INT117919

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.72
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BIRC2) intracellular (BIRC2) cytoplasm (BIRC2)
Anatomy Link Frequency
colon 3
BIRC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 95.40 Very High Very High Very High
agonist 3 79.32 Quite High
cytokine 5 59.84 Quite High
chemokine 11 22.64 Low Low
Pain 2 13.52 Low Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 17 100.00 Very High Very High Very High
Colon Cancer 15 99.44 Very High Very High Very High
Infection 68 98.56 Very High Very High Very High
Influenza Virus Infection 2 97.12 Very High Very High Very High
INFLAMMATION 4 95.20 Very High Very High Very High
Dengue 126 94.64 High High
Sarcoma 1 80.84 Quite High
Stress 3 54.16 Quite High
Disease 11 53.28 Quite High
Viremia 1 50.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently reported that cAMP suppresses apoptosis in colon cancer cells and induces cellular inhibitor of apoptosis protein-2 (c-IAP2) via a cAMP-responsive element (CRE), suggesting a mechanism for chemoprevention of colon cancer by non-steroidal anti-inflammatory drugs.
Negative_regulation (inhibitor) of apoptosis protein-2 in colon associated with inflammation, colon cancer, cinod and apoptosis
1) Confidence 0.30 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.80 Pain Relevance 0.13
We recently reported that cAMP suppresses apoptosis in colon cancer cells and induces cellular inhibitor of apoptosis protein-2 (c-IAP2) via a cAMP-responsive element (CRE), suggesting a mechanism for chemoprevention of colon cancer by non-steroidal anti-inflammatory drugs.
Negative_regulation (inhibitor) of c-IAP2 in colon associated with inflammation, colon cancer, cinod and apoptosis
2) Confidence 0.30 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.80 Pain Relevance 0.13
Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK.
Negative_regulation (inhibitor) of apoptosis protein-2 in colon associated with colon cancer and apoptosis
3) Confidence 0.30 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 15078890 Disease Relevance 0.89 Pain Relevance 0.13
, galectin-9, phospholipid scramblase 1 and human inhibitor of apoptosis-1 (IAP1) were shown to be upregulated upon infection [12].
Negative_regulation (inhibitor) of IAP1 associated with apoptosis and infection
4) Confidence 0.00 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.23 Pain Relevance 0.06

General Comments

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