INT11795

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Context Info
Confidence 0.28
First Reported 1982
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 33
Total Number 36
Disease Relevance 6.51
Pain Relevance 14.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Helt) nucleus (Helt) DNA binding (Helt)
Anatomy Link Frequency
neurons 12
medulla 2
dentate gyrus 1
stellate cells 1
DMNV 1
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 262 100.00 Very High Very High Very High
amygdala 176 100.00 Very High Very High Very High
opiate 8 99.98 Very High Very High Very High
electroacupuncture 48 99.82 Very High Very High Very High
Somatostatin 3 99.76 Very High Very High Very High
Central nervous system 17 99.54 Very High Very High Very High
Thalamus 13 99.48 Very High Very High Very High
cerebral cortex 8 99.48 Very High Very High Very High
Pyramidal cell 128 99.32 Very High Very High Very High
analgesia 12 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Respiratory Failure 1 99.44 Very High Very High Very High
Sleep Disorders 202 99.04 Very High Very High Very High
Drug Induced Neurotoxicity 3 98.34 Very High Very High Very High
Cognitive Disorder 33 98.12 Very High Very High Very High
Convulsion 9 97.92 Very High Very High Very High
Neuropathic Pain 1 97.36 Very High Very High Very High
Syndrome 12 96.32 Very High Very High Very High
Epilepsy 10 95.52 Very High Very High Very High
Amblyopia 10 94.52 High High
Shock 3 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Application of the selective micro-antagonist CTOP abolished the fentanyl-mediated inhibition of GABAergic IPSCs.
Negative_regulation (inhibition) of GABAergic associated with gabaergic and antagonist
1) Confidence 0.28 Published 2004 Journal Brain Res. Section Abstract Doc Link 15064141 Disease Relevance 0.07 Pain Relevance 0.54
Theses and related findings support the hypothesis that morphine enhances the seizure-linked neurotoxicity of KA by an opiate specific action at certain limbic receptor sites where opiates suppress GABAergic activity, thereby lowering the threshold for propagation of seizure activity in limbic circuits.
Negative_regulation (suppress) of GABAergic associated with drug induced neurotoxicity, convulsion, gabaergic, opiate and morphine
2) Confidence 0.25 Published 1982 Journal Life Sci. Section Abstract Doc Link 6289030 Disease Relevance 0.71 Pain Relevance 0.68
Interneurons in layer III did not appear to be dormant; therefore, we tested whether loss of GABAergic synapses might underlie hyperexcitability of layer II stellate cells.
Negative_regulation (loss) of GABAergic in stellate cells associated with gabaergic and hyperexcitability
3) Confidence 0.25 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16641241 Disease Relevance 0.46 Pain Relevance 0.59
However, it is unknown how proBDNF and mature BDNF affect the excitability of GABAergic interneurons and thereby regulate GABAergic inhibition.
Negative_regulation (inhibition) of GABAergic in interneurons associated with gabaergic
4) Confidence 0.17 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19812317 Disease Relevance 0 Pain Relevance 0.34
Single electroacupuncture (EA) exposure (10 Hz, 1 volt, 15 min) to long-term (15 consecutive days) diazepam (5 mg/kg/day, i.p.) treated adult male albino rats (120-140 g) potentiated the long-term diazepam-induced increase of GABAergic activity in thalamus (Th) but the long-term diazepam-induced inhibition of GABAergic activity in cerebral cortex (CC) and spinal cord (SC) was disinhibited under similar condition of treatment.
Negative_regulation (inhibition) of GABAergic in thalamus associated with gabaergic, thalamus, cerebral cortex, electroacupuncture and spinal cord
5) Confidence 0.14 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 1598023 Disease Relevance 0 Pain Relevance 1.24
Single EA exposure alone, however, inhibited GABAergic activity in Th and pons-medulla (PM) with the development of EAA.
Negative_regulation (inhibited) of GABAergic in medulla associated with medulla, gabaergic, thalamus, electroacupuncture and analgesia
6) Confidence 0.14 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 1598023 Disease Relevance 0 Pain Relevance 1.64
We have recently shown that gabapentin generates protein kinase A (PKA)-dependent presynaptic inhibition of GABAergic synaptic transmission in locus coeruleus (LC) neurons only under neuropathic states.
Negative_regulation (inhibition) of GABAergic in neurons associated with locus ceruleus, gabaergic, neuropathic pain and gabapentin
7) Confidence 0.09 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19498268 Disease Relevance 0.32 Pain Relevance 0.85
Single-dose diazepam (5 mg/kg i.p.) which increases central GABAergic activity alone normalizes the 6 multiple electroacupuncture (EA) (10 Hz, 1 volt, 10 min/day)-induced inhibition of GABAergic activity in Th and PM and thus reduces the EAA of adult male albino rats (120 +/- 10 g).
Negative_regulation (inhibition) of GABAergic associated with gabaergic and electroacupuncture
8) Confidence 0.05 Published 1991 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2051841 Disease Relevance 0 Pain Relevance 0.63
On the contrary, single diazepam (5 mg/kg, i.p.) treatment to 15 multiple EA-(10 Hz, 1 volt, 10 min/day) exposed rats normalizes the 15 multiple EA-induced increase in thalamic GABAergic activity and fails to alter inhibition of GABAergic activity in CC and SC of 15 multiple EA-exposed rats.
Negative_regulation (inhibition) of GABAergic associated with gabaergic and electroacupuncture
9) Confidence 0.05 Published 1991 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2051841 Disease Relevance 0 Pain Relevance 0.70
GABAergic activity is known to play a role in normal CNS development [86], and loss of GABAergic receptor subunits have functional consequences for cochlear processing [26].
Negative_regulation (loss) of GABAergic receptor in cochlear associated with gabaergic and central nervous system
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0 Pain Relevance 0.36
To test whether spontaneous GABAergic inhibition received by CA1 pyramidal cells during ongoing oscillations showed similar differences between NOD and Balbc mice as inhibition received by CA3 pyramidal cells, we recorded IPSCs in CA1 pyramidal neurons.
Spec (whether) Negative_regulation (inhibition) of GABAergic in pyramidal neurons associated with pyramidal cell and gabaergic
11) Confidence 0.03 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.18 Pain Relevance 0.39
Therefore it is likely that genetic variation influencing GABAergic inhibition could impact on neuronal network dynamics and cognition.
Negative_regulation (inhibition) of GABAergic in neuronal associated with cognitive disorder and gabaergic
12) Confidence 0.03 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.55 Pain Relevance 0.27
In contrast, the numbers of cholinergic, GABAergic, and somatostatin-containing interneurons in the ischemic striatum were not different from those in the contralateral hemisphere at 3 and 14 days.
Negative_regulation (numbers) of GABAergic in striatum associated with gabaergic and somatostatin
13) Confidence 0.03 Published 2003 Journal Brain Pathol. Section Abstract Doc Link 14655751 Disease Relevance 0.23 Pain Relevance 0.53
However, in CeA neurons of HET mice, the previously characterized ethanol-induced increase of GABAA-IPSPs was abolished.
Negative_regulation (abolished) of neurons in neurons associated with amygdala
14) Confidence 0.02 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.15 Pain Relevance 0.38
In addition, in CeA neurons from HET mice, the CRF-induced augmentation of IPSPs was also significantly decreased compared to those from WT mice.
Negative_regulation (decreased) of neurons in neurons associated with amygdala
15) Confidence 0.02 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.14 Pain Relevance 0.37
CRF superfusion also significantly augmented IPSPs (by 38%) and decreased PPF (by 23%) in WT CeA neurons, and still elicited a significant but smaller (by 13%) increase of IPSP amplitude, but no effect on PPF, in HET mice.
Negative_regulation (decreased) of neurons in neurons associated with amygdala
16) Confidence 0.02 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.33
PrP expression was observed to significantly decrease in siRNA-transfected neurons (Fig. 3 D).
Negative_regulation (decrease) of neurons in neurons
17) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.07 Pain Relevance 0.04
The EA-induced inhibition of GABAergic activity in the thalamus and pons-medulla was disinhibited when diazepam was pre-administered to rats treated with a single EA and reduced the EAA.
Negative_regulation (inhibition) of GABAergic in medulla associated with medulla, gabaergic, thalamus, electroacupuncture and analgesia
18) Confidence 0.02 Published 1989 Journal Neurosci. Res. Section Abstract Doc Link 2812569 Disease Relevance 0 Pain Relevance 1.10
As seen in this photomicrograph, many VTM neurons were immunoreactive for histamine, but a significant number of non-HA neurons were also found within the VTM.
Negative_regulation (number) of neurons in neurons
19) Confidence 0.01 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0 Pain Relevance 0
Deficient GABAergic Presynaptic Terminals in the ML of CHL1?
Negative_regulation (Deficient) of GABAergic associated with gabaergic
20) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0.08 Pain Relevance 0.13

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