INT117922

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Context Info
Confidence 0.08
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.81
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

USHBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 1 99.76 Very High Very High Very High
cINOD 1 92.52 High High
Action potential 1 36.40 Quite Low
tetrodotoxin 1 33.68 Quite Low
Disease Link Frequency Relevance Heat
Colon Cancer 5 94.40 High High
INFLAMMATION 1 92.28 High High
Apoptosis 5 86.28 High High
Stress 1 54.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with several different cAMP agonists stimulated phosphorylation of CRE-binding protein (CREB) and activated expression of c-IAP2 in a CREB-dependent manner.
Phosphorylation (phosphorylation) of CRE-binding protein associated with agonist
1) Confidence 0.08 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.81 Pain Relevance 0.14
In cell culture systems, the extracellular-regulated kinase (ERK) and ribosomal S6 kinase (RSK) couple synaptic signals to CRE-mediated gene expression by modulating CRE-binding protein (CREB) phosphorylation.
Phosphorylation (phosphorylation) of CRE-binding protein
2) Confidence 0.00 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15389611 Disease Relevance 0 Pain Relevance 0

General Comments

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