INT11796

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Context Info
Confidence 0.31
First Reported 1981
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 52
Total Number 57
Disease Relevance 11.70
Pain Relevance 29.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Helt) nucleus (Helt) DNA binding (Helt)
Anatomy Link Frequency
neurons 26
ACC neurons 4
neuronal 4
ACC 2
nucleus 2
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 1236 100.00 Very High Very High Very High
Pyramidal cell 349 100.00 Very High Very High Very High
amygdala 226 100.00 Very High Very High Very High
GABAergic 199 100.00 Very High Very High Very High
orphanin 22 100.00 Very High Very High Very High
antiepileptic Drug 74 99.98 Very High Very High Very High
Spinal cord 26 99.84 Very High Very High Very High
Cannabinoid 10 99.82 Very High Very High Very High
Glutamate 258 99.76 Very High Very High Very High
Migraine 8 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 12 99.72 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.72 Very High Very High Very High
Sleep Disorders 162 99.68 Very High Very High Very High
Neuropathic Pain 130 99.22 Very High Very High Very High
Pain 73 99.16 Very High Very High Very High
Injury 28 98.60 Very High Very High Very High
Nociception 11 98.56 Very High Very High Very High
Toxicity 28 98.48 Very High Very High Very High
Anxiety Disorder 57 97.88 Very High Very High Very High
Targeted Disruption 257 97.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of 5-HT to increase GABAergic synaptic activity in the presence of 5-HT3 receptor blockade was mimicked by the selective 5-HT2 agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and blocked by the selective 5-HT2 antagonist ketanserin.
Positive_regulation (increase) of GABAergic associated with antagonist, gabaergic and agonist
1) Confidence 0.31 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580630 Disease Relevance 0 Pain Relevance 0.64
Previous studies have attributed this effect to the activation of HT-5(3) receptors located on GABAergic interneurons.
Positive_regulation (activation) of GABAergic in interneurons associated with gabaergic
2) Confidence 0.31 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9580630 Disease Relevance 0 Pain Relevance 0.50
But in Th the multiple EA or long-term diazepam-induced increase in GABAergic activity was significantly potentiated with the co-treatment of multiple EA and long-term diazepam for 15 consecutive days.
Positive_regulation (increase) of GABAergic associated with gabaergic, thalamus and electroacupuncture
3) Confidence 0.15 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 1598023 Disease Relevance 0 Pain Relevance 1.88
Single electroacupuncture (EA) exposure (10 Hz, 1 volt, 15 min) to long-term (15 consecutive days) diazepam (5 mg/kg/day, i.p.) treated adult male albino rats (120-140 g) potentiated the long-term diazepam-induced increase of GABAergic activity in thalamus (Th) but the long-term diazepam-induced inhibition of GABAergic activity in cerebral cortex (CC) and spinal cord (SC) was disinhibited under similar condition of treatment.
Positive_regulation (increase) of GABAergic in thalamus associated with gabaergic, thalamus, cerebral cortex, electroacupuncture and spinal cord
4) Confidence 0.15 Published 1992 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 1598023 Disease Relevance 0 Pain Relevance 1.11
Tetrodotoxin (TTX), which eliminates action-potential-dependent presynaptic effects, did not alter frequency, suggesting DHT may have increased PSC frequency by increasing connectivity between GABAergic and GnRH neurons.
Positive_regulation (increasing) of GABAergic in neurons associated with tetrodotoxin, gabaergic and primary sclerosing cholangitis
5) Confidence 0.09 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15342358 Disease Relevance 0.54 Pain Relevance 0.58
Using both the glutamic acid decarboxylase (GAD)(67)-green fluorescence protein (GFP) knock-in mouse and the tooth pulp stimulation model, we performed double-immunofluorescent histochemistry to determine the characteristics of GABAergic neuron activation in the spinal trigeminal nucleus.
Spec (determine) Positive_regulation (activation) of GABAergic in spinal trigeminal nucleus associated with targeted disruption, generalized anxiety disorder and gabaergic
6) Confidence 0.06 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20332333 Disease Relevance 0.28 Pain Relevance 0.20
Single-dose diazepam (5 mg/kg i.p.) which increases central GABAergic activity alone normalizes the 6 multiple electroacupuncture (EA) (10 Hz, 1 volt, 10 min/day)-induced inhibition of GABAergic activity in Th and PM and thus reduces the EAA of adult male albino rats (120 +/- 10 g).
Positive_regulation (increases) of GABAergic associated with gabaergic and electroacupuncture
7) Confidence 0.06 Published 1991 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2051841 Disease Relevance 0 Pain Relevance 0.56
The number of Fos-positive GABAergic neuronal profiles was significantly increased 2 hrs after tooth pulp stimulation.
Positive_regulation (increased) of GABAergic in neuronal associated with gabaergic
8) Confidence 0.05 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20332333 Disease Relevance 0.26 Pain Relevance 0.21
These mechanisms could explain the decreased BDZ binding after the repetitive administration of antiepileptic drugs enhancing the GABAergic system.
Positive_regulation (enhancing) of GABAergic associated with gabaergic and antiepileptic drug
9) Confidence 0.05 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.18 Pain Relevance 0.73
In CeA neurons of WT mice, ethanol superfusion significantly augmented (by 39%) GABAA-IPSPs and decreased PPF (by 25%), suggesting increased presynaptic GABA release.
Positive_regulation (augmented) of neurons in neurons associated with gaba and amygdala
10) Confidence 0.04 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.52
However, it is likely that the accumulation of PrPSc aggregates on neurons and glial cells (Rezaie and Lantos, 2001) results in enhanced glutamate levels in the diseased brain as caused by cell damage.
Positive_regulation (accumulation) of neurons in neurons associated with glutamate
11) Confidence 0.04 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.81 Pain Relevance 0.10
The ethanol- and CRF-induced increase in GABAergic transmission is mediated by CRF1 receptor activation, but the intracellular signaling mechanisms involved in this alteration in GABA transmission are still unknown.
Positive_regulation (increase) of GABAergic associated with gaba and gabaergic
12) Confidence 0.03 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.21 Pain Relevance 0.55
Ethanol enhancement of GABAergic transmission is absent in CeA neurons of HET mice
Positive_regulation (absent) of neurons in neurons associated with gabaergic and amygdala
13) Confidence 0.03 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.53
Fig S5 shows synapsin I (presynaptic protein) and NR1 (postsynaptic protein) expression patterns as visualized in WT and PrP-null mature primary hippocampal cultured neurons.
Positive_regulation (cultured) of neurons in neurons
14) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
The notion of enhanced NMDAR activity in PrP-null mouse neurons is consistent with the enhanced NMDA toxicity observed in our in vitro and in vivo studies and indicates that PrPC provides a degree of neuroprotection from glutamate toxicity.
Positive_regulation (enhanced) of neurons in neurons associated with toxicity and glutamate
15) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.27 Pain Relevance 0.09
We also applied longer NMDA puffs of 500-ms duration that resulted in a drastic slowing of decay kinetics in both cultures, which was nonetheless still significantly augmented in the null mouse neurons (unpublished data).
Positive_regulation (augmented) of neurons in neurons
16) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.09 Pain Relevance 0.06
This suggests the possibility of a functional upregulation of NR2D-containing receptors in PrP-null mouse neurons.
Positive_regulation (upregulation) of neurons in neurons
17) Confidence 0.03 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
Particularly, GRP receptor was co-localized with GAD67, a marker for GABA in some neurons, suggesting GRP receptor is expressed in a subpopulation of GABAergic interneurons.
Positive_regulation (subpopulation) of GABAergic in neurons associated with gaba and gabaergic
18) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.71
Activation of GRP receptors enhances spontaneous GABAergic, but not glutamatergic transmission
Neg (not) Positive_regulation (enhances) of GABAergic associated with gabaergic
19) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.66
On the other hand, some AEDs, e.g. topiramate, have efficacy for nonpsychiatric disorders including migraine, possibly by enhancing GABAergic and reducing glutamatergic neurotransmission.
Spec (possibly) Positive_regulation (enhancing) of GABAergic associated with gabaergic, migraine and antiepileptic drug
20) Confidence 0.02 Published 2008 Journal CNS Drugs Section Abstract Doc Link 18072813 Disease Relevance 1.39 Pain Relevance 1.40

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