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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.44
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2ry2) mitochondrion (P2ry2) plasma membrane (P2ry2)
lysosome (P2ry2) signal transducer activity (P2ry2)
P2ry2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 99.90 Very High Very High Very High
agonist 14 98.96 Very High Very High Very High
Pain 4 97.44 Very High Very High Very High
Action potential 10 96.84 Very High Very High Very High
adenocard 27 95.00 High High
Inflammatory response 6 88.80 High High
Adelta 2 82.64 Quite High
qutenza 8 79.52 Quite High
Glutamate 20 73.44 Quite High
Central nervous system 6 72.96 Quite High
Disease Link Frequency Relevance Heat
Pain 4 97.44 Very High Very High Very High
Nociception 6 96.56 Very High Very High Very High
INFLAMMATION 22 88.40 High High
Hypoxia 2 25.08 Quite Low
Injury 4 22.08 Low Low
Stress 1 21.40 Low Low
Neurodegenerative Disease 1 16.16 Low Low
Epilepsy 29 6.00 Low Low
Convulsion 11 5.00 Very Low Very Low Very Low
Depression 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect was specific for P2Y2/P2Y4 receptors, as the P2Y6 ligand UDP never activated C fibers.
P2Y2 Binding (specific) of
1) Confidence 0.36 Published 2004 Journal Pain Section Abstract Doc Link 15082124 Disease Relevance 0.16 Pain Relevance 0.51
This receptor was originally classified as a member of the P2Y receptor family on the basis of sequence identity and its ability to bind the nucleotides ATP and ADP [25].
P2Y Binding (bind) of
2) Confidence 0.31 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.09 Pain Relevance 0.15
In addition, a key role for P2X7 receptors is established as well as possibly contributory roles for P2X2, P2X4, P2X5, P2Y2, P2Y4 and P2Y14 based on agonist preferences [40].
P2Y2 Binding (roles) of associated with agonist
3) Confidence 0.11 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583203 Disease Relevance 0 Pain Relevance 0.18
ATP-induced relaxation was antagonised by suramin, non-selective P2 receptor antagonist, by desensitisation of P2Y receptors with ADPbetaS, and increased by desensitisation of P2X receptors with alpha,beta-MeATP. alpha,beta-MeATP produced biphasic responses: relaxation, reduced by P2X- or P2Y desensitisation, and contraction, almost abolished by P2X desensitisation and potentiated by P2Y desensitisation. 2-MeSATP induced relaxation, which was antagonised by P2Y desensitisation and increased by P2X desensitisation.
P2Y Binding (desensitisation) of associated with antagonist
4) Confidence 0.04 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15878718 Disease Relevance 0 Pain Relevance 0.21
Metabotropic P2Y receptors, some of which bind pyrimidines as well as purines, have received little attention.
P2Y Binding (bind) of
5) Confidence 0.01 Published 2004 Journal Pain Section Abstract Doc Link 15082124 Disease Relevance 0.19 Pain Relevance 0.27

General Comments

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