INT117923

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 2.50
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BIRC2) intracellular (BIRC2) cytoplasm (BIRC2)
Anatomy Link Frequency
colon 2
BIRC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 95.40 Very High Very High Very High
agonist 3 81.44 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 15 100.00 Very High Very High Very High
Colon Cancer 15 99.78 Very High Very High Very High
INFLAMMATION 3 95.20 Very High Very High Very High
Stress 3 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblots and transcriptional reporter assays using specific inhibitors, as well as expression of constitutively active forms of MEK1 and MKK3, showed that c-IAP2 induction by cAMP is regulated predominantly through ERK1/2 and p38 MAPK and suggested involvement of p90 ribosomal protein S6 kinase and mitogen and stress response kinase-1 as well.
Positive_regulation (induction) of c-IAP2 associated with stress
1) Confidence 0.48 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.89 Pain Relevance 0.12
We recently reported that cAMP suppresses apoptosis in colon cancer cells and induces cellular inhibitor of apoptosis protein-2 (c-IAP2) via a cAMP-responsive element (CRE), suggesting a mechanism for chemoprevention of colon cancer by non-steroidal anti-inflammatory drugs.
Positive_regulation (induces) of apoptosis protein-2 in colon associated with inflammation, colon cancer, cinod and apoptosis
2) Confidence 0.35 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.80 Pain Relevance 0.13
We recently reported that cAMP suppresses apoptosis in colon cancer cells and induces cellular inhibitor of apoptosis protein-2 (c-IAP2) via a cAMP-responsive element (CRE), suggesting a mechanism for chemoprevention of colon cancer by non-steroidal anti-inflammatory drugs.
Positive_regulation (induces) of c-IAP2 in colon associated with inflammation, colon cancer, cinod and apoptosis
3) Confidence 0.35 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15078890 Disease Relevance 0.80 Pain Relevance 0.13

General Comments

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