INT117933

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Context Info
Confidence 0.38
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.62
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Cd38) plasma membrane (Cd38) nucleus (Cd38)
Anatomy Link Frequency
reticulum 2
neutrophils 2
Cd38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 13 96.04 Very High Very High Very High
intrathecal 5 90.92 High High
agonist 8 90.08 High High
Dorsal horn 3 89.88 High High
Glutamate 8 88.04 High High
long-term potentiation 68 84.32 Quite High
nMDA receptor 3 83.40 Quite High
Angina 2 78.08 Quite High
Inflammatory response 2 75.40 Quite High
Inflammation 3 75.36 Quite High
Disease Link Frequency Relevance Heat
Chronic Lymphoid Leukemia 41 99.84 Very High Very High Very High
Hypoxia 146 99.36 Very High Very High Very High
Cv General 3 Under Development 2 78.08 Quite High
INFLAMMATION 3 75.04 Quite High
Ganglion Cysts 19 68.88 Quite High
Pain 8 62.72 Quite High
Cv General 2 Under Development 2 62.00 Quite High
Staphylococcus Infection 1 53.20 Quite High
Hemorrhage 3 52.48 Quite High
Erythema 1 51.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days.
Positive_regulation (increase) of Gene_expression (produces) of CD38 in neutrophils
1) Confidence 0.38 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080559 Disease Relevance 0.30 Pain Relevance 0.26
Importantly, the RyR is a down-stream target for the NO-PKG-cADPR signaling pathway and PKG-induced production of cADPR synergistically with intracellular Ca2+ activates RyRs [29].
Positive_regulation (induced) of Gene_expression (production) of cADPR
2) Confidence 0.12 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.25 Pain Relevance 0.88
Baseline characteristics among the responding patients included elevated CD38 expression in CLL cells in 3 of the 5 previously untreated patients and 6 of the 13 previously treated patients (Mavromatis et al 2006).
Positive_regulation (elevated) of Gene_expression (expression) of CD38 associated with chronic lymphoid leukemia
3) Confidence 0.07 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.43 Pain Relevance 0.05
In pulmonary vascular smooth muscle, it has been suggested that hypoxia induced increase in NADH might stimulate cyclic-ADP-ribose (cADPR) production (Dipp and Evans 2001; Evans and Dipp 2002) and thus evoke Ca2+ release from the sarcoplasmic/endoplasmic reticulum.
Spec (might) Positive_regulation (stimulate) of Gene_expression (production) of cADPR in reticulum associated with hypoxia
4) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.65 Pain Relevance 0.03

General Comments

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