INT117934

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.50
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Cd38) plasma membrane (Cd38) nucleus (Cd38)
Anatomy Link Frequency
reticulum 2
plasma cells 1
artery 1
vein 1
neutrophils 1
Cd38 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 13 95.72 Very High Very High Very High
intrathecal 5 90.60 High High
agonist 8 90.08 High High
Dorsal horn 3 89.56 High High
Central nervous system 7 87.92 High High
Glutamate 8 87.72 High High
Spinal cord 19 87.00 High High
imagery 9 85.20 High High
long-term potentiation 68 84.32 Quite High
headache 2 83.76 Quite High
Disease Link Frequency Relevance Heat
Cancer 22 99.86 Very High Very High Very High
Chronic Lymphoid Leukemia 41 99.84 Very High Very High Very High
Malignant Neoplastic Disease 8 99.84 Very High Very High Very High
Multiple Myeloma 56 99.66 Very High Very High Very High
Lymphatic System Cancer 24 99.34 Very High Very High Very High
Plasmacytoma 16 99.08 Very High Very High Very High
Hypoxia 292 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 5 98.40 Very High Very High Very High
Skin Cancer 4 94.40 High High
Congenital Anomalies 2 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western immunoblot analysis revealed that CD38 is expressed in both artery and vein.
Gene_expression (expressed) of CD38 in vein
1) Confidence 0.68 Published 2006 Journal Neuroscience Section Abstract Doc Link 16580146 Disease Relevance 0 Pain Relevance 0.12
We found that coronary angioplasty with stent implantation produces an increase in the cell surface expression of CD11b/CD18 in neutrophils and CD38 in monocytes, following a similar time-course with a peak after 24 h, returning to basal levels after 48 h and a second peak after 7 days.
Gene_expression (produces) of CD38 in neutrophils
2) Confidence 0.51 Published 2004 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15080559 Disease Relevance 0.30 Pain Relevance 0.26
Western immunoblot analysis revealed that CD38 is expressed in both artery and vein.
Gene_expression (expressed) of CD38 in artery
3) Confidence 0.23 Published 2006 Journal Neuroscience Section Abstract Doc Link 16580146 Disease Relevance 0 Pain Relevance 0.12
Importantly, the RyR is a down-stream target for the NO-PKG-cADPR signaling pathway and PKG-induced production of cADPR synergistically with intracellular Ca2+ activates RyRs [29].
Gene_expression (production) of cADPR
4) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.25 Pain Relevance 0.88
The best method to differentiate EMP from other types of plasma cell tumors or lymphomas is that the EMP is positive for CD38 and monoclonal cytoplasmic light chain expression of malignant plasma cells obtained by surgical or needle biopsy.
Gene_expression (expression) of CD38 in plasma cells associated with malignant neoplastic disease, plasmacytoma, lymphatic system cancer and multiple myeloma
5) Confidence 0.11 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2186338 Disease Relevance 1.84 Pain Relevance 0.03
Tumor cells stained positively for CD10, CD22, CD38 and HLA-DR.
Gene_expression (stained) of CD38 associated with cancer
6) Confidence 0.09 Published 2004 Journal Acta Haematol. Section Abstract Doc Link 15564734 Disease Relevance 1.41 Pain Relevance 0.31
Baseline characteristics among the responding patients included elevated CD38 expression in CLL cells in 3 of the 5 previously untreated patients and 6 of the 13 previously treated patients (Mavromatis et al 2006).
Gene_expression (expression) of CD38 associated with chronic lymphoid leukemia
7) Confidence 0.08 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.42 Pain Relevance 0.05
They were CD5, CD10, CD38 and CD138 negative (figure 6).
Neg (negative) Gene_expression (negative) of CD38
8) Confidence 0.08 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2944189 Disease Relevance 0.25 Pain Relevance 0.06
Immunohistochemistry revealed positive CD38 and negative CD20, CD19, CD56 and CD45 (Fig 2).
Neg (negative) Gene_expression (negative) of CD38
9) Confidence 0.05 Published 2008 Journal Cases J Section Body Doc Link PMC2566563 Disease Relevance 0.60 Pain Relevance 0.09
A model that has been advanced to explain hypoxic pulmonary vasoconstriction suggests that hypoxia-induced increase NADH could stimulate cyclic-ADP-ribose (cADPR) production (Dipp and Evans 2001; Evans and Dipp 2002). cADPR promotes Ca2+ release from the endoplasmic reticulum via ryanodine receptors (Galione 1993; Tanaka and Tashjian 1995; Thorn et al. 1994).
Gene_expression (production) of cADPR in reticulum associated with hypoxia and increased venous pressure under development
10) Confidence 0.04 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.79 Pain Relevance 0
In pulmonary vascular smooth muscle, it has been suggested that hypoxia induced increase in NADH might stimulate cyclic-ADP-ribose (cADPR) production (Dipp and Evans 2001; Evans and Dipp 2002) and thus evoke Ca2+ release from the sarcoplasmic/endoplasmic reticulum.
Gene_expression (production) of cADPR in reticulum associated with hypoxia
11) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.64 Pain Relevance 0.03

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