INT117936

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 9.37
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
anatomic regions 2
livers 2
retina 2
ACC 2
hippocampus 2
Egr1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 25 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
Anterior cingulate cortex 5 99.68 Very High Very High Very High
Inflammation 31 99.66 Very High Very High Very High
Eae 24 99.60 Very High Very High Very High
Pain 10 99.40 Very High Very High Very High
nociceptor 3 99.40 Very High Very High Very High
GABAergic 11 98.32 Very High Very High Very High
Hippocampus 25 97.92 Very High Very High Very High
fluoxetine 8 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 28 99.66 Very High Very High Very High
Stress 53 99.44 Very High Very High Very High
Sprains And Strains 17 98.64 Very High Very High Very High
Lung Cancer 125 98.16 Very High Very High Very High
Melanoma 102 95.92 Very High Very High Very High
Targeted Disruption 42 95.80 Very High Very High Very High
Salivary Gland Disease 36 95.28 Very High Very High Very High
Shock 44 93.92 High High
Inflammatory Pain 4 92.08 High High
Myopia 52 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, Egr-1 expression in the retina was strongly regulated by light.
Regulation (regulated) of Gene_expression (expression) of Egr-1 in retina
1) Confidence 0.60 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.15 Pain Relevance 0
In contrast to the strain-independent effect of early life stress on GR expression, however, changes in egr-1 expression occurred only in Balb/c mice, and unlike the biphasic developmental changes in GR mRNA expression, egr-1 mRNA was decreased throughout postnatal development.
Regulation (changes) of Gene_expression (expression) of egr-1 associated with stress and sprains and strains
2) Confidence 0.60 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.14 Pain Relevance 0.16
Thus, in Balb/c mice, changes in GR and egr-1 expression can independently contribute to the phenotypes resulting from early life stress exposure.
Regulation (changes) of Gene_expression (expression) of egr-1 associated with stress
3) Confidence 0.60 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.92 Pain Relevance 0.19
These findings illustrate that the impact of early life stress on gene expression changes is modulated by the genetic background and that the persistent changes in GR and egr-1 expression that arise early during postnatal developmental are reversible by chronic fluoxetine treatment during adolescence and adulthood.
Regulation (changes) of Gene_expression (expression) of egr-1 associated with stress and fluoxetine
4) Confidence 0.60 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 0.79 Pain Relevance 0.20
Western blotting analyses were conducted to assess constitutive and regulated levels of Egr1, Egr2 and Egr3 in the dentate gyrus and CA1 of the hippocampus from WT, HT and cKO mice (n?
Regulation (regulated) of Gene_expression (levels) of Egr1 in hippocampus associated with hippocampus
5) Confidence 0.45 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0 Pain Relevance 0.05
The reduction of image intensity therefore had a higher impact on Egr-1 expression level than did the changes in image contrast and spatial frequency content that were induced by diffuser wear.
Regulation (impact) of Gene_expression (expression) of Egr-1
6) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
The impact of diffuser and ND filter treatment on Egr-1 and cFos mRNA expression was analyzed over time and also compared to a group of untreated control animals (Figure 3).
Spec (analyzed) Regulation (impact) of Gene_expression (expression) of Egr-1
7) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.07 Pain Relevance 0
After overlapping the associated genes of each TF, it can be seen that the altered activities of the three TFs (RunX1, MLXIPL and TRIM30) can be potentially responsible for 83% of the up-regulated mRNAs in saliva (Fig. 4G) whereas the collective altered activities of Egr1, Tbx1 and Nr1d1 can potentially account for 63% of the down-regulated expression of salivary mRNAs (Fig. 4H).


Regulation (regulated) of Gene_expression (expression) of Egr1 in saliva
8) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.93 Pain Relevance 0.19
In situ hybridization showed that after injecting muscimol in the D2R-/- mice, the expression of enkephalin and immediate early gene, NGFI-A, was closely regulated with the locomotor activity regulated by GABAergic stimulation.
Regulation (regulated) of Gene_expression (expression) of NGFI-A associated with gabaergic, eae and enkephalin
9) Confidence 0.44 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15080900 Disease Relevance 0.16 Pain Relevance 0.69
Moreover, there was no consistent overlap of anatomic regions affected by decreased GR and egr-1 protein expression.
Regulation (affected) of Gene_expression (expression) of egr-1 in anatomic regions
10) Confidence 0.44 Published 2010 Journal Dev. Neurosci. Section Abstract Doc Link 20453467 Disease Relevance 1.03 Pain Relevance 0.19
Nonetheless, a subset of immediate-early genes implicated in the control of cell cycle progression, such as c-Fos and Egr1, exhibited an impaired activation in c-Met mutant livers, particularly at the later time points of liver regeneration (Figure S3).
Regulation (control) of Gene_expression (progression) of Egr1 in livers
11) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.04
Furthermore, LPS induced the expression of Egr-1 that cooperated with NF-kappaB in the up-regulation of COX-2 and mPGES-1.
Regulation (regulation) of Gene_expression (expression) of Egr-1
12) Confidence 0.30 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.29 Pain Relevance 0.15
In addition, inflammation triggered an up-regulation of Egr1 expression in the ACC of wild-type mice.
Regulation (regulation) of Gene_expression (expression) of Egr1 in ACC associated with inflammation and anterior cingulate cortex
13) Confidence 0.27 Published 2005 Journal J Pain Section Abstract Doc Link 15629414 Disease Relevance 1.37 Pain Relevance 0.76
This suggests that in the absence of Egr2 there is neither compensatory regulation nor a linked detrimental effect on expression of Egr1 and Egr3.
Neg (nor) Regulation (effect) of Gene_expression (expression) of Egr1
14) Confidence 0.27 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.40 Pain Relevance 0.04
The influence of form deprivation on Egr-1 mRNA expression [21] could be confirmed and strengthened in the present study, since Egr-1 expression was decreased in the diffuser-treated eyes at all time points even though the intensity of the retinal images was matched in both eyes.
Regulation (influence) of Gene_expression (expression) of Egr-1 mRNA in eyes
15) Confidence 0.26 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.18 Pain Relevance 0
The relative fold changes of TF expression such as Egr1 and Nr1d1 are different between mRNA levels and protein levels, which may reflect translational modification or proteasomal degradation [25].
Regulation (changes) of Gene_expression (expression) of Egr1
16) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691577 Disease Relevance 0.87 Pain Relevance 0.07
Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons.
Regulation (regulate) of Gene_expression (expression) of zif268 in spinal associated with nociceptor and long-term potentiation
17) Confidence 0.19 Published 2006 Journal Eur. J. Neurosci. Section Title Doc Link 16930406 Disease Relevance 0.21 Pain Relevance 1.17
Moreover, expression of SKIL, a negative regulator of TGF-beta signaling [28], and EGR1, a potent transcription factor with a dual role in tumorigenesis [29], was modulated upon TUSC2 introduction in 4 out of 5 tested MPM cell lines.
Regulation (modulated) of Gene_expression (expression) of EGR1 associated with lung cancer
18) Confidence 0.18 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 0.84 Pain Relevance 0
This results in the opposite regulation of the activity of cAMP-dependent protein kinase involved in modulating the activity of numerous phosphoproteins and transcription factors, which control the expression of immediate early genes, such as c-fos and zif-268, leading to long-term adaptive responses [8,10].
Regulation (control) of Gene_expression (expression) of zif-268
19) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0 Pain Relevance 0.55

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