INT11793

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 78
Total Number 78
Disease Relevance 19.63
Pain Relevance 12.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
reticulum 9
plasma 4
lung 2
neutrophil 2
neuronal 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 41 100.00 Very High Very High Very High
Somatostatin 8 100.00 Very High Very High Very High
Action potential 91 99.92 Very High Very High Very High
Clonidine 3 99.90 Very High Very High Very High
Enkephalin 7 99.82 Very High Very High Very High
antagonist 213 99.68 Very High Very High Very High
dexamethasone 131 99.56 Very High Very High Very High
GABAergic 10 99.44 Very High Very High Very High
depression 38 99.36 Very High Very High Very High
addiction 69 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 271 99.92 Very High Very High Very High
Stress 119 99.56 Very High Very High Very High
Cv Unclassified Under Development 26 99.36 Very High Very High Very High
Hypoxia 47 98.88 Very High Very High Very High
Death 119 98.62 Very High Very High Very High
INFLAMMATION 305 98.44 Very High Very High Very High
Cancer 397 97.98 Very High Very High Very High
Pressure And Volume Under Development 65 97.96 Very High Very High Very High
Depression 38 97.80 Very High Very High Very High
Targeted Disruption 67 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study tests the hypothesis that inhibiting nuclear Ca2+ -influx by pretreatment with clonidine, an inhibitor of high affinity Ca2+ -ATPase, will prevent the hypoxia-induced increase in caspase-9 and caspase-3 activity in the cerebral cortex of newborn piglets.
Negative_regulation (inhibitor) of Ca2 in cerebral cortex associated with hypoxia, cerebral cortex and clonidine
1) Confidence 0.57 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17268855 Disease Relevance 0.67 Pain Relevance 0.31
These results indicate that inhibition of T-type Ca2+ channels is responsible for inhibition of aldosterone production in NCI-H295R cells.
Negative_regulation (inhibition) of Ca2 in NCI-H295R
2) Confidence 0.42 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18331727 Disease Relevance 0.06 Pain Relevance 0.21
CE has been shown to induce apoptosis in various cancer cells lines through a COX2-independent mechanism that seems to involve inactivation of protein kinase Akt and inhibition of endoplasmic reticulum (ER) Ca2+ ATPase.
Negative_regulation (inhibition) of Ca2 in reticulum associated with cancer, cox2 and apoptosis
3) Confidence 0.42 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16467190 Disease Relevance 0.53 Pain Relevance 0.50
Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-n-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na+-Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in stably transfected cells.
Negative_regulation (inhibitor) of Ca2
4) Confidence 0.42 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 19602550 Disease Relevance 0 Pain Relevance 0.06
Results showed that in the control group, E-Ca2+, IF, MCV and F-Hb were gradually increased and Ca2+-Mg2+-ATPase and Na+-K+-ATPase activities were decreased.
Negative_regulation (decreased) of Ca2
5) Confidence 0.42 Published 2004 Journal J. Huazhong Univ. Sci. Technol. Med. Sci. Section Abstract Doc Link 15315180 Disease Relevance 0.22 Pain Relevance 0.12
On the other hand, glutamate uptake was decreased by trifluoperazine, a calmodulin antagonist, and KN-62, an inhibitor of Ca2+/calmodulin-dependent protein kinase II, implying that intrasynaptosomal Ca2+ might also have a role in the uptake of glutamate, and Ca2+/calmodulin-dependent processes, such as Ca2+/calmodulin-dependent protein kinase II, might be involved in the modulation of glutamate transporter activity.
Negative_regulation (inhibitor) of Ca2 associated with glutamate and antagonist
6) Confidence 0.42 Published 1999 Journal J Neural Transm Section Abstract Doc Link 10392534 Disease Relevance 0 Pain Relevance 0.52
Diclofenac significantly suppressed SH-SY5Y cell death induced by two types of ER-stress-inducing agents: thapsigargin, an inhibitor of Ca2+-ATPase on the endoplasmic reticulum membrane, and tunicamycin, a glycosylation blocker.
Negative_regulation (inhibitor) of Ca2 in SH-SY5Y associated with stress, diclofenac and death
7) Confidence 0.42 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.72 Pain Relevance 0.89
In GH3 cells expressing only micro receptors (GH3MOR cells), the micro receptor-specific ligand [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO) inhibited spontaneous Ca 2+ signaling by the inhibition of voltage-gated Ca 2+ channels, activation of inward-rectifying K+ channels, and inhibition of adenylyl cyclase.
Negative_regulation (inhibited) of Ca 2 in GH3 associated with enkephalin
8) Confidence 0.41 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12488540 Disease Relevance 0.07 Pain Relevance 0.27
The inhibitory effect of somatostatin on Ca 2+ signaling was not different in GH3MORDOR versus GH3MOR cells.
Negative_regulation (effect) of Ca 2 associated with somatostatin
9) Confidence 0.41 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12488540 Disease Relevance 0.08 Pain Relevance 0.38
The results are consistent with the hypothesis that suppression of Ca2+ signals can be considered as a common denominator of the effects of xenon on the cell cycle and on the neuronal system during anesthesia.
Negative_regulation (suppression) of Ca2 in neuronal associated with anesthesia
10) Confidence 0.38 Published 1999 Journal Pflugers Arch. Section Abstract Doc Link 10087152 Disease Relevance 0 Pain Relevance 0.12
In Ca2+-free medium pretreatment with 1 microM thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+ pump, abolished 100 microM fluoxetine-induced Ca2+ release.
Negative_regulation (inhibitor) of Ca2 in reticulum associated with fluoxetine
11) Confidence 0.38 Published 2001 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11191831 Disease Relevance 0 Pain Relevance 0.59
Decrease of vasomotion observed during midazolam infusion is probably due to the benzodiazepine effects on intracellular calcium concentration: inhibition of Ca2+ influx and decrease of Ca2+ release from sarcoplasmic reticulum [33].
Negative_regulation (inhibition) of Ca2 in reticulum associated with versed
12) Confidence 0.37 Published 2006 Journal Crit Care Section Body Doc Link PMC1794492 Disease Relevance 0.17 Pain Relevance 0.26
Indo-1 measurements of free intracellular Ca2+ concentrations ([Ca2+]i, 169 +/- 14 nM and 141 +/- 8 nM in short-term culture vs. 149 +/- 5 nM in cells cultured for 3-6 days) showed that decidual cells have spontaneous transient fluctuations of [Ca2+]i and that [Ca2+]i was decreased by Ca2+ channel blockers.
Negative_regulation (decreased) of Ca2
13) Confidence 0.37 Published 1992 Journal Endocrinology Section Abstract Doc Link 1597150 Disease Relevance 0 Pain Relevance 0.23
In many cell types, depletion of intracellular Ca2+ stores results in the opening of SOCE in the plasma membrane [16].
Negative_regulation (depletion) of Ca2 in plasma
14) Confidence 0.36 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.21 Pain Relevance 0.10
Therefore we propose that the resultant decrease of Ca2+ in ER after Echinacea treatment would in turn activate the plasma membrane SOCE through a mechanism that involves STIM1.
Negative_regulation (decrease) of Ca2 in plasma
15) Confidence 0.36 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.17 Pain Relevance 0.04
Depletion of the Ca2+ store by repeated stimulation of single muscle cells in Ca2+-free medium with IP3, acetylcholine or CCK-8 separately resulted in loss of contractile response to all three agents; the response was restored by re-exposure of the muscle cell to cytosol-like perfusate (Ca2+ 180 nM).
Negative_regulation (Depletion) of Ca2 in muscle cell
16) Confidence 0.36 Published 1988 Journal Mol. Cell. Biochem. Section Abstract Doc Link 3263564 Disease Relevance 0 Pain Relevance 0.23
The intracellular Ca2+ store could be depleted by repeated stimulation with all agonists in Ca2+-free medium or in the presence of D600 resulting in loss of contractile response; response was restored by re-exposure of the cells to Ca2+.
Negative_regulation (depleted) of Ca2 associated with agonist
17) Confidence 0.36 Published 1988 Journal Mol. Cell. Biochem. Section Abstract Doc Link 3263564 Disease Relevance 0 Pain Relevance 0.30
Later, Valentin et al. [4] determinated that Ca2+ influx plays a primordial role in plasma membrane translocation of Rac (Fig. 1) by demonstrating that extracellular Ca2+ deprivation abolishes Rac membrane recruitment stimulated by fMLF in differentiated HL-60 cells.
Negative_regulation (deprivation) of Ca2 in HL-60
18) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.07 Pain Relevance 0.05
Further, Ca2+ store depletion stimulated rapid STIM1 surface expression and its association with TRPC1.
Negative_regulation (depletion) of Ca2
19) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Dissection of the mechanism linking Ca2+ store depletion to SOCs channel activation as well as the nature of these Ca2+ channels might help to characterize the regulation of superoxide anion release and serve as targets for pharmacological drug development in inflammatory diseases.



Negative_regulation (depletion) of Ca2 associated with inflammation and disease
20) Confidence 0.30 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.34 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox