INT117935

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.63
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SRA1) cell proliferation (SRA1) nucleus (SRA1)
DNA binding (SRA1) cytoplasm (SRA1)
Anatomy Link Frequency
lungs 2
blood 1
HL-60 1
SRA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.76 Very High Very High Very High
fibrosis 138 99.64 Very High Very High Very High
Inflammation 22 5.00 Very Low Very Low Very Low
agonist 12 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Idiopathic Pulmonary Fibrosis 138 99.64 Very High Very High Very High
Pulmonary Disease 128 98.88 Very High Very High Very High
Cancer 32 93.28 High High
Nicotine Addiction 18 84.56 Quite High
Fibrosis 12 79.44 Quite High
Disease 46 78.12 Quite High
Neuroblastoma 6 75.20 Quite High
Apoptosis 46 70.56 Quite High
Injury 4 52.88 Quite High
Stress 30 28.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that the blockade of SRA with tetrodotoxin (TTX), or the blockade of axonal transport with colchicine, both reversed the normal mismatch between retinal BDNF mRNA and protein.
Negative_regulation (blockade) of SRA associated with tetrodotoxin
1) Confidence 0.11 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15080885 Disease Relevance 0 Pain Relevance 0.10
in HNE-treated HL-60 cells there is a decrease in Myc binding complexes and an
Negative_regulation (decrease) of complexes in HL-60
2) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.20 Pain Relevance 0
expression can result in a reduced activity of cyclin/CDK complexes which
Negative_regulation (reduced) of complexes
3) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.15 Pain Relevance 0
All together, these synergistic functions of NRP1 in reducing anti-angiogenic complexes and promoting pro-angiogenic complexes, were in tune with computational predictions from our previous studies in the absence of sVEGFR1 [54].

3.2.

Negative_regulation (reducing) of complexes
4) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
Distribution analysis in the blood showed that the number of sVEGFR1-VEGF complexes reduced proportionally to free VEGF (sVEGFR1-complexed fraction of total VEGF was consistent within 2%) while the fractional occupancy of sVEGFR1 dropped from 19% to 2% over the 100-fold variation in kCL.
Negative_regulation (number) of complexes in blood
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
monomers and complexes were reduced/lost in IPF but not in the COPD lungs when compared to control lung.
Negative_regulation (reduced) of complexes in lung associated with fibrosis and pulmonary disease
6) Confidence 0.00 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2949726 Disease Relevance 1.18 Pain Relevance 0.31
Decline of Hb complexes and monomers in the IPF but not in the COPD lungs
Negative_regulation (Decline) of complexes in lungs associated with fibrosis and pulmonary disease
7) Confidence 0.00 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 1.11 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox