesis, there was no change in expression of JUN, BIRC2/cIAP1, TRAF2, or NFKB2.
Gene_expression (expression) of cIAP1
6) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.41 Pain Relevance 0
Also in support of this hypothesis, there was no change in expression of JUN, BIRC2/cIAP1, TRAF2, or NFKB2.
Gene_expression (expression) of BIRC2
7) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.41 Pain Relevance 0
In addition, cIAP1 ubiquitinates NEMO in response to TNF-?
Gene_expression (ubiquitinates) of cIAP1
8) Confidence 0.36 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.23 Pain Relevance 0
in normal donors [23] and/or by increasing in vivo CD56+ NK cell proliferation [24]; and (e) interfere with intracellular growth signalling by down-regulating the constitutive activity of nuclear factor kappa B (NFkB) (i.e., through the block of insulin-like growth factor-1) [25, 26] as well as the expression of cellular inhibitor of apoptosis protein-2 (cIAP-2) and FLICE inhibitory protein (FLIP), two well known inhibitors of apoptosis [17] (Fig. 1).
Gene_expression (expression) of apoptosis protein-2 in NK cell associated with apoptosis
9) Confidence 0.13 Published 2007 Journal Clin Exp Med Section Body Doc Link PMC2779346 Disease Relevance 1.05 Pain Relevance 0.08
We developed a gene gun method for the transfer of human agouti signalling protein (ASP) cDNA to alter rat skin colour in vivo.
Gene_expression (transfer) of signalling protein in skin
10) Confidence 0.01 Published 2004 Journal Gene Ther. Section Abstract Doc Link 15164092 Disease Relevance 0.18 Pain Relevance 0

General Comments

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